Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Jan Groeneveld"'
Publikováno v:
Sensors, Vol 24, Iss 6, p 1756 (2024)
The moisture content within the concrete pore network significantly influences the mechanical, thermal, and durability characteristics of concrete structures. This paper introduces a novel fully embedded wireless temperature and relative humidity sen
Externí odkaz:
https://doaj.org/article/4571dbef93a64931a28d03cb442401e1
Autor:
Titia Q. Ruijs, Ingrid W. Koopmans, Marieke L. deKam, Martijn R. Tannemaat, Geert Jan Groeneveld, Jules A. A. C. Heuberger
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 12, Pp 2971-2981 (2022)
Abstract Measuring muscle velocity recovery cycles (MVRCs) is a method to obtain information on muscle cell excitability, independent of neuromuscular transmission. The goal was to validate MVRC as a pharmacodynamic (PD) biomarker for drugs targeting
Externí odkaz:
https://doaj.org/article/846b2acafe414937999174590a47332b
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-9 (2022)
Abstract Background This study investigated plasma biomarkers for neuroinflammation associated with Alzheimer’s disease (AD) in subjects with preclinical AD compared to healthy elderly. How these biomarkers behave in patients with AD, compared to h
Externí odkaz:
https://doaj.org/article/8910cd9054ca41a2a22f12c4033ad9db
Autor:
Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 2010-2023 (2022)
Abstract RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to
Externí odkaz:
https://doaj.org/article/b9ff23b0f0ad4f13a0f534eb7f32e626
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 981-993 (2022)
Abstract Selective inhibition of certain voltage‐gated sodium channels (Navs), such as Nav1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neu
Externí odkaz:
https://doaj.org/article/78f4b743b5cc4db5bbdbb4ef4828e4bf
Autor:
Kawita M. S. Kanhai, Sebastiaan C. Goulooze, Jeroen van derGrond, Amy C. Harms, Thomas Hankemeier, Ajay Verma, Gersham Dent, Juan Chavez, Henri Meijering, Geert Jan Groeneveld
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 3, Pp 638-648 (2022)
Abstract The majority of disease modifying therapies for multiple sclerosis (MS) reduce inflammation, but do no’t target remyelination. Development of remyelinating therapies will benefit from a method to quantify myelin kinetics in patients with M
Externí odkaz:
https://doaj.org/article/5358ac60b285488599efc13f34251e3e
Autor:
Boudewijn T. H. M. Sleutjes, Diederik J. L. Stikvoort García, Maria O. Kovalchuk, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H. van denBerg
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Altered motor neuron excitability in patients with amyotrophic lateral sclerosis (ALS) has been suggested to be an early pathophysiological mechanism associated with motor neuron death. Compounds that affect membrane excitability may therefo
Externí odkaz:
https://doaj.org/article/5c0e5d870801415794f7270ca97223fa
Autor:
Igor Radanovic, Naomi Klarenbeek, Robert Rissmann, Geert Jan Groeneveld, Emilie M. J. van Brummelen, Matthijs Moerland, Jacobus J. Bosch
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
AimTraditionally, early phase clinical trials in oncology have been performed in patients based on safety risk-benefit assessment. Therapeutic transition to immuno-oncology may open new opportunities for studies in healthy volunteers, which are condu
Externí odkaz:
https://doaj.org/article/05c5b23e725044ca9151f80660d82f26
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background In the current study, we aimed to develop an algorithm based on biomarkers obtained through non- or minimally invasive procedures to identify healthy elderly subjects who have an increased risk of abnormal cerebrospinal fluid (CSF
Externí odkaz:
https://doaj.org/article/a7689931f0644552b7feafa5d357d2b7
Autor:
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Demen
Externí odkaz:
https://doaj.org/article/8f25b2ca13ee46c9988b118de2ad5f58