Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jan Hellert"'
Autor:
Samantha Hover, Frank W. Charlton, Jan Hellert, Jessica J. Swanson, Jamel Mankouri, John N. Barr, Juan Fontana
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Following endocytosis, enveloped viruses employ the changing environment of maturing endosomes as cues to promote endosomal escape, a process often mediated by viral glycoproteins. We previously showed that both high [K+] and low pH promote
Externí odkaz:
https://doaj.org/article/89f71ba3dc2a4843a816c001509db607
Autor:
Jan H. Forth, Sten Calvelage, Melina Fischer, Jan Hellert, Julia Sehl-Ewert, Hanna Roszyk, Paul Deutschmann, Adam Reichold, Martin Lange, Hans-Hermann Thulke, Carola Sauter-Louis, Dirk Höper, Svitlana Mandyhra, Maryna Sapachova, Martin Beer, Sandra Blome
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTAfrican swine fever virus (ASFV), a large and complex DNA-virus circulating between soft ticks and indigenous suids in sub-Saharan Africa, has made its way into swine populations from Europe to Asia. This virus, causing a severe haemorrhagic
Externí odkaz:
https://doaj.org/article/b6e261dcf37d4ecba9a7cee3b149b81a
Autor:
Jan Hellert, Andrea Aebischer, Ahmed Haouz, Pablo Guardado-Calvo, Sven Reiche, Martin Beer, Félix A. Rey
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112142- (2023)
Summary: La Crosse virus, responsible for pediatric encephalitis in the United States, and Schmallenberg virus, a highly teratogenic veterinary virus in Europe, belong to the large Orthobunyavirus genus of zoonotic arthropod-borne pathogens distribut
Externí odkaz:
https://doaj.org/article/646c3a5a00824e27b95900d38642455a
Autor:
Jan Hellert, Julian Buchrieser, Florence Larrous, Andrea Minola, Guilherme Dias de Melo, Leah Soriaga, Patrick England, Ahmed Haouz, Amalio Telenti, Olivier Schwartz, Davide Corti, Hervé Bourhy, Félix A. Rey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Rabies virus (RABV) infection of unvaccinated individuals can be treated with post exposure prophylaxis. Here, Hellert et al. analyze the structure of a broadly neutralizing human antibody in complex with its target domain in the RABV glycoprotein an
Externí odkaz:
https://doaj.org/article/e6bafc79f9814357b005d33b29f35294
Autor:
Jan Hellert, Andrea Aebischer, Kerstin Wernike, Ahmed Haouz, Emiliana Brocchi, Sven Reiche, Pablo Guardado-Calvo, Martin Beer, Félix A. Rey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that
Externí odkaz:
https://doaj.org/article/2104c270a93148418cef93bdd6763c5f
Autor:
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas
Publikováno v:
eLife, Vol 9 (2020)
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a br
Externí odkaz:
https://doaj.org/article/77e72f756264423fbde716e30e5a2df1
Autor:
Jan Hellert, Magdalena Weidner-Glunde, Joern Krausze, Ulrike Richter, Heiko Adler, Roman Fedorov, Marcel Pietrek, Jessica Rückert, Christiane Ritter, Thomas F Schulz, Thorsten Lührs
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003640 (2013)
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and causes several malignancies in humans. Murine herpesvirus 68 (MHV-68) is a related γ2-herpesvirus frequently used as a model to study the biology of γ-herpesvi
Externí odkaz:
https://doaj.org/article/b6ce63ee0f1f4a07b014395c34b3a3d9
Autor:
Jan H. Forth, Sten Calvelage, Melina Fischer, Jan Hellert, Julia Sehl-Ewert, Hanna Roszyk, Paul Deutschmann, Adam Reichold, Martin Lange, Hans-Hermann Thulke, Carola Sauter-Louis, Dirk Höper, Svitlana Mandyhra, Maryna Sapachova, Martin Beer, Sandra Blome
Publikováno v:
Emerging Microbes & Infections. 12
African swine fever virus (ASFV), a large and complex DNA-virus circulating between soft ticks and indigenous suids in sub-Saharan Africa, has made its way into swine populations from Europe to Asia. This virus, causing a severe haemorrhagic disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc30e38eefb6a116e2ff9429bc9f97ee
https://doi.org/10.1080/22221751.2022.2146537
https://doi.org/10.1080/22221751.2022.2146537
Following internalisation, viruses employ the changing environment of maturing endosomes as cues to promote endosomal escape, a process mediated by viral glycoproteins. Specifically, we previously showed that both high [K+] and low pH promote entry o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc3cabb4501af2b135a079194f5f3b1
https://doi.org/10.1101/2022.08.11.503604
https://doi.org/10.1101/2022.08.11.503604
Autor:
Akaash K. Mishra, Jan Hellert, Natalia Freitas, Pablo Guardado-Calvo, Ahmed Haouz, J. Maximilian Fels, Daniel P. Maurer, Dafna M. Abelson, Zachary A. Bornholdt, Laura M. Walker, Kartik Chandran, François-Loïc Cosset, Jason S. McLellan, Felix A. Rey
Publikováno v:
iScience
iScience, 2022, 375 (6576), pp.104-109. ⟨10.1126/science.abl6502⟩
Science
iScience, 2022, 375 (6576), pp.104-109. ⟨10.1126/science.abl6502⟩
Science
International audience; Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-borne zoonotic virus, with a 30% case fatality rate in humans. Structural information is lacking in regard to the CCHFV membrane fusion glycoprotein Gc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832e0b17edfb1cec023cc14b7cba949b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03525373
https://hal-pasteur.archives-ouvertes.fr/pasteur-03525373