Výsledky vyhledávání - "Jan G. J. van de Winkel"

Akademický článek

IgA EGFR antibodies mediate tumour killing in vivo

Autor: Peter Boross, Stefan Lohse, Maaike Nederend, Johannes Hendrik Marco Jansen, Geert van Tetering, Michael Dechant, Matthias Peipp, Louise Royle, Li Phing Liew, Louis Boon, Nico van Rooijen, Wim K. Bleeker, Paul W. H. I. Parren, Jan G. J. van de Winkel, Thomas Valerius, Jeanette H. W. Leusen

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 8, Pp 1213-1226 (2013)

Abstract Currently all approved anti‐cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by

Externí odkaz: https://doaj.org/article/329d97c0f4a14fd1a47447646d3dc7c0

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Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells

Autor: Paul W. H. I. Parren, Marleen Voorhorst, Patrick J. Engelberts, Tom Vink, Frank J. Beurskens, Thomas Valerius, Wendy J.M. Mackus, Joost M. Bakker, Stefanie Derer, Tom van Meerten, Esther C.W. Breij, Janine Schuurman, Jan G. J. van de Winkel

Publikováno v: Engelberts, P J, Voorhorst, M, Schuurman, J, Van Meerten, T, Bakker, J M, Vink, T, Mackus, W J M, Breij, E C W, Derer, S, Valerius, T, van de Winkel, J G J, Parren, P W H I & Beurskens, F J 2016, ' Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells ', Journal of Immunology, vol. 197, no. 12, pp. 4829-4837 . https://doi.org/10.4049/jimmunol.1600811
Journal of Immunology, 197(12), 4829-4837. AMER ASSOC IMMUNOLOGISTS

Human IgG1 type I CD20 Abs, such as rituximab and ofatumumab (OFA), efficiently induce complement-dependent cytotoxicity (CDC) of CD20+ B cells by binding of C1 to hexamerized Fc domains. Unexpectedly, we found that type I CD20 Ab F(ab')2 fragments,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d9197ec28f899d5e6a016465f31efa
https://portal.findresearcher.sdu.dk/da/publications/34aca668-9af2-49ed-945c-3a69d108b381

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Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity

Autor: Jan G. J. van de Winkel, Paul W. H. I. Parren, Daniela Hallack, Christian Kellner, Thomas Valerius, Tina Maurer, Martin Gramatzki, Matthias Peipp, Andreas Humpe, Roland Repp

Publikováno v: The Journal of Immunology. 189:5037-5046

Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination of stressed cells. A fusion protein consisting of the ectodomain of B7-H6 and the CD20 single-chain fragment variable 7D8 was generated to mimic an induced sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bda18d391894f717e7d8878deb22a2
https://doi.org/10.4049/jimmunol.1201321

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Enhanced FcαRI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells

Autor: Marjolein van Egmond, Marielle A. Otten, Jantine E. Bakema, Alison L. Tutt, Jan G. J. van de Winkel, Cornelis W. Tuk, Martin J. Glennie, R.H.J. Beelen

Publikováno v: European Journal of Immunology. 42:1815-1821

Neutrophils potently kill tumour cells in the presence of anti-tumour antibodies in vitro. However, for in vivo targeting, the neutrophils need to extravasate from the circulation by passing through endothelial barriers. To study neutrophil migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04d3b52cc3bc5fe9045891c664486491
https://doi.org/10.1002/eji.201141982

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Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

Autor: Paul W. H. I. Parren, Ronald P. Taylor, Elizabeth M. Peek, Paul V. Beum, Frank J. Beurskens, Jan G. J. van de Winkel, Margaret A. Lindorfer, Patrick J. Engelberts

Publikováno v: Journal of Immunology, 187(6), 3438-3447. AMER ASSOC IMMUNOLOGISTS

We previously reported that 1 h after infusion of CD20 mAb rituximab in patients with chronic lymphocytic leukemia (CLL), >80% of CD20 was removed from circulating B cells, and we replicated this finding, based on in vitro models. This reaction occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a0a9437a27bfeba3ac87b361bd05f9
https://doi.org/10.4049/jimmunol.1101189

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

Autor: Stefan Loverix, Ignace Lasters, Janine Schuurman, Rebecca J. Rose, Aran F. Labrijn, Albert J. R. Heck, Paul W. H. I. Parren, Patrick Van Berkel, Ewald T. J. van den Bremer, Jan G. J. van de Winkel

Publikováno v: Structure, 19(9), 1274-1282. CELL PRESS

Native mass spectrometry (MS) is a powerful technique for studying noncovalent protein-protein interactions. Here, native MS was employed to examine the noncovalent interactions involved in homodimerization of antibody half molecules (HL) in hinge-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7390d4315c6757b314b2afe7723fe31
https://doi.org/10.1016/j.str.2011.06.016

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Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII)

Autor: Paul W. H. I. Parren, Thomas Valerius, Sven Berger, Jeroen J. Lammerts van Bueren, Katja Klausz, Michael Dechant, Matthias Peipp, Stefanie Derer, Jan G. J. van de Winkel, Stefan Lohse

Publikováno v: Cancer Science. 102:1761-1768

Monoclonal antibodies (mAb) against variant III of epidermal growth factor receptor (EGFRvIII) hold promise for improving tumor selectivity of EGFR-targeted therapy. Here, we compared Fc-mediated effector functions of three mAb against EGFRvIII (MR1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e436ba3145b391cc7990cbab8912655
https://doi.org/10.1111/j.1349-7006.2011.02019.x

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c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcRγ-chain

Autor: Gosse J. Adema, Jan G. J. van de Winkel, Jantine E. Bakema, Paul J. Coffer, Jeanette H. W. Leusen, Marjolein van Egmond, Yvonne Kok, Simone de Haij, J. M. Bakker, Ida H. Hiemstra

Publikováno v: European Journal of Immunology, 40(7), 2035-2040. Wiley-VCH Verlag
European Journal of Immunology, 40, 7, pp. 2035-40
Bakema, J E, Hiemstra, I H, Bakker, J, de Haij, S, Kok, Y, Adema, G, van Egmond, M, Coffer, PJ, Winkel, J G J & Leusen, J H W 2010, ' c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of Fc alpha RI and FcR gamma-chain ', European Journal of Immunology, vol. 40, no. 7, pp. 2035-2040 . https://doi.org/10.1002/eji.200939985
European Journal of Immunology, 40, 2035-40

Contains fulltext : 87311.pdf (Publisher’s version ) (Closed access) The receptor for IgA, FcalphaRI or CD89, is expressed on myeloid cells and can trigger phagocytosis, tumor cell lysis, and release of inflammatory mediators. These functions criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524270d9e0657bbc691e55b8b70e0a41
https://doi.org/10.1002/eji.200939985

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