Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jan J. Mataka"'
Autor:
Jan J. Mataka, Silvia L. Delker, Thomas L. Poulos, James M. Kraus, Kristin J. Labby, Richard B. Silverman, Huiying Li, Pavel Martásek, Haitao Ji, Linda J. Roman, Fengtian Xue
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:1333-1343
Inhibitors of neuronal nitric oxide synthase have been proposed as therapeutics for the treatment of different types of neurological disorders. On the basis of a cis-3,4-pyrrolidine scaffold, a series of trans-cyclopropyl- and methyl-containing nNOS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad9b2acca38c563e0b5f71e1ae053d0
https://doi.org/10.1016/j.bmc.2012.12.019
https://doi.org/10.1016/j.bmc.2012.12.019
Autor:
Fengtian Xue, Richard B. Silverman, Kristin J. Labby, Pavel Martásek, Thomas L. Poulos, Haitao Ji, Guoyao Xia, Huiying Li, Linda J. Roman, James M. Kraus, Silvia L. Delker, Jan J. Mataka
Publikováno v:
Journal of Medicinal Chemistry. 54:6399-6403
We report an efficient synthetic route to chiral pyrrolidine inhibitors of neuronal nitric oxide synthase (nNOS) and crystal structures of the inhibitors bound to nNOS and to endothelial NOS. The new route enables versatile structure activity relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3571ed8ff55e040aa553d1e4578a32
https://doi.org/10.1021/jm200411j
https://doi.org/10.1021/jm200411j
Publikováno v:
Journal of medicinal chemistry. 56(8)
The development of new therapeutics for the treatment of neurodegenerative pathophysiologies currently stands at a crossroads. This presents an opportunity to transition future drug discovery efforts to target disease modification, an area in which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672f0e797e86be9f5cc23da0f6e76981
https://pubmed.ncbi.nlm.nih.gov/23458846
https://pubmed.ncbi.nlm.nih.gov/23458846
Autor:
Huiying Li, Kristin J. Labby, Jan J. Mataka, Richard B. Silverman, James M. Kraus, Fengtian Xue, Thomas L. Poulos, Linda J. Roman, Pavel Martásek, Haitao Ji
Publikováno v:
Bioorganicmedicinal chemistry. 20(7)
Selective neuronal nitric oxide synthase (nNOS) inhibitors have therapeutic applications in the treatment of numerous neurodegenerative diseases. Here we report the synthesis and evaluation of a series of inhibitors designed to have increased cell me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2834b147c750a2e7aceea6b4ddbadff4
https://pubmed.ncbi.nlm.nih.gov/22370337
https://pubmed.ncbi.nlm.nih.gov/22370337
Autor:
Li H; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA., Xue F, Kraus JM 2nd, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Mar 01; Vol. 21 (5), pp. 1333-43. Date of Electronic Publication: 2012 Dec 22.
Autor:
Labby KJ; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA., Xue F, Kraus JM, Ji H, Mataka J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Apr 01; Vol. 20 (7), pp. 2435-43. Date of Electronic Publication: 2012 Feb 07.
Autor:
Xue F; Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, USA., Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2011 Sep 22; Vol. 54 (18), pp. 6399-403. Date of Electronic Publication: 2011 Aug 22.
Autor:
Crich D; Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061, USA. dcrich@uic.edu, Mataka J, Zakharov LN, Rheingold AL, Wink DJ
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2002 May 29; Vol. 124 (21), pp. 6028-36.