GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1

Autor: Dandan Ma, Wei Sun, Cuicui Fu, Kamran Nazmi, Enno C. I. Veerman, Richard T. Jaspers, Jan G. M. Bolscher, Floris J. Bikker, Gang Wu

Publikováno v: International Journal of Oral Science, Vol 14, Iss 1, Pp 1-15 (2022)

Abstract Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity. We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mito

Externí odkaz: https://doaj.org/article/b333107ddf454e5aa536f9fbfb97fb17

Antitumor activity of bovine lactoferrin and its derived peptides against HepG2 liver cancer cells and Jurkat leukemia cells

Autor: Izamar G. Arredondo-Beltrán, Diana A. Ramírez-Sánchez, Jesús R. Zazueta-García, Adrián Canizalez-Roman, Uriel A. Angulo-Zamudio, Jorge A. Velazquez-Roman, Jan G. M. Bolscher, Kamran Nazmi, Nidia León-Sicairos

Publikováno v: Arredondo-Beltrán, I G, Ramírez-Sánchez, D A, Zazueta-García, J R, Canizalez-Roman, A, Angulo-Zamudio, U A, Velazquez-Roman, J A, Bolscher, J G M, Nazmi, K & León-Sicairos, N 2023, ' Antitumor activity of bovine lactoferrin and its derived peptides against HepG2 liver cancer cells and Jurkat leukemia cells ', BioMetals, vol. 36, no. 3, pp. 639-655 . https://doi.org/10.1007/s10534-022-00484-4
BioMetals, 36(3), 639-655. Springer Netherlands

Liver cancer and leukemia are the fourth and first causes, respectively, of cancer death in children and adults worldwide. Moreover, cancer treatments, although beneficial, remain expensive, invasive, toxic, and affect the patient’s quality of life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304dd65926e23881b35b01ba491ac23d
https://doi.org/10.1007/s10534-022-00484-4

D-LL-31 enhances biofilm-eradicating effect of currently used antibiotics for chronic rhinosinusitis and its immunomodulatory activity on human lung epithelial cells.

Autor: Saharut Wongkaewkhiaw, Suwimol Taweechaisupapong, Sanguansak Thanaviratananich, Jan G M Bolscher, Kamran Nazmi, Chitchanok Anutrakunchai, Sorujsiri Chareonsudjai, Sakawrat Kanthawong

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0243315 (2020)

Chronic rhinosinusitis (CRS) is a chronic disease that involves long-term inflammation of the nasal cavity and paranasal sinuses. Bacterial biofilms present on the sinus mucosa of certain patients reportedly exhibit resistance against traditional ant

Externí odkaz: https://doaj.org/article/2b0bef926a104e93a8f43dfe22117f2f

Synergistic effects of LFchimera and antibiotic against planktonic and biofilm form of Aggregatibacter actinomycetemcomitans.

Autor: Marie Rossini Carmela T Lachica, Chitchanok Anutrakunchai, Saengsome Prajaneh, Kamran Nazmi, Jan G M Bolscher, Suwimol Taweechaisupapong

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0217205 (2019)

Adjunctive use of antibiotics in periodontal treatment have limitations and disadvantages including bacterial resistance. Antimicrobial peptides (AMPs) are potential new agents that can combat bacterial infection. In this study, antimicrobial activit

Externí odkaz: https://doaj.org/article/8873ceb8b3474614b6b8d9289f4173e9

Impact of nutritional stress on drug susceptibility and biofilm structures of Burkholderia pseudomallei and Burkholderia thailandensis grown in static and microfluidic systems.

Autor: Chitchanok Anutrakunchai, Jan G M Bolscher, Bastiaan P Krom, Sakawrat Kanthawong, Sorujsiri Chareonsudjai, Suwimol Taweechaisupapong

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194946 (2018)

Burkholderia pseudomallei is the causative agent of melioidosis and regarded as a bioterrorism threat. It can adapt to the nutrient-limited environment as the bacteria can survive in triple distilled water for 16 years. Moreover, B. pseudomallei exhi

Externí odkaz: https://doaj.org/article/bc45c458da314fb887b8951442ed2d11