Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jan K. Kitajewski"'
Autor:
Bhairavi Swaminathan, Seock-Won Youn, L. A. Naiche, Jing Du, Stephanie R. Villa, Jordan B. Metz, Huijuan Feng, Chaolin Zhang, Raphael Kopan, Peter A. Sims, Jan K. Kitajewski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors. Not
Externí odkaz:
https://doaj.org/article/2acddc161e984fb29a05d7f50cd5c46f
Autor:
Vijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska-Wodnicka, Arkadiusz Z. Dudek, Lena Claesson-Welsh, Jan K. Kitajewski, Kishore K. Wary, Asrar B. Malik, Dolly Mehta
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3472-3487.e4 (2019)
Summary: The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2
Externí odkaz:
https://doaj.org/article/ca069aac595949f996eaf14ed636dcbc
Publikováno v:
Biology Open, Vol 8, Iss 4 (2019)
Proper development and function of the mammalian placenta requires interactions between embryo-derived trophoblasts and uterine endothelial cells to form mosaic vessels that facilitate blood flow to a developing conceptus. Notch signaling utilizes a
Externí odkaz:
https://doaj.org/article/bf58ccb9b2dd417cbfa352dadce81bd2
Autor:
Johanna Finn, Kilian Sottoriva, Kostandin V. Pajcini, Jan K. Kitajewski, Chang Chen, Wei Zhang, Asrar B. Malik, Yuru Liu
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2942-2954.e5 (2019)
Summary: Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, in
Externí odkaz:
https://doaj.org/article/01f351cd90214d9b9d6b15c8d7353b49
Autor:
Nicole M. Marchetto, Salma Begum, Tracy Wu, Valerie O’Besso, Christina C. Yarborough, Nuriban Valero-Pacheco, Aimee M. Beaulieu, Jan K. Kitajewski, Carrie J. Shawber, Nataki C. Douglas
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6477 (2020)
Maternal spiral arteries and newly formed decidual capillaries support embryonic development prior to placentation. Previous studies demonstrated that Notch signaling is active in endothelial cells of both decidual capillaries and spiral arteries, ho
Externí odkaz:
https://doaj.org/article/b34b5e504f0647aea7020f2ce6826398
Autor:
Timothy Sargis, Seock-Won Youn, Krishna Thakkar, L. A. Naiche, Na Yoon Paik, Kostandin V. Pajcini, Jan K. Kitajewski
Publikováno v:
Angiogenesis. 26:249-263
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notc
Autor:
Darrell J. Yamashiro, Jessica J. Kandel, Jan K. Kitajewski, Carrie J. Shawber, Angela Kadenhe-Chiweshe, Na Wei, Lynn Ann Forrester, John Andrews, Emily Sbiroli, Thaned Kangsamaksin, Alejandro Garcia, Sonia L. Hernandez, Debarshi Banerjee
Supplementary Figures S1-S12 and Legends. Supplementary Figure S1. Combined Inhibition of Notch and VEGF disrupts interaction of pericytes with endothelial cells in primary tumors Supplementary Figure S2. Inhibition of Notch increases liver metastase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48c0ffb8d1914832eaa1a5ef52ba056
https://doi.org/10.1158/0008-5472.22406447
https://doi.org/10.1158/0008-5472.22406447
Autor:
Darrell J. Yamashiro, Jessica J. Kandel, Jan K. Kitajewski, Carrie J. Shawber, Angela Kadenhe-Chiweshe, Na Wei, Lynn Ann Forrester, John Andrews, Emily Sbiroli, Thaned Kangsamaksin, Alejandro Garcia, Sonia L. Hernandez, Debarshi Banerjee
The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging therapies. Here, we show that inhibition of Notch, using a soluble receptor Notch1 decoy, unexpect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4c1bfcb541693c573721048a834017
https://doi.org/10.1158/0008-5472.c.6507077
https://doi.org/10.1158/0008-5472.c.6507077
Autor:
Darrell J. Yamashiro, Jessica J. Kandel, Jan K. Kitajewski, Carrie J. Shawber, Angela Kadenhe-Chiweshe, Na Wei, Lynn Ann Forrester, John Andrews, Emily Sbiroli, Thaned Kangsamaksin, Alejandro Garcia, Sonia L. Hernandez, Debarshi Banerjee
Supplementary Table 1. Antibodies utilized in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6386ade79ddeb1f7b4b4d9ea99f078
https://doi.org/10.1158/0008-5472.22406441
https://doi.org/10.1158/0008-5472.22406441
Autor:
Darrell J. Yamashiro, Jessica J. Kandel, Jan K. Kitajewski, Carrie J. Shawber, Angela Kadenhe-Chiweshe, Na Wei, Lynn Ann Forrester, John Andrews, Emily Sbiroli, Thaned Kangsamaksin, Alejandro Garcia, Sonia L. Hernandez, Debarshi Banerjee
Supplementary Methods. Reverse transcription and quantitative PCR. BrdU Proliferation Assay. In vivo BrdU assay. Migration and Invasion Assays. Adenovirus production and Injection. siRNA transfection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78412beaec8157edc9a03cbd50af5bbc
https://doi.org/10.1158/0008-5472.22406444.v1
https://doi.org/10.1158/0008-5472.22406444.v1