Výsledky vyhledávání - "Jan H. Toersche"

Quantitative bottom up analysis of infliximab in serum using protein A purification and integrated μLC-electrospray chip IonKey MS/MS technology

Autor: Frédérique L. van Holthoon, Jan H. Toersche, Martha Ingola, William D van Dongen, Anne J. Kleinnijenhuis

Publikováno v: Bioanalysis. 8:891-904

Background: TNO Triskelion has applied its general workflow for the development of quantitative LC–MS methods for proteins in biological matrices to the quantification of infliximab in rat serum using bottom up μLC–MS/MS. Results/methodology: Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0457da3ac4093ff4d53d4645c5172fd8
https://doi.org/10.4155/bio-2015-0015

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A generic sample preparation approach for LC–MS/MS bioanalysis of therapeutic monoclonal antibodies in serum applied to Infliximab

Autor: WD van Dongen, FL van Holthoon, Jan H. Toersche, Anne J. Kleinnijenhuis, Richard C. Bas

Publikováno v: Journal of Applied Bioanalysis, Vol 1, Iss 1, Pp 26-34 (2015)

In this study, we developed a generic bioanalytical workflow providing sensitive, specific, and accurate absolute quantification of therapeutic monoclonal antibodies in serum. The workflow involves magnetic beads coated with protein A to pull-down th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5efd2a0805cd723a3f6986f31b8757
https://doi.org/10.17145/jab.15.005

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