Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jan Fredrik, Simons"'
Autor:
Rena A. Mizrahi, Wendy Y. Lin, Ashley Gras, Ariel R. Niedecken, Ellen K. Wagner, Sheila M. Keating, Nikita Ikon, Vishal A. Manickam, Michael A. Asensio, Jackson Leong, Angelica V. Medina-Cucurella, Emily Benzie, Kyle P. Carter, Yao Chiang, Robert C. Edgar, Renee Leong, Yoong Wearn Lim, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Dirk Büscher, Jose Vicente Terencio, Clara Di Germanio, Steven M. Chamow, Charles Olson, Paula A. Pino, Jun-Gyu Park, Amberlee Hicks, Chengjin Ye, Andreu Garcia-Vilanova, Luis Martinez-Sobrido, Jordi B. Torrelles, David S. Johnson, Adam S. Adler
Publikováno v:
Pathogens, Vol 11, Iss 7, p 806 (2022)
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. This is especially important where multi-epitope neutral
Externí odkaz:
https://doaj.org/article/30fbcf61da8b46ddab93ba7e247ee57f
Autor:
Jan Fredrik Simons, Yoong Wearn Lim, Kyle P. Carter, Ellen K. Wagner, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated an
Externí odkaz:
https://doaj.org/article/ac6112ed99b44416933c0b907771131b
Autor:
Nicholas P Wayham, Ariel R Niedecken, Jan Fredrik Simons, Yao Y Chiang, Angélica V Medina-Cucurella, Rena A Mizrahi, Ellen K Wagner, Ashley Gras, Ilana Segal, Peyton Witte, Alexis Enstrom, Aristea Bountouvas, Sabrina M Nelson, Tess Weinberger, David Tan, Michael A Asensio, Alagu Subramanian, Yoong Wearn Lim, Adam S Adler, Sheila M Keating
Publikováno v:
The Journal of Infectious Diseases.
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) possess mutations that prevent antibody therapeutics from maintaining antiviral binding and neutralizing efficacy. Monoclonal antibodies (mAbs) shown to neutralize Wuha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2bfb36483accb547c694e3d560f93c3
https://doi.org/10.1093/infdis/jiad102
https://doi.org/10.1093/infdis/jiad102
Autor:
Christine V.F. Carrington, Steven M Chamow, Adam S. Adler, Matthew Adams, Sheila M. Keating, Emma Pearce, Ashley Gras, Robert C. Edgar, Charles Olson, Dirk Büscher, Jasmeen Saini, Kyle P Carter, Ariel R Niedecken, Heather E. Lynch, Rachel Mosher, Ellen K. Wagner, Vishal A. Manickam, Renee Leong, Bishal K. Gautam, Jan Fredrik Simons, Marcus O. Muench, Matthew J. Spindler, Jose Vicente Terencio, LaRee Tracy, Brendan Tinsley, Thomas H. Oguin, David S. Johnson, Yao Chiang, Nicholas Wayham, Everett Meyer, Rena A. Mizrahi, Anushka T. Ramjag, Carl A. Ross, Carina Vingsbo Lundberg, David Goldblatt, Matthew J Walch, Yoong Wearn Lim, Jackson Leong, Michael A. Asensio, Lucy Roalfe, Robert Jeanfreau, Emily Benzie, Christopher R. Bartley, Graham Simmons, Hayley Richardson, Bryan Monroe, Angélica V Medina-Cucurella, Kacy Stadtmiller
Publikováno v:
Nature biotechnology
Plasma-derived polyclonal antibody therapeutics, such as intravenous immunoglobulin, have multiple drawbacks, including low potency, impurities, insufficient supply, and batch-to-batch variation. Here we describe a microfluidics and molecular genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8917bb26c73ba55ef1640d50a52b47
http://europepmc.org/articles/PMC8355030
http://europepmc.org/articles/PMC8355030
Autor:
Angélica V. Medina-Cucurella, Rena A. Mizrahi, Michael A. Asensio, Robert C. Edgar, Jackson Leong, Renee Leong, Yoong Wearn Lim, Ayla Nelson, Ariel R. Niedecken, Jan Fredrik Simons, Matthew J. Spindler, Kacy Stadtmiller, Nicholas Wayham, Adam S. Adler, David S. Johnson
Publikováno v:
Antibodies, Vol 8, Iss 1, p 17 (2019)
