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pro vyhledávání: '"Jan Jasper Klein"'
Publikováno v:
Journal of Lipids, Vol 2011 (2011)
The lipid-signalling molecule ceramide is known to induce apoptosis in a variety of cell types. Inhibition of the lysosomal acid ceramidase can increase cellular ceramide levels and thus induce apoptosis. Indeed, inhibitors of acid ceramidase have be
Externí odkaz:
https://doaj.org/article/8a873fcb527a4dd1ab3370f5cf9fd93d
Autor:
Jan Jasper Klein, Stefan Hecht
Publikováno v:
Organic letters. 14(1)
The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the sca