Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion.

Autor: Pei-Shang Wu, Jan Grosser, Donald P Cameron, Laura Baranello, Lena Ström

Publikováno v: PLoS Genetics, Vol 17, Iss 9, p e1009763 (2021)

The structural maintenance of chromosome (SMC) complex cohesin mediates sister chromatid cohesion established during replication, and damage-induced cohesion formed in response to DSBs post-replication. The translesion synthesis polymerase Polη is r

Externí odkaz: https://doaj.org/article/a3d88a91aed548d38e29c534e4bbc1f5

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

Autor: Alice Meroni, Jan Grosser, Sumedha Agashe, Natasha Ramakrishnan, Jessica Jackson, Priyanka Verma, Laura Baranello, Alessandro Vindigni

Publikováno v: Science Advances. 8

DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a324f0bb62f1bb303b797682634faf40
https://doi.org/10.1126/sciadv.abq0648

Detection of Microorganisms with an Electronic Nose for Application under Microgravity Conditions

Autor: Ulrich Reidt, Jan Grosser, S. N. Kharin, Andreas Helwig, Joachim Lenic, Gerhard Dr. Müller, Andrei Kornienko, Viktor Fetter, Thomas Hummel, N. M. Novikova

Publikováno v: Gravitational and Space Research. 8:1-17

In this work, we report on the construction, training and functional assessment of an electronic nose (called ‘E-Nose’) that is capable of monitoring the microbial contamination onboard space ships under microgravity conditions. To this end, a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cad14e4daa1311d1b5aed09c6f39951b
https://doi.org/10.2478/gsr-2020-0001

The assisting role of Polη in transcription facilitates formation of damage-induced cohesion

Autor: Laura Baranello, Donald P. Cameron, Lena Ström, Jan Grosser, Pei-Shang Wu

The structural maintenance of chromosome (SMC) complex cohesin mediates sister chromatid cohesion established during replication, and damage-induced cohesion formed in response to DSBs post-replication. The translesion synthesis polymerase Polη is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96f57c7911d3b935d3efc0ca4b86956a
https://doi.org/10.1101/2020.12.20.423707

Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

Autor: Roberto Ballarino, Toyoaki Natsume, Laura Baranello, Rashid Mehmood, Radosław Grochowski, Anika Wiegard, Jan Grosser, Michele Ceribelli, Donald P. Cameron, Anna H. Bizard, Fedor Kouzine, Nicola Crosetto, Vladislav Kuzin, Arne Lindqvist, Ivana Karabogdan, Francesco Valant

Publikováno v: Wiegard, A, Kuzin, V, Cameron, D P, Grosser, J, Ceribelli, M, Mehmood, R, Ballarino, R, Valant, F, Grochowski, R, Karabogdan, I, Crosetto, N, Lindqvist, A, Bizard, A H, Kouzine, F, Natsume, T & Baranello, L 2021, ' Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1 ', Molecular Cell, vol. 81, no. 24, pp. 5007-5024.e9 . https://doi.org/10.1016/j.molcel.2021.10.015

As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it is removed by DNA topoisomeras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2285bb0b44adcf14340fca481f1e79
https://doi.org/10.1016/j.molcel.2021.10.015