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (
Externí odkaz:
https://doaj.org/article/4a06d9d0e77d4bfe97384b6e3af1b455
Autor:
Everett Meyer, David S. Johnson, Lucy Roalfe, Rena A. Mizrahi, Terencio Jv, David Goldblatt, Ariel R Niedecken, Marcus O. Muench, Jeanfreau R, Olson C, Heather E. Lynch, Matthew J. Spindler, Ashley Gras, Thomas H. Oguin, Emily Benzie, Graham Simmons, Kyle P Carter, Robert C. Edgar, Adam S. Adler, Emma Pearce, Yoong Wearn Lim, Kacy Stadtmiller, Jan Fredrik Simons, Hayley Richardson, Bishal K. Gautam, Renee Leong, Ellen K. Wagner, Angélica V Medina-Cucurella, Adams Ms, Chiang Y, Michael A. Asensio, Anushka T. Ramjag, LaRee Tracy, Brendan Tinsley, Jasmeen Saini, Jackson Leong, Christine V.F. Carrington, Sheila M. Keating, Monroe B, Carina Vingsbo Lundberg, Vishal A. Manickam, Chamow Sm, Büscher D, Nicholas Wayham
Plasma-derived polyclonal antibodies are polyvalent drugs used for many important clinical indications that require modulation of multiple drug targets simultaneously, including emerging infectious disease and transplantation. However, plasma-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b038c76143f6982660b22067931792
https://doi.org/10.1101/2020.08.05.232975
https://doi.org/10.1101/2020.08.05.232975
Autor:
Kyle P Carter, Jan Fredrik Simons, Adam S. Adler, Ellen K. Wagner, Nicholas Wayham, David S. Johnson, Yoong Wearn Lim
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity. Currently there are no universally accepted protocols for generation of variegated an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57953245e7061c5158852c2dc690a6fa
https://pubmed.ncbi.nlm.nih.gov/32744131
https://pubmed.ncbi.nlm.nih.gov/32744131
Autor:
Adam S. Adler, Kacy Stadtmiller, Angélica V Medina-Cucurella, Ayla Nelson, Jan Fredrik Simons, Robert C. Edgar, Matthew J. Spindler, Renee Leong, Ariel R Niedecken, Rena A. Mizrahi, David S. Johnson, Michael A. Asensio, Nicholas Wayham, Yoong Wearn Lim, Jackson Leong
Publikováno v:
Antibodies
Volume 8
Issue 1
Antibodies, Vol 8, Iss 1, p 17 (2019)
Volume 8
Issue 1
Antibodies, Vol 8, Iss 1, p 17 (2019)
To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77227bbd61c52724ca84e5ae2ab9915e
Autor:
Michael S. Braverman, Richard M. Novak, Michael J. Kozal, Jan Fredrik Simons, Birgitte B. Simen, John D. Baxter, Brian Desany, Rodger D. MacArthur, Chunli Huang, Christine Lubeski, Jonathan M. Rothberg, Katherine Huppler Hullsiek, Michael Egholm, Gregory S. Turenchalk
Publikováno v:
Journal of Infectious Diseases. 199:693-701
Background. Minor (i.e.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269ae8ced7ed9c49cd4bc97851b9bdcf
https://doi.org/10.1086/596736
https://doi.org/10.1086/596736
Autor:
Fengtang Yang, Jason P. Affourtit, Michael Egholm, Brian C. Godwin, Nigel P. Carter, Bruce E. Taillon, Philip M. Kim, Michael Snyder, Andrea Tanzer, Alexander E. Urban, A. C. Eugenia Saunders, Jan Fredrik Simons, Zhoutao Chen, Sherman M. Weissman, Matthew E. Hurles, Lei Du, Jianxiang Chi, Fabian Grubert, Nicholas Carriero, Jan O. Korbel, Mark Gerstein, Timothy T. Harkins, Dean Palejev
Publikováno v:
Science. 318:420-426
Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inversions, and complex combinations of rearrangements. We introduce high-throughput and massive paired-end mapping (PEM), a large-scale geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201178d3f3fcf1c12a1003a83d4b5c81
https://doi.org/10.1126/science.1149504
https://doi.org/10.1126/science.1149504