Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jan Kahmann"'
Autor:
Jan Kahmann
Am 5. April 2010 wird das deutsche Containerschiff Taipan vor der Küste Somalias von Piraten gekapert. Nach drei Stunden, in denen sich die Mannschaft unter Deck verschanzt, greift die niederländische Marine ein und befreit die Besatzung. Die zehn
Autor:
Paul Hoff Backe, Tuva H. Hereng, Bjørn Steen Skålhegg, K.R. Rosendal, Magnar Bjørås, Jan Kahmann, Christoph Scheich
Publikováno v:
Journal of Structural Biology. 178:300-310
Protein kinase A (PKA) exists as several tissue-specific isoforms that through phosphorylation of serine and threonine residues of substrate proteins act as key regulators of a number of cellular processes. We here demonstrate that the human sperm-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17e717aad4fe096a2aae712f396f8f5
https://doi.org/10.1016/j.jsb.2012.03.013
https://doi.org/10.1016/j.jsb.2012.03.013
Publikováno v:
Drug Discovery Today: Technologies. 5:e15-e22
The routine application of high-throughput screening (HTS) of compound files has shifted the bottleneck in target-based drug discovery from hit identification to hit qualification because not all hit molecules have the potential to become leads and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fc62c7a69b16466f6106f233908336
https://doi.org/10.1016/j.ddtec.2008.12.005
https://doi.org/10.1016/j.ddtec.2008.12.005
Autor:
Michael F. Mesleh, Joseph Shotwell, Terence Moy, Jan Kahmann, Michael W. Wood, Andrea T. Hadfield, Ole A. Andersen, Roland E. Dolle, M. Dominic Ryan, John M. Barker, Brunella Felicetti, Kien T. Nguyen, Christoph Scheich, Jason B. Cross, Qingyi Yang, Jing Zhang, Lippa Blaise S, Robert K. Y. Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(4)
Inhibitors of the ATPase function of bacterial DNA gyrase, located in the GyrB subunit and its related ParE subunit in topoisomerase IV, have demonstrated antibacterial activity. In this study we describe an NMR fragment-based screening effort target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306576714b0d8695558ef8a348dc8c12
https://pubmed.ncbi.nlm.nih.gov/26786695
https://pubmed.ncbi.nlm.nih.gov/26786695
Autor:
Dirk Winkler, Jan Kahmann, Sabine Schaertl, Joachim Kraemer, Oliver Keminer, Osamu Ichihara, Dirk Ullmann, Ina Sternberger, Christoph Scheich, Thomas Hesterkamp, Mark Whittaker, Joern Jungmann
Publikováno v:
Combinatorial chemistryhigh throughput screening. 12(7)
Inhibitors of MAPKAP kinase 2 (MK2) are expected to attenuate the p38alpha signal transduction pathway in macrophages in a similar way to p38alpha inhibitors and to have a lower propensity for toxic side effects that have slowed the clinical developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5951e8cebcfa2f099624c807c533438
https://pubmed.ncbi.nlm.nih.gov/19531016
https://pubmed.ncbi.nlm.nih.gov/19531016