Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Jan Hoeijmakers"'
1
Akademický článek
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.
Autor: Silvia Gravina, Martijn E T Dollé, Tao Wang, Harry van Steeg, Paul Hasty, Jan Hoeijmakers, Jan Vijg
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73496 (2013)
A gradual loss of the correct patterning of 5-methyl cytosine marks in gene promoter regions has been implicated in aging and age-related diseases, most notably cancer. While a number of studies have examined DNA methylation in aging, there is no con
Externí odkaz: https://doaj.org/article/6829ad199ed34c4b9b7b3a740b352731
Zobrazit plný text záznamu
2
Akademický článek
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
Autor: Jung Yoon Park, Mi-Ook Cho, Shanique Leonard, Brent Calder, I Saira Mian, Woo Ho Kim, Susan Wijnhoven, Harry van Steeg, James Mitchell, Gijsbertus T J van der Horst, Jan Hoeijmakers, Pinchas Cohen, Jan Vijg, Yousin Suh
Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2346 (2008)
Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of pr
Externí odkaz: https://doaj.org/article/8f121145a76c467c89138853ded00299
Zobrazit plný text záznamu
3
The regulatory landscapes of human ovarian ageing
Autor: Yousin Suh, Chen Jin, Xizhe Wang, Adam Hudgins, Amir Gamliel, Mingzhuo Pei, Seungsoo Kim, Daniela Contreras, Jan Hoeijmakers, Judith Campisi, Rogerio Lobo, Zev Williams, Michael Rosenfeld
Summary paragraphThe ovary is the first organ to age in the human body, affecting both fertility and overall health in women1-8. However, the biological mechanisms underlying human ovarian ageing remain poorly understood. Here we performed single-nuc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5770283dff4677688b3a6f1690d0a30b
https://doi.org/10.21203/rs.3.rs-1661835/v1
Zobrazit plný text záznamu
6
Abstract 510: Dietary Restriction Improves Vasodilator Dysfunction Caused by Accelerated Vascular Aging Due to Genomic Instability
Autor: Haiyan Wu, Matej Durik, Erwin Reiling, Jan Danser, Jan Hoeijmakers, Martijn Dollé, Anton Roks
Publikováno v: Hypertension. 62
Objective Recently we discovered that genomic instability is associated with accelerated vascular aging in humans and mouse models, and that DNA repair-defective mice ( ERCC1 -/ Δ 7 ) display accelerated age-dependent deterioration of endothelium-de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6f9190c3ea545b9041c6f3b6de97c43
https://doi.org/10.1161/hyp.62.suppl_1.a510
Zobrazit plný text záznamu
7
MicroRNA responses and stress granule formation modulate the DNA damage response
Autor: Joris Pothof, Nicole Verkaik, Jan Hoeijmakers, Dik C. van Gent
Publikováno v: Cell Cycle, 8(21), 3462-3468. Landes Bioscience
EUR Research Portal
DNA damage induced by UV irradiation provokes profound changes in gene expression. Both transcriptional regulation and posttranslational modification of proteins have been known for many years, but the involvement of microRNAs in regulation of mRNA t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::25955c648395f61a57e5b9a330b3c0c1
https://pure.eur.nl/en/publications/c02c6760-089a-4549-a882-488e56a09f6d
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje