Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jan Inge Øvrebø"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The active site of the essential CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in the single CDK1 ortholog of all metazoans. We report serial CDK1 duplications
Externí odkaz:
https://doaj.org/article/da2c673b409f4e92a972deb0820ecc32
Autor:
Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud T. Iversen, Jan Sommerfelt-Pettersen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 806-817 (2017)
BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evalu
Externí odkaz:
https://doaj.org/article/984fb2741bd640468078af8a1510e84f
Autor:
Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud Titlestad Iversen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative me
Externí odkaz:
https://doaj.org/article/f268acc168ec49dc856cd974179968ac
Publikováno v:
Bioessays
Before a cell divides into two daughter cells, it typically doubles not only its DNA, but also its mass. Numerous studies in cells ranging from yeast to mammals have shown that cellular growth, stimulated by nutrients and/or growth factor signaling,
Autor:
Jan Inge Øvrebø, Mary-Rose Bradley-Gill, Norman Zielke, Minhee Kim, Marco Marchetti, Jonathan Bohlen, Megan Lewis, Monique van Straaten, Nam-Sung Moon, Bruce A. Edgar
E2F transcription factors are master regulators of the eukaryotic cell cycle. In Drosophila, the sole activating E2F, E2F1, is both required for and sufficient to promote G1 -> S progression. E2F1 activity is regulated both by binding to RB Family re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a0b7b3aafd64bfb3290a59d87d5bc2
http://hdl.handle.net/10138/353908
http://hdl.handle.net/10138/353908
Autor:
Jan Inge, Øvrebø, Mary-Rose, Bradley-Gill, Norman, Zielke, Minhee, Kim, Marco, Marchetti, Jonathan, Bohlen, Megan, Lewis, Monique, van Straaten, Nam-Sung, Moon, Bruce A, Edgar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Here, we explore a mechanism wherein the growth signaling-dependent translation of mRNA encoding a cell cycle regulatory factor limits rates of cell proliferation. An essential cell cycle transcription factor, E2F1, was found to be post-
Autor:
Yiqin Ma, Laura Buttitta, Huaqi Jiang, Jan Inge Øvrebø, Peng Zhang, Bruce A. Edgar, Derek W. Nickerson, Alexia J. Katzaroff
Publikováno v:
Proc Natl Acad Sci U S A
Using a gain-of-function screen in Drosophila, we identified the Kruppel-like factor Cabut (Cbt) as a positive regulator of cell cycle gene expression and cell proliferation. Enforced cbt expression is sufficient to induce an extra cell division in t
Autor:
Liv Beathe Gansmo, Johanna Huun, Stian Knappskog, Bård Mannsåker, Per Eystein Lønning, Gjertrud T. Iversen, Jan Inge Øvrebø
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-9 (2017)
BMC Cell Biology
BMC Cell Biology
Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism o
Autor:
Jan Inge Øvrebø, Bruce A. Edgar
Publikováno v:
Development. 145
Polyploid cells, which contain multiple copies of the typically diploid genome, are widespread in plants and animals. Polyploidization can be developmentally programmed or stress induced, and arises from either cell-cell fusion or a process known as
Autor:
Geir Lasse Taranger, Sigurd O. Stefansson, Tom Ole Nilsen, Ivar Rønnestad, Anna R. Angotzi, Jan Inge Øvrebø, Eva Andersson
Publikováno v:
General and comparative endocrinology. 235
In recent years rapidly growing research has led to identification of several fish leptin orthologs and numerous duplicated paralogs possibly arisen from the third and fourth round whole genome duplication (3R and 4R WGD) events. In this study we ide