Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Jan Jong Hung"'
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2255-2276 (2024)
Cancer represents a profound challenge to healthcare systems and individuals worldwide. The development of multiple drug resistance is a major problem in cancer therapy and can result in progression of the disease. In our previous studies, we develop
Externí odkaz:
https://doaj.org/article/028ca98568eb49199a3866f73eabb282
Autor:
Thi Thanh Truc Tran, Jan-Jong Hung
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Lung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous studies have indicated that PTEN, as a tumor suppressor, inhibits cancer formation. In this study
Externí odkaz:
https://doaj.org/article/a5f3ca7b726d42ca8b631941bdd8f0dc
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Tumor heterogeneity is the major factor for inducing drug resistance. p53 is the major defender to maintain genomic stability, which is a high proportion mutated in most of the cancer types. In this study, we established in vivo animal model
Externí odkaz:
https://doaj.org/article/d7ed534d60404f2d8d06f4ca0187b6d8
Autor:
Yung-Ching Chen, Ming-Jer Young, Hui-Ping Chang, Chia-Yu Liu, Chia-Chi Lee, Yau-Lin Tseng, Yi-Ching Wang, Wen-Chang Chang, Jan-Jong Hung
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Previous studies indicate that estrogen positively regulates lung cancer progression. Understanding the reasons will be beneficial for treating women with lung cancer in the future. In this study, we found that tumor formation was more signi
Externí odkaz:
https://doaj.org/article/a0ab8ee31dec4faa8f3e2a5926d35058
Autor:
Ming-Jer Young, Yung-Ching Chen, Shao-An Wang, Hui-Ping Chang, Wen-Bin Yang, Chia-Chi Lee, Chia-Yu Liu, Yau-Lin Tseng, Yi-Ching Wang, H. Sunny Sun, Wen-Chang Chang, Jan-Jong Hung
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-22 (2022)
Abstract Background Sp1, an important transcription factor, is involved in the progression of various cancers. Our previous studies have indicated that Sp1 levels are increased in the early stage of lung cancer progression but decrease during the lat
Externí odkaz:
https://doaj.org/article/d228509c4c3d440e80245ee03d7ed8bd
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Abstract Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such as cancer. Two types of enzymes,
Externí odkaz:
https://doaj.org/article/0603c3805d0b4601a7980a5b0baa24cb
Autor:
Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu, Jan-Jong Hung
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promote
Externí odkaz:
https://doaj.org/article/26cc8ac4dab1440cb49c6ac5e82792df
Autor:
Kwang-Yu Chang, Tsung-I. Hsu, Che-Chia Hsu, Shan-Yin Tsai, Jr-Jiun Liu, Shao-Wen Chou, Ming-Sheng Liu, Jing-Ping Liou, Chiung-Yuan Ko, Kai-Yun Chen, Jan-Jong Hung, Wen-Chang Chang, Cheng-Keng Chuang, Tzu-Jen Kao, Jian-Ying Chuang
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 655-664 (2017)
Acquisition of temozolomide (TMZ) resistance is a major factor leading to the failure of glioblastoma (GBM) treatment. The exact mechanism by which GBM evades TMZ toxicity is not always related to the expression of the DNA repair enzyme O6-methylguan
Externí odkaz:
https://doaj.org/article/2cfb7d3e1f924bd3bbb0af1a34f9768a
Autor:
Chia-Yang Hung, Yi-Chang Wang, Jian-Ying Chuang, Ming-Jer Young, Hungjiun Liaw, Wen-Chang Chang, Jan-Jong Hung
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Our recent studies have indicated that specificity protein-1 (Sp1) accumulates substantially in the early stage of lung cancer but is partially decreased in the late stages, which is an important factor in the progression of the cancer. In t
Externí odkaz:
https://doaj.org/article/acc719a6d1194327ac7a083d87076379
Autor:
Wen-Pin Su, Yen-Chih Ho, Cheng-Kuei Wu, Sen-Huei Hsu, Jia-Lin Shiu, Jheng-Cheng Huang, Song-Bin Chang, Wen-Tai Chiu, Jan-Jong Hung, Tsung-Lin Liu, Wei-Sheng Wu, Pei-Yu Wu, Wu-Chou Su, Jang-Yang Chang, Hungjiun Liaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regul
Externí odkaz:
https://doaj.org/article/c4f9f089fbaf4a23a3f257a7acb65763