Zobrazeno 1 - 10
of 763
pro vyhledávání: '"Jan G, Hengstler"'
Autor:
Annika Glotzbach, Katharina Rohlf, Anastasia Gonscharow, Simon Lüke, Özlem Demirci, Brigitte Begher-Tibbe, Nina Overbeck, Jörg Reinders, Cristina Cadenas, Jan G. Hengstler, Karolina Edlund, Rosemarie Marchan
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-20 (2024)
Abstract Background Despite progress understanding the mechanisms underlying tumor spread, metastasis remains a clinical challenge. We identified the choline-producing glycerophosphodiesterase, EDI3 and reported its association with metastasis-free s
Externí odkaz:
https://doaj.org/article/f5f898d38fee442c8efa7d5ee8240227
Autor:
Sebastian Burbano de Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 3, Pp 187-216 (2024)
Abstract Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated steatotic liver disease (MASLD) is gaining importance as the disease can develop
Externí odkaz:
https://doaj.org/article/3da48164f4ad45c9b893d493adac3081
Autor:
Thura Kadhum, Silvia Selinski, Meinolf Blaszkewicz, Jörg Reinders, Emanuel Roth, Frank Volkert, Daniel Ovsiannikov, Oliver Moormann, Holger Gerullis, Dimitri Barski, Thomas Otto, Svetlana Höhne, Jan G. Hengstler, Klaus Golka
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 867-879 (2023)
Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder canc
Externí odkaz:
https://doaj.org/article/84b2d27c9b95456eb35a270378795b24
Autor:
Anna Cherianidou, Franziska Kappenberg, Florian Seidel, Aviseka Acharya, Panagiota Papazoglou, Sureshkumar Perumal Srinivasan, Jürgen Hescheler, Luying Peng, Marcel Leist, Jan G. Hengstler, Jörg Rahnenführer, Agapios Sachinidis
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Summary Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, and time-consuming. Often, studies are not of human relevance because of species differences. In the present study, we recap
Externí odkaz:
https://doaj.org/article/3033166cf6ba47248dc4369924655b7f
Autor:
Seddik Hammad, Christoph Ogris, Amnah Othman, Pia Erdoesi, Wolfgang Schmidt-Heck, Ina Biermayer, Barbara Helm, Yan Gao, Weronika Piorońska, Christian H. Holland, Lorenza A. D’Alessandro, Carolina de la Torre, Carsten Sticht, Sherin Al Aoua, Fabian J. Theis, Heike Bantel, Matthias P. Ebert, Ursula Klingmüller, Jan G. Hengstler, Steven Dooley, Nikola S. Mueller
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-13 (2023)
Abstract The human liver has a remarkable capacity to regenerate and thus compensate over decades for fibrosis caused by toxic chemicals, drugs, alcohol, or malnutrition. To date, no protective mechanisms have been identified that help the liver tole
Externí odkaz:
https://doaj.org/article/51b08471f4314fc5a23b5a9f8fd9aea5
Autor:
Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordström, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessica Hoppstädter, Ho-Ryun Chung, Philip Rosenstiel, Jan G. Hengstler, Jörn Walter, Marcel H. Schulz, Sonja M. Kessler, Alexandra K. Kiemer
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known
Externí odkaz:
https://doaj.org/article/08abcdc296d74786a777114970ddef43
Autor:
Wenfang Gui, Mikal Jacob Hole, Antonio Molinaro, Karolina Edlund, Kristin K. Jørgensen, Huan Su, Brigitte Begher-Tibbe, Nikolaus Gaßler, Carolin V. Schneider, Uthayakumar Muthukumarasamy, Antje Mohs, Lijun Liao, Julius Jaeger, Christian J. Mertens, Ina Bergheim, Till Strowig, Jan G. Hengstler, Johannes R. Hov, Hanns-Ulrich Marschall, Christian Trautwein, Kai Markus Schneider
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (
Externí odkaz:
https://doaj.org/article/822db6e3defc4196a740ad1cdce3eff7
Autor:
Rebekka Fendt, Ahmed Ghallab, Maiju Myllys, Ute Hofmann, Reham Hassan, Zaynab Hobloss, Daniela González, Lisa Brackhagen, Rosemarie Marchan, Karolina Edlund, Abdel-Latif Seddek, Noha Abdelmageed, Lars M. Blank, Jan-Frederik Schlender, Christian H. Holland, Jan G. Hengstler, Lars Kuepfer
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult.Methods: Cirrhosis in mice was induced by repeated treatment with carb
Externí odkaz:
https://doaj.org/article/a00c54ea3cb643a68996f363a731a079
Autor:
Johannes C. S. Zang, Caroline May, Birte Hellwig, Dirk Moser, Jan G. Hengstler, Steve Cole, Markus Heinrichs, Jörg Rahnenführer, Katrin Marcus, Robert Kumsta
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms underlying these effects, research so far focused on alterations of DNA methylation or shifts in tran
Externí odkaz:
https://doaj.org/article/045d62f33b014668ab660005e4e5b3ef
Autor:
Magdalena Keller, Katharina Rohlf, Annika Glotzbach, Gregor Leonhardt, Simon Lüke, Katharina Derksen, Özlem Demirci, Defne Göçener, Mohammad AlWahsh, Jörg Lambert, Cecilia Lindskog, Marcus Schmidt, Walburgis Brenner, Matthias Baumann, Eldar Zent, Mia-Lisa Zischinsky, Birte Hellwig, Katrin Madjar, Jörg Rahnenführer, Nina Overbeck, Jörg Reinders, Cristina Cadenas, Jan G. Hengstler, Karolina Edlund, Rosemarie Marchan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Background Intrinsic or acquired resistance to HER2-targeted therapy is often a problem when small molecule tyrosine kinase inhibitors or antibodies are used to treat patients with HER2 positive breast cancer. Therefore, the identification o
Externí odkaz:
https://doaj.org/article/3ce2fcec0f4f49f29458097699d65efb