Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Jan Hilpert"'
1
Akademický článek
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis
Autor: Jan Hilpert, Esther Groettrup-Wolfers, Hristiyan Kosturski, Laura Bennett, Catriona L. K. Barnes, Kerstin Gude, Isabella Gashaw, Stefanie Reif, Thomas Steger-Hartmann, Christian Scheerans, Alexander Solms, Antje Rottmann, Guangping Mao, Charles Chapron
Publikováno v: Drugs in R&D, Vol 23, Iss 3, Pp 221-237 (2023)
Abstract Introduction BAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology of endometriosis and other disorders. In vivo animal studies suggested a potential therapeutic applica
Externí odkaz: https://doaj.org/article/1369a10efd534cdaa1fd230aeaa2dd33
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2
Akademický článek
First administration of the Fc-attenuated anti-β amyloid antibody GSK933776 to patients with mild Alzheimer's disease: a randomized, placebo-controlled study.
Autor: Niels Andreasen, Monica Simeoni, Henrik Ostlund, Pia I Lisjo, Tormod Fladby, Amy E Loercher, Gerard J Byrne, Frances Murray, Paul T Scott-Stevens, Anders Wallin, Yinghua Y Zhang, Lena H Bronge, Henrik Zetterberg, Agneta K Nordberg, Astrid J Yeo, Shahid A Khan, Jan Hilpert, Prafull C Mistry
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0098153 (2015)
To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).This was a tw
Externí odkaz: https://doaj.org/article/69a0e82640104afeae09379b631cf854
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3
Akademický článek
Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.
Autor: Ian Catchpole, Volker Germaschewski, Jaimie Hoh Kam, Peter Lundh von Leithner, Susannah Ford, Gerald Gough, Peter Adamson, Philip Overend, Jan Hilpert, Francisco J López, Yin Shan Eric Ng, Pete Coffey, Glen Jeffery
Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65518 (2013)
Age-related macular degeneration (AMD) is a leading cause of legal blindness in the Western world. There are effective treatments for the vascular complications of neo-vascular AMD, but no effective therapies are available for the dry/atrophic form o
Externí odkaz: https://doaj.org/article/6539fac7475647f0915a94c21e3d40a3
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8
An adaptive design to investigate the effect of ketoconazole on pharmacokinetics of GSK239512 in healthy male volunteers
Autor: Rajat Mohindra, Jianfeng Xu, Kai Wu, Yanmei Xu, Paul D. Thompson, Benjamin van Hecke, Matt J. B. Davies, Aarti Patel, Jan Hilpert, Gary Collins
Publikováno v: The Journal of Clinical Pharmacology. 55:505-511
This open label drug-drug interaction (DDI) study investigated the effect of a strong CYP3A inhibitor ketoconazole on the PK and safety profile of GSK239512. To mitigate the tolerability concerns of high GSK239512 exposures resulting from CYP3A inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d82678cc23c0164b10d1efbabf5649c
https://doi.org/10.1002/jcph.441
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9
Biological response genes after single dose administration of interferon β-1b to healthy male volunteers
Autor: Susanne Schwenke, Johannes Lampe, Rupert Sandbrink, Joachim Reischl, Jan Hilpert, Kristin Kowal, Jürgen F. Heubach, Johanna M. Beekman, Steffen Stürzebecher, David Bauer
Publikováno v: Journal of Neuroimmunology. 199:115-125
Treatment with interferon β-1b (IFNB-1b) is clinically effective in multiple sclerosis patients. However, the mechanism of action is only partially understood, and validated biological response markers are lacking. We assessed IFNB-1b-induced transc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226206a76314aba59c99ba6f8d7eab6a
https://doi.org/10.1016/j.jneuroim.2008.04.036
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10
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism
Autor: Sebastian Bachmann, Maren Wellner, Torben F Orntoft, Lise Wogensen, Anders Nykjaer, Thomas Thykjaer, Jan Hilpert, Thomas E. Willnow, Uwe Schlichting
Publikováno v: Hilpert, J, Wogensen, L, Andersen, T T, Wellner, M, Schlichting, U, Ørntoft, T F, Bachmann, S, Nykjaer, A & Willnow, T E 2002, ' Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism ', Kidney International, pp. 728-734 .
Hilpert, J, Wogensen, L, Thykjaer, T, Wellner, M, Schlichting, U, Ørntoft, T F, Bachmann, S, Nykjær, A & Willnow, T E 2002, ' Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism ', Kidney International, vol. 62, no. 5, pp. 1672-1681 .
Expression profiling confirms role of endocytic receptor megalin in renal vitamin D 3 metabolism. Background The endocytic receptor megalin constitutes the major pathway for clearance of low-molecular weight plasma proteins from the glomerular filtra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e02c9034a37ed34165a679b2dcfab5
https://doi.org/10.1046/j.1523-1755.2002.00634.x
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