Impact of everolimus plus calcineurin inhibitor on formation of non-HLA antibodies and graft outcomes in kidney transplant recipients: 12-month results from the ATHENA substudy

Autor: Aurélie Philippe, Wolfgang Arns, Vanessa Ditt, Ingeborg A. Hauser, Friedrich Thaiss, Claudia Sommerer, Barbara Suwelack, Duska Dragun, Jan Hillen, Christiane Schiedel, Anja Elsässer, Björn Nashan

Publikováno v: Frontiers in Transplantation, Vol 2 (2023)

BackgroundNon-human leukocyte antigen (non-HLA) antibodies including antibodies targeting Angiotensin II type 1 (AT1R) and Endothelin-1 type A (ETAR) receptors represent a topic of interest in kidney transplantation (KTx). This exploratory substudy e

Externí odkaz: https://doaj.org/article/a06997489cdc43828b88df10c3fff7a5

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

Autor: Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in

Externí odkaz: https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

Autor: Rizi Ai, Uwe Hansen, Johanna Intemann, Elsa Leitão, Toni Weinhage, Isabell Begemann, Joachim Kremerskothen, Anja Römer-Hillmann, Ho-Ryun Chung, Marianne Heitzmann, Thomas Pap, Hermann Pavenstädt, Hans P. Kiener, Na Li, Annika Krause, Wei Wang, Gilles Gasparoni, Berno Dankbar, Sylvia Müller, Corinna Wehmeyer, Denise Beckmann, Dirk Foell, Philip Rosenstiel, Bernhard Horsthemke, Thomas Kamradt, Adelheid Korb-Pap, Karl Nordström, Hans Schnittler, David J. J. de Gorter, Nico Lindemann, Jörn Walter, Gary S. Firestein, Xinyi Yang, Nina Gasparoni, Christopher Schröder, Jan Hillen, Milos Galic

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186d00758ac40be110c81701778639ee
http://europepmc.org/articles/PMC8206096

Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints

Autor: Annika Krause, Ina Winkler, Christiane Geyer, Jan Hillen, Denise Beckmann, Thomas Pap, Marianne Heitzmann, Adelheid Korb-Pap, Christoph Bremer, Hermann Pavenstädt

Publikováno v: Arthritis Research & Therapy

Background Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction to new locations where they reinitiate the destructive processes at distant articular cartilage surfaces. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7460c4c5a8c475b2fe8a7ff627c2e9
https://doi.org/10.1186/s13075-017-1245-9

Displaced midshaft fractures of the clavicle: non-operative treatment versus plate fixation (Sleutel-TRIAL). A multicentre randomised controlled trial

Autor: Jephta van den Bremer, Pieta Krijnen, Inger B. Schipper, Jan Paul M. Frölke, Piet A.R. de Rijcke, Freek D Boekhoudt, Johan G H van den Brand, Bart A. van Dijkman, Stephan W A M van Zutphen, Mark R. de Vries, Niels W. L. Schep, G.R. Roukema, M.W.G.A. Bronkhorst, Jan W Duijff, Sylvia A. Stegeman, Nicolaj M R Soesman, Cornelis F. M. Sier, Tom P H Van Thiel, Hub G W M Van der Meulen, Mireille de Jong, M.G. Eversdijk, Andras F K Tanka, Dagmar I Vos, Robert Jan Hillen, Tjebbe Hagenaars, Ger D J van Olden

Publikováno v: BMC Musculoskeletal Disorders
BMC Musculosketal Disorders, 12. BioMed Central
BMC Musculoskeletal Disorders, 12, 196-196
BMC Musculoskeletal Disorders, 12, pp. 196-196
BMC musculoskeletal disorders, 12. BioMed Central
BMC Musculoskeletal Disorders, Vol 12, Iss 1, p 196 (2011)
BMC Musculoskeletal Disorders, 12. BioMed Central Ltd.
BMC Musculoskeletal Disorders, 12

Background The traditional view that the vast majority of midshaft clavicular fractures heal with good functional outcomes following non-operative treatment may be no longer valid for all midshaft clavicular fractures. Recent studies have presented a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53398fa941d3c1b4348fcca7a17ae545
https://hdl.handle.net/11245/1.365245