Výsledky vyhledávání - "Jan Joep H.H.M. De Pont"

The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase

Autor: Jan B. Koenderink, Gijs Schaftenaar, Jan Joep H.H.M. De Pont, Herman G.P. Swarts, Anna Karawajczyk, Peter H.G.M. Willems

Publikováno v: Pflügers Archiv : European Journal of Physiology, 457, 623-34
Pflügers Archiv : European Journal of Physiology, 457, 3, pp. 623-34

Contains fulltext : 81222.pdf (Publisher’s version ) (Closed access) Based on studies with chimeras between (non-)gastric H,K-ATPase and Na,K-ATPase, a model for the ouabain binding site has recently been presented (Qiu et al. J.Biol.Chem. 280 (200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5b86b9eea4347a6000ff9a06a720f2
https://doi.org/10.1007/s00424-008-0467-8

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Conversion of the low affinity ouabain-binding site of non-gastric H,K-ATPase into a high affinity binding site by substitution of only five amino acids

Autor: Li Yan Qiu, Herman G.P. Swarts, Jan B. Koenderink, Jan Joep H.H.M. De Pont, Elisa C.M. Tonk, Peter H.G.M. Willems

Publikováno v: Journal of Biological Chemistry, 281, 13533-9
Journal of Biological Chemistry, 281, 19, pp. 13533-9

Contains fulltext : 49286.pdf (Publisher’s version ) (Open Access) P-type ATPases of the IIC subfamily exhibit large differences in sensitivity toward ouabain. This allows a strategy in which ouabain-insensitive members of this subfamily are used a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2b32684b2b24da082339bada3ef587
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/49286

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Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids

Autor: Gijs Schaftenaar, Herman G.P. Swarts, Peter H.G.M. Willems, Jan B. Koenderink, Elmar Krieger, Jan Joep H.H.M. De Pont, Li Yan Qiu

Publikováno v: Journal of Biological Chemistry, 280, 32349-32355
Journal of Biological Chemistry, 280, 37, pp. 32349-32355
Journal of Biological Chemistry, 280, 37, pp. 32349-55
Journal of Biological Chemistry, 280, 32349-55

Contains fulltext : 32914.pdf (Publisher’s version ) (Open Access) Contains fulltext : 189403.pdf (Publisher’s version ) (Open Access) Although cardiac glycosides have been used as drugs for more than 2 centuries and their primary target, the sod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57b7cc24ac6890670c288aba9a3f8fb
https://doi.org/10.1074/jbc.m505168200

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The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase

Autor: Herman G.P. Swarts, Jan B. Koenderink, Jan Joep H.H.M. De Pont, Peter H.G.M. Willems

Publikováno v: Journal of Biological Chemistry, 280, 33115-22
Journal of Biological Chemistry, 280, 39, pp. 33115-22

Contains fulltext : 48560.pdf (Publisher’s version ) (Open Access) We used the baculovirus/Sf9 expression system to gain new information on the mechanistic properties of the rat non-gastric H,K-ATPase, an enzyme that is implicated in potassium home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52505ac964c5106862de94a9f43b5d84
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/48560

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Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation

Autor: Giovanni Zifarelli, Ernst Bamberg, Jan B. Koenderink, Thomas Friedrich, Li Yan Qiu, Wolfgang Schwarz, Jan Joep H.H.M. De Pont

Publikováno v: Biochimica et Biophysica Acta. Biomembranes, 1669, 61-8
Biochimica et Biophysica Acta. Biomembranes, 1669, 1, pp. 61-8

Contains fulltext : 48917.pdf (Publisher’s version ) (Closed access) The Na,K-ATPase is an ion-translocating transmembrane protein that actively maintains the electrochemical gradients for Na+ and K+ across the plasma membrane. The functional prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6327766a4aae389609d70698a9d6cf
https://doi.org/10.1016/j.bbamem.2005.01.003

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The E1/E2-Preference of Gastric H,K-ATPase Mutants

Autor: Peter H.G.M. Willems, Jan B. Koenderink, Herman G.P. Swarts, Jan Joep H.H.M. De Pont

Publikováno v: Annals of the New York Academy of Sciences. 986:175-182

Gastric H,K-ATPase has, in the absence of ATP and added ions, a preference for the E(2) conformation. Mutations in the cation-binding pocket often result in a preference for the E(1)-conformation. This can be paralleled by the occurrence of K(+)-inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3c2df703db37bf8965c3fae99e30c3
https://doi.org/10.1111/j.1749-6632.2003.tb07157.x

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Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket

Autor: Eva Grabsch, Sven Geibel, Ernst Bamberg, Thomas Friedrich, Jan Joep H.H.M. De Pont, Jan B. Koenderink

Publikováno v: Journal of Biological Chemistry, 278, 51, pp. 51213-22
Journal of Biological Chemistry, 278, 51213-22

Contains fulltext : 142631.pdf (Publisher’s version ) (Open Access) Na,K-ATPase mediates net electrogenic transport by extruding three Na+ ions and importing two K+ ions across the plasma membrane during each reaction cycle. We mutated putative cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22678ff38897f0f6f880f72098174069
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/142631

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Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit

Autor: Lambert P. van den Heuvel, Jan Joep H.H.M. De Pont, Leo A. H. Monnens, Jan B. Koenderink, Iwan C. Meij, Nine V A M Knoers, Joke C. de Jong

Publikováno v: Annals of the New York Academy of Sciences, 986, pp. 437-43
Annals of the New York Academy of Sciences, 986, 437-43

Item does not contain fulltext Hereditary primary hypomagnesemia comprises a clinically and genetically heterogeneous group of disorders in which hypomagnesemia is due to either renal or intestinal Mg(2+) wasting. These disorders share the general sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c4a909760c6b8e5b7cf31616cae1a
https://doi.org/10.1111/j.1749-6632.2003.tb07226.x

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K+-independent Gastric H+,K+-ATPase Activity

Autor: Jan Joep H.H.M. De Pont, Peter H.G.M. Willems, H.P.H. Hermsen, Jan B. Koenderink, Herman G.P. Swarts

Publikováno v: Journal of Biological Chemistry. 276:36909-36916

Several mutations of residues Glu(795) and Glu(820) present in M5 and M6 of the catalytic subunit of gastric H(+),K(+)-ATPase have resulted in a K(+)-independent, SCH 28080-sensitive ATPase activity, caused by a high spontaneous dephosphorylation rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e76fcf5e302164713be8681e37406ba6
https://doi.org/10.1074/jbc.m103945200

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Chimeras of X+,K+-ATPases

Autor: Herman G.P. Swarts, Peter H.G.M. Willems, H. Christiaan Stronks, H.P.H. Hermsen, Jan B. Koenderink, Jan Joep H.H.M. De Pont

Publikováno v: Journal of Biological Chemistry. 276:11705-11711

In this study we reveal regions of Na(+),K(+)-ATPase and H(+),K(+)-ATPase that are involved in cation selectivity. A chimeric enzyme in which transmembrane hairpin M5-M6 of H(+),K(+)-ATPase was replaced by that of Na(+),K(+)-ATPase was phosphorylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc3e410241816be8f564b865983e6f0
https://doi.org/10.1074/jbc.m010804200

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