Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jan H. N. Lindeman"'
Autor:
Onur B. Dolmaci, Robert J. M. Klautz, Robert E. Poelmann, Jan H. N. Lindeman, Ralf Sprengers, Lucia Kroft, Nimrat Grewal
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Introduction Bicuspid aortic valve (BAV) patients have an increased risk to develop thoracic aortic complications. Little is known about the prevalence and severity of atherosclerosis in the BAV ascending aortic wall. This study evaluates an
Externí odkaz:
https://doaj.org/article/502b9a7f321c40d9afd2c63c745a952c
Autor:
Onur B. Dolmaci, Tugay Ayyildiz, Robert E. Poelmann, Antoine H. G. Driessen, Dave R. Koolbergen, Robert J. M. Klautz, Jan H. N. Lindeman, Nimrat Grewal
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
ObjectivePatients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic complications.
Externí odkaz:
https://doaj.org/article/85a8f9f47c1644d29597175c34d79563
Autor:
Gabor Gäbel, Bernd H. Northoff, Amanda Balboa, Mediha Becirovic‐ Agic, Marcelo Petri, Albert Busch, Lars Maegdefessel, Adrian Mahlmann, Stefan Ludwig, Daniel Teupser, Vivian de Waard, Jonathan Golledge, Anders Wanhainen, Dick Wågsäter, Lesca M. Holdt, Jan H. N. Lindeman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Background While numerous interventions effectively interfered with abdominal aortic aneurysm (AAA) formation/progression in preclinical models, none of the successes translated into clinical success. Hence, a systematic exploration of parallel and d
Externí odkaz:
https://doaj.org/article/c5e429062f6d429b954ba264ac7628c9
Autor:
Onur B. Dolmaci, Juno Legué, Jan H. N. Lindeman, Antoine H. G. Driessen, Robert J. M. Klautz, Thomas J. Van Brakel, Hans‐Marc J. Siebelink, Bart J. A. Mertens, Robert E. Poelmann, Adriana C. Gittenberger‐de Groot, Nimrat Grewal
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 12 (2021)
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with com
Externí odkaz:
https://doaj.org/article/fb76539dad194f9d80a0b365c33b104c
Autor:
Laura E. Bruijn, Brendy E. W. M. van den Akker, Connie M. van Rhijn, Jaap F. Hamming, Jan H. N. Lindeman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 23 (2020)
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as “fibroblasts,” “myofibroblast
Externí odkaz:
https://doaj.org/article/e770b3ed499149389de4da0dd72a836c
Autor:
Till Seime, Asim Cengiz Akbulut, Moritz Lindquist Liljeqvist, Antti Siika, Hong Jin, Greg Winski, Rick H. van Gorp, Eva Karlöf, Mariette Lengquist, Andrew J. Buckler, Malin Kronqvist, Olivia J. Waring, Jan H. N. Lindeman, Erik A. L. Biessen, Lars Maegdefessel, Anton Razuvaev, Leon J. Schurgers, Ulf Hedin, Ljubica Matic
Publikováno v:
Cells, Vol 10, Iss 6, p 1276 (2021)
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcif
Externí odkaz:
https://doaj.org/article/4155e028a38249d0a8d83187cd4edff6
Autor:
Nimrat Grewal, Bart J. J. Velders, Adriana C. Gittenberger-de Groot, Robert Poelmann, Robert J. M. Klautz, Thomas J. Van Brakel, Jan H. N. Lindeman
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 2, p 12 (2021)
(1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall s
Externí odkaz:
https://doaj.org/article/8f7adedca2714adfa2a0c356d7833e57
Autor:
Gabor Gäbel, Bernd H. Northoff, Irina Weinzierl, Stefan Ludwig, Irene Hinterseher, Wolfgang Wilfert, Daniel Teupser, Stefan A. Doderer, Hendrik Bergert, Frank Schönleben, Jan H. N. Lindeman, Lesca M. Holdt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundClinical decision making in abdominal aortic aneurysms (AAA) relies completely on diameter. At this point, improved decision tools remain an unmet medical need. Our goal was to identify changes at the molecular level specifically leading up
Externí odkaz:
https://doaj.org/article/85d16c11dc8c4e9cbc17c12c2c5b1c9d
Autor:
Rogier A. van Dijk, Kevin Rijs, Anouk Wezel, Jaap F. Hamming, Frank D. Kolodgie, Renu Virmani, Alexander F. Schaapherder, Jan H. N. Lindeman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)
BackgroundThe concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although current insights to this process are largely based on murine models, there are fundamental differ
Externí odkaz:
https://doaj.org/article/ca207222b0744e95aeffcbfefe359ec6
Autor:
David Freiholtz, Otto Bergman, Karin Lång, Flore-Anne Poujade, Valentina Paloschi, Carl Granath, Jan H. N. Lindeman, Christian Olsson, Anders Franco-Cereceda, Per Eriksson, Hanna M. Björck
Publikováno v:
Journal of Molecular Medicine.
Abstract Bicuspid aortic valve (BAV) is the most common congenital heart malformation frequently associated with ascending aortic aneurysm (AscAA). Epithelial to mesenchymal transition (EMT) may play a role in BAV-associated AscAA. The aim of the stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccf5ccca43162289f854857cfb7acaca
https://doi.org/10.1007/s00109-023-02316-5
https://doi.org/10.1007/s00109-023-02316-5