Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jan H. Voß"'
Autor:
Tobias Claff, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Renato H. Weiße, Robert K. Y. Cheng, Sandra Markovic-Mueller, Denis Bucher, Norbert Sträter, Christa E. Müller
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The Gs protein-coupled adenosine A2A receptor (A2AAR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was developed as an A2AAR antagonist with ancillary blockade of the A2BAR subtype. It cons
Externí odkaz:
https://doaj.org/article/be5089b2d60c4f06bb110f0f415664ab
Autor:
Jan H. Voss, Max Crüsemann, Christian R.O. Bartling, Stefan Kehraus, Asuka Inoue, Gabriele M. König, Kristian Strømgaard, Christa E. Müller
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106492- (2023)
Summary: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and FR derivativ
Externí odkaz:
https://doaj.org/article/2a7281d6a7c5400a9b68ae13982ff5b1
Autor:
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 57 (2022)
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., as
Externí odkaz:
https://doaj.org/article/ab51b259cd79400aa01e768efdd94017
Autor:
Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E. Müller
Publikováno v:
Molecules, Vol 27, Iss 12, p 3792 (2022)
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based on an 8-p-sulfophenylxanthine
Externí odkaz:
https://doaj.org/article/d0d8be1988af4d15968751ab4b7f458a
Autor:
Markus Kuschak, Jonathan G. Schlegel, Marion Schneider, Stefan Kehraus, Jan H. Voss, Alexander Seidinger, Michaela Matthey, Daniela Wenzel, Bernd K. Fleischmann, Gabriele M. König, Christa E. Müller
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor. It is a powerful tool to study G protein-coupled receptor signaling, and has potential as a
Externí odkaz:
https://doaj.org/article/6d26f3ec3564426da79c7c7a215893fe
Autor:
Wiebke Hanke, Raphael Reher, Christa E. Müller, Evi Kostenis, Gabriele M. König, Jung Bong Kim, Stefan Kehraus, Max Crüsemann, Julian Patt, Judith Alenfelder, Vigneshwaran Namasivayam, Mitja M Zdouc, Goran Vuk Grujicic, Jan H. Voss
Publikováno v:
Journal of Natural Products. 84:1941-1953
Both the soil bacterium Chromobacterium vaccinii and the bacterial endosymbiont Candidatus Burkholderia crenata of the plant Ardisia crenata are producers of FR900359 (FR). This cyclic depsipeptide is a potent and selective Gq protein inhibitor used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09ecc71cfc0a46eaf6adf701be381175
https://doi.org/10.1021/acs.jnatprod.1c00194
https://doi.org/10.1021/acs.jnatprod.1c00194
Autor:
Daniela Wenzel, Gabriele M. König, Alexander Seidinger, Jan H. Voss, Markus Kuschak, Christa E. Müller, Marion Schneider, Jonathan G. Schlegel, Michaela Matthey, Mariam Tahoun, Stefan Kehraus, Bernd K. Fleischmann
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. While GPCRs represent the largest class of drug targets, G protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225c83b0545b1431ba26b740f0a791b5
https://doi.org/10.1021/acsptsci.1c00021
https://doi.org/10.1021/acsptsci.1c00021
Autor:
Müller, Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E.
Publikováno v:
Molecules; Volume 27; Issue 12; Pages: 3792
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based on an 8-p-sulfophenylxanthine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9d64842034867f0c974a7b7b02269c69
Autor:
Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam, Victoria J. Vaaßen, Jonathan G. Schlegel, Christin Vielmuth, Jan H. Voß, Jörg Labahn, Christa E. Müller
Publikováno v:
Angewandte Chemie. 134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f3c2664b6eb290a1abde2a15ddc8466
https://doi.org/10.1002/ange.202205120
https://doi.org/10.1002/ange.202205120
Autor:
Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam, Victoria J. Vaaßen, Jonathan G. Schlegel, Christin Vielmuth, Jan H. Voß, Jörg Labahn, Christa E. Müller
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0aab86584216502bfa4cd6332368d36
https://doi.org/10.1002/anie.202205120
https://doi.org/10.1002/anie.202205120