Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jan Haviernik"'
Autor:
Pavel Svoboda, Jan Haviernik, Petr Bednar, Milos Matkovic, Tomás Cervantes Rincón, Jennifer Keeffe, Martin Palus, Jiri Salat, Marianna Agudelo, Michel C. Nussenzweig, Andrea Cavalli, Davide F. Robbiani, Daniel Ruzek
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113149- (2023)
Summary: Tick-borne encephalitis virus (TBEV) is a flavivirus that causes human neuroinfections and represents a growing health problem. The human monoclonal antibody T025 targets envelope protein domain III (EDIII) of TBEV and related tick-borne fla
Externí odkaz:
https://doaj.org/article/b7351abf009441de9b874b9fa9404a57
Autor:
Ádám Kevély, Veronika Prančlová, Monika Sláviková, Jan Haviernik, Václav Hönig, Eva Nováková, Martin Palus, Daniel Růžek, Boris Klempa, Juraj Koči
Publikováno v:
Viruses, Vol 14, Iss 12, p 2673 (2022)
The tick-borne encephalitis virus (TBEV) causes a most important viral life-threatening illness transmitted by ticks. The interactions between the virus and ticks are largely unexplored, indicating a lack of experimental tools and systematic studies.
Externí odkaz:
https://doaj.org/article/bf205562869c4d739893b5b6f4303172
Autor:
Michal Štefánik, Dattatry Shivajirao Bhosale, Jan Haviernik, Petra Straková, Martina Fojtíková, Lucie Dufková, Ivana Huvarová, Jiří Salát, Jan Bartáček, Jan Svoboda, Miloš Sedlák, Daniel Růžek, Andrew D. Miller, Luděk Eyer
Publikováno v:
Viruses, Vol 14, Iss 2, p 354 (2022)
Diphyllin is a natural arylnaphtalide lignan extracted from tropical plants of particular importance in traditional Chinese medicine. This compound has been described as a potent inhibitor of vacuolar (H+)ATPases and hence of the endosomal acidificat
Externí odkaz:
https://doaj.org/article/0ab86865f7c045cc8d5055abaf679ca9
Autor:
Jiří Holoubek, Klára Bednářová, Jan Haviernik, Ivana Huvarová, Zuzana Dvořáková, Jiří Černý, Martina Outlá, Jiří Salát, Eva Konkol'ová, Evzen Boura, Daniel Růžek, Michaela Vorlíčková, Luděk Eyer, Daniel Renčiuk
Publikováno v:
Nucleic Acids Research. 50:4574-4600
We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human infections and numerous deaths every year. The formation of G4s was confirmed by biophysica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6eefa99f8d290e73c1d15b02866282f
https://doi.org/10.1093/nar/gkac225
https://doi.org/10.1093/nar/gkac225
Publikováno v:
Microorganisms, Vol 9, Iss 3, p 471 (2021)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of the pandemic coronavirus disease 2019 (COVID-19), which has resulted in over two million deaths worldwide to date. Diphyllin and diphyllinosides are known as natural
Externí odkaz:
https://doaj.org/article/2f6fab6b65da4bf48d4cfa8868b6c4a9
Autor:
Michal Stefanik, Fortunatus C Ezebuo, Jan Haviernik, Ikemefuna C. Uzochukwu, Martina Fojtikova, Jiri Salat, Ludek Eyer, Daniel Ruzek
Publikováno v:
Proceedings, Vol 50, Iss 1, p 6 (2020)
Arthropod-borne flaviviruses such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Zika virus (ZIKV), Dengue virus (DENV), and yellow fever virus (YFV) cause several serious life-threatening syndromes (encephalitis, miscarriages, paral
Externí odkaz:
https://doaj.org/article/5ba585406cd647bea0d0bed8bca90834
Autor:
Jan Haviernik, Ludek Eyer, Antoine Nougairède, Marie Uhlířová, Jean-Sélim Driouich, Darina Zouharová, James Jason Valdés, Ernest Gould, Erik De Clercq, Xavier de Lamballerie, Daniel Ruzek
Publikováno v:
Proceedings, Vol 50, Iss 1, p 12 (2020)
Tick-borne encephalitis virus (TBEV) is a pathogen that causes severe human neuroinfections in Europe and Asia for which there is currently no specific therapy. The adenosine analogue galidesivir (BCX4430), a broad-spectrum RNA virus inhibitor, has e
Externí odkaz:
https://doaj.org/article/6e3341d7d4ed4d5187eeb0abbf4af128
Autor:
Michal Stefanik, James J. Valdes, Fortunatus C. Ezebuo, Jan Haviernik, Ikemefuna C. Uzochukwu, Martina Fojtikova, Jiri Salat, Ludek Eyer, Daniel Ruzek
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 599 (2020)
Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S. Food and Drug Administration-approved ant
Externí odkaz:
https://doaj.org/article/aeee10316a554a17882b166a2eaec000
Autor:
Jiri Salat, Kamil Mikulasek, Osmany Larralde, Petra Pokorna Formanova, Ales Chrdle, Jan Haviernik, Jana Elsterova, Dana Teislerova, Martin Palus, Ludek Eyer, Zbynek Zdrahal, Juraj Petrik, Daniel Ruzek
Publikováno v:
Vaccines, Vol 8, Iss 1, p 81 (2020)
Vaccination against tick-borne encephalitis (TBE) is based on the use of formalin-inactivated, culture-derived whole-virus vaccines. Immune response following vaccination is primarily directed to the viral envelope (E) protein, the major viral surfac
Externí odkaz:
https://doaj.org/article/d7efa593a6a34f31bc9b934ddefe33fb
Autor:
Michal Strouhal, Lenka Mikalová, Jan Haviernik, Sascha Knauf, Sylvia Bruisten, Gerda T Noordhoek, Jan Oppelt, Darina Čejková, David Šmajs
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006867 (2018)
BACKGROUND:Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multistage disease endemic in tropical regions in Africa, Asia, Oceania, and South America. To date, seven TPE strains have been completely sequenced and analyzed i
Externí odkaz:
https://doaj.org/article/bea44b12a3844e27a2ac042eb93458e7