The transcription factor Atf1 lowers the transition barrier for nucleosome-mediated establishment of heterