Towards understanding leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator–activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors?

Autor: Malgorzata Kotula-Balak, Jan Karol Wolski, Waclaw Tworzydlo, Ewelina Gorowska-Wojtowicz, Agnieszka Milon, I. Krakowska, Barbara Bilińska, Bartosz J. Płachno, P. Pawlicki, Anna Hejmej

Publikováno v: Protoplasma

Leydig cell tumors (LCT) are the most common type of testicular stromal tumor. Herein, we investigate the G protein-coupled estrogen receptor (GPER) and peroxisome proliferator–activated receptor (PPAR) implication in regulation of lipid homeostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da416860fdf28a8c0865adee888c3493
http://europepmc.org/articles/PMC7329793

Interstitial Leydig cell tumorigenesis : leptin and adiponectin signaling in relation to aromatase expression in the human testis

Autor: Malgorzata Kotula-Balak, Izabella Krakowska, Ewelina Gorowska-Wojtowicz, Agnieszka Rak, Malgorzata Brzoskwinia, Bartosz J. Płachno, Barbara Bilińska, Waclaw Tworzydlo, Michal Duliban, Jan Karol Wolski

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences, Vol 21, Iss 3649, p 3649 (2020)

Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1e1fe60a69ee21225311c0bd1ac07e
https://ruj.uj.edu.pl/xmlui/handle/item/156851

Leydig cell tumorigenesis - implication of G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and xenoestrogen exposure : in vivo and in vitro appraisal

Autor: Agnieszka Milon, Barbara Bilińska, Ewelina Gorowska-Wojtowicz, Malgorzata Kotula-Balak, W. Placha, Michal Duliban, P. Dutka, M. Kudrycka, Jan Karol Wolski, Marta Zarzycka, P. Pawlicki, Anna Ptak

The etiology and molecular characteristics of Leydig cell tumor (LCT) are scarcely known. From the research data stems that estrogen can be implicated in LCT induction and development, however it is not investigated in detail. Considering the above,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbf04bd78c9ca9604daa630937a87dd
https://ruj.uj.edu.pl/xmlui/handle/item/129170

The risk of neoplasm associated with dysgenetic testes in prepubertal and pubertal/adult patients

Autor: Krzysztof Kula, Jerzy Niedzielski, Jan Karol Wolski, Katarzyna Marchlewska, Elżbieta Oszukowska, Jolanta Słowikowska-Hilczer, Maciej Hilczer, Malgorzata Baka-Ostrowska, Bogdan Kałużewski, Maria Szarras-Czapnik, Eliza Filipiak, Renata Walczak-Jędrzejowska, Lucjusz Jakubowski

Publikováno v: Folia Histochemica et Cytobiologica. 53:218-226

Introduction. In patients with Y-chromosome in the karyotype, partial gonadal dysgenesis and disorders of male reproductive sex organs development are usually resected in childhood because of the high risk of germ cell tumours (GCT). In patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17711ffae46903e3f74b90ca5186227c
https://doi.org/10.5603/fhc.a2015.0021

Assessment of quality of life in patients surgically treated for penile cancer: Impact of aggressiveness in surgery

Autor: Tomasz Demkow, Roman Sosnowski, Tomasz Kalinowski, Jan Karol Wolski, Urszula Ziętalewicz, Marta Kulpa, Mariola Kosowicz

Publikováno v: European journal of oncology nursing : the official journal of European Oncology Nursing Society. 31

Purpose Health-related quality of life (HRQoL) evaluations are being increasingly used for clinical assessment of cancer treatment outcomes. For a patient, not only is life expectancy important, but also a general sense of sustained global health. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225e3321516a26a5d767bb72c3ddef86
https://pubmed.ncbi.nlm.nih.gov/29173821