Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jan H. Hoeijmakers"'
Autor:
Steven Bergink, Lies-Anne Severijnen, Nils Wijgers, Kaoru Sugasawa, Humaira Yousaf, Johan M. Kros, John van Swieten, Ben A. Oostra, Jan H. Hoeijmakers, Wim Vermeulen, Rob Willemsen
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 3, Pp 708-716 (2006)
Intracellular inclusions play a profound role in many neurodegenerative diseases. Here, we report that HR23B and HR23A, proteins that are involved in both DNA repair and shuttling proteins to the 26S proteasome for degradation, accumulate in neuronal
Externí odkaz:
https://doaj.org/article/3745910c010e4c4ea7ef66e775436bb7
Autor:
Jan H Hoeijmakers
Publikováno v:
Cancer Research. 83:IA001-IA001
Rare DNA repair syndromes display strong cancer predisposition and/or premature aging, indicating that DNA damage underlies both, consistent with the notion that age is the most important risk factor for cancer. We have generated a series of DNA-repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c825b0f70916facce0c564f1c1ab313
https://doi.org/10.1158/1538-7445.agca22-ia001
https://doi.org/10.1158/1538-7445.agca22-ia001
Autor:
Erwin Reiling, Martijn E T Dollé, Sameh A Youssef, Moonsook Lee, Bhawani Nagarajah, Marianne Roodbergen, Piet de With, Alain de Bruin, Jan H Hoeijmakers, Jan Vijg, Harry van Steeg, Paul Hasty
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93568 (2014)
Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. Ho
Externí odkaz:
https://doaj.org/article/4ea8161befee4fbc84c4cdd146c34eb2
Autor:
Martine de Boer, Maaike te Lintel Hekkert, Marion G de Kleijnen, Daphne Merkus, Jan H Hoeijmakers, Dirk J Duncker
Publikováno v:
Circulation. 136
Background & Hypothesis: The exact molecular mechanisms underlying the pathogenesis of heart failure (HF) remain incompletely understood hampering a more mechanism-based approach to effective treatment and prevention. Every cell contains DNA repair s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf7f27a5de7a4837b8ba57ef67441c0
https://doi.org/10.1161/circ.136.suppl_1.20900
https://doi.org/10.1161/circ.136.suppl_1.20900