Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Jan Frayne"'
Autor:
Telma Ventura, Antonella Fidanza, Marieangela C. Wilson, Daniel C. J. Ferguson, Phillip A. Lewis, Alisha May, Helen Taylor, Michael P. Rimmer, Christopher D. Gregory, Jan Frayne, Lesley M. Forrester
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast numbers of red blood cells (RBCs) that are produced throughout life. Their location within the bone marrow makes it difficult to
Externí odkaz:
https://doaj.org/article/efb4c16f8d8e4e2885212d3119f67a99
Autor:
Deborah E. Daniels, Ivan Ferrer-Vicens, Joseph Hawksworth, Tatyana N. Andrienko, Elizabeth M. Finnie, Natalie S. Bretherton, Daniel C. J. Ferguson, A. Sofia. F. Oliveira, Jenn-Yeu A. Szeto, Marieangela C. Wilson, John N. Brewin, Jan Frayne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract β-thalassemia is a prevalent genetic disorder causing severe anemia due to defective erythropoiesis, with few treatment options. Studying the underlying molecular defects is impeded by paucity of suitable patient material. In this study we
Externí odkaz:
https://doaj.org/article/9939683767224f40b2a842f9297fb596
Autor:
Deborah E. Daniels, Damien J. Downes, Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Belinda K. Singleton, Marieangela C. Wilson, Kongtana Trakarnsanga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne
Publikováno v:
Haematologica, Vol 109, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/4d782518f626402dbd7d20dbf0bff7ad
Autor:
Chartsiam Tipgomut, Archrob Khuhapinant, Marieangela C. Wilson, Saiphon Poldee, Kate J. Heesom, Chanatip Metheetrairut, Orapan Sripichai, Chalermchai Mitrpant, Jan Frayne, Kongtana Trakarnsanga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Polycythaemia vera (PV) is a haematological disorder caused by an overproduction of erythroid cells. To date, the molecular mechanisms involved in the disease pathogenesis are still ambiguous. This study aims to identify aberrantly expressed
Externí odkaz:
https://doaj.org/article/5b15d64123864b8b8feb2015fea7d143
Autor:
Joschka Heil, Victor Olsavszky, Katrin Busch, Kay Klapproth, Carolina de la Torre, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Hiltrud Schönhaber, Johanna Zierow, Manuel Winkler, Christian David Schmid, Theresa Staniczek, Deborah E. Daniels, Jan Frayne, Georgia Metzgeroth, Daniel Nowak, Sven Schneider, Michael Neumaier, Vanessa Weyer, Christoph Groden, Hermann-Josef Gröne, Karsten Richter, Carolin Mogler, Makoto Mark Taketo, Kai Schledzewski, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Koch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre dri
Externí odkaz:
https://doaj.org/article/807900d34c274dcfa83939c240d17adf
Autor:
Deborah E. Daniels, Daniel C.J. Ferguson, Rebecca E. Griffiths, Kongtana Trakarnsanga, Nicola Cogan, Katherine A. MacInnes, Kathryn E. Mordue, Tatyana Andrienko, Ivan Ferrer-Vicens, Daniel Ramos Jiménez, Phillip A. Lewis, Marieangela C. Wilson, Maurice A. Canham, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 26-39 (2021)
Developing robust methodology for the sustainable production of red blood cells in vitro is essential for providing an alternative source of clinical-quality blood, particularly for individuals with rare blood group phenotypes. Immortalized erythroid
Externí odkaz:
https://doaj.org/article/1be556ed511b484ca9104a2782e6751a
Autor:
Marjolein Meinders, Debbie Shoemark, Johannes G.G. Dobbe, Geert J. Streekstra, Jan Frayne, Ashley M. Toye
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 822-830 (2020)
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal metabolic disorder caused by thymidine phosphorylase (TP) deficiency. Successful therapeutic interventions for this disease rely on a means for efficient and long-lasti
Externí odkaz:
https://doaj.org/article/3949e15aadbd4bcb971876223c0d2b24
Autor:
Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Here, the authors show that reticulocytes derived from immortalized erythroblasts support invasion and development of Plasmodium falciparum and use CRISPR-mediated gene knockout and complementation of an invasion receptor to demonstrate utility of th
Externí odkaz:
https://doaj.org/article/cb05acb78a2c45d997fced9f3abed603
Autor:
Kongtana Trakarnsanga, Daniel Ferguson, Deborah E. Daniels, Rebecca E. Griffiths, Marieangela C. Wilson, Kathryn E. Mordue, Abi Gartner, Tatyana N. Andrienko, Annabel Calvert, Alison Condie, Angela McCahill, Joanne C. Mountford, Ashley M. Toye, David J. Anstee, Jan Frayne
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2019)
Abstract Background Pluripotent stem cells are attractive progenitor cells for the generation of erythroid cells in vitro as have expansive proliferative potential. However, although embryonic (ESC) and induced pluripotent (iPSC) stem cells can be in
Externí odkaz:
https://doaj.org/article/ab66fdf60c4c4d08878afa9f330cc664
Autor:
Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne
Publikováno v:
Haematologica, Vol 106, Iss 11 (2020)
Human ZNF648 is a novel poly C-terminal C2H2 zinc finger (ZnF) protein identified amongst the most dysregulated proteins in erythroid cells differentiated from induced pluripotent stem cells. Its nuclear localization and structure indicate it is like
Externí odkaz:
https://doaj.org/article/74d92bd41183494184a640381d6306d2