Pharmacological strategies for detoxification

Autor: Fergus D. Law, Jan K. Melichar, Alison Diaper

Publikováno v: British Journal of Clinical Pharmacology. 77:302-314

Detoxification refers to the safe discontinuation from a substance of dependence and is distinct from relapse prevention. Detoxification usually takes between a few days and a few weeks to complete, depending on the substance being misused, the sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80c52881455a4df0edb9a9b1746aaa94
https://doi.org/10.1111/bcp.12245

Taste and weight: is there a link?

Autor: Jan K. Melichar, Lucy F. Donaldson, Sue Baic, Lisa Bennett

Publikováno v: The American Journal of Clinical Nutrition. 90:800S-803S

Investigations of the relations between taste perception and obesity have concentrated largely on sweet and bitter tastes, with little work on the "savory" tastes-salt and glutamate-and very little work on sour taste. This article briefly reviews cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36254aa848663da3f42ccf106a7423d5
https://doi.org/10.3945/ajcn.2009.27462q

Ranking the harm of non-medically used prescription opioids in the UK

Autor: Owen Bowden-Jones, Wim van den Brink, Jan K. Melichar, Annette Dale-Perera, John Ramsey, Graeme Henderson, Lawrence D. Phillips, Polly Taylor, Richard Hammersley, David J. Nutt, Jimmy D. Bell, Jan van Amsterdam

Publikováno v: van Amsterdam, J, Phillips, L, Henderson, G, Bell, J, Bowden-Jones, O, Hammersley, R, Ramsey, J, Taylor, P, Dale-Perera, A, Melichar, J, van den Brink, W & Nutt, D 2015, ' Ranking the harm of non-medically used prescription opioids in the UK ', Regulatory Toxicology and Pharmacology, vol. 73, no. 3, pp. 999-7004 . https://doi.org/10.1016/j.yrtph.2015.09.014
Regulatory toxicology and pharmacology, 73(3), 999-1004. Academic Press Inc.

A panel of nine experts applied multi-criteria decision analysis (MCDA) to determine the relative overall harm to users and harms to others of street heroin (injected and smoked) and eleven non-medically used prescription opioids. The experts assesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29235f07fffe774ee1ee0c59200a61c2
https://research-information.bris.ac.uk/en/publications/b7396f2d-a074-435b-97c6-ff85067818cf

Using [11C]Diprenorphine to Image Opioid Receptor Occupancy by Methadone in Opioid Addiction: Clinical and Preclinical Studies

Autor: L.G. Taylor, Andrea Malizia, Jan K. Melichar, Anne Lingford-Hughes, J. S. Myles, Mark Daglish, Tim M. Williams, Susan P. Hume, Rabia Ahmad, David J. Brooks, David J. Nutt

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 312:309-315

Substitute methadone prescribing is one of the main modes of treatment for opioid dependence with established evidence for improved health and social outcomes. However, the pharmacology underpinning the effects of methadone is little studied despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0c82914d5586b4eccb29df722b53fe
https://doi.org/10.1124/jpet.104.072686

Venlafaxine occupation at the noradrenaline reuptake site: in-vivo determination in healthy volunteers

Autor: A. Haida, Jan K. Melichar, David J. Nutt, Alan H. Reynolds, Andrea Malizia, Christopher G. Rhodes

Publikováno v: Journal of Psychopharmacology. 15:9-12

Venlafaxine, a serotonin and noradrenaline reuptake inhibitor, is an effective antidepressant at doses of 75 mg p.o. daily and above. Preclinical and healthy volunteer studies have demonstrated that venlafaxine is more potent at the serotonin than at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9075b0417b25911077edd39c1d5511f1
https://doi.org/10.1177/026988110101500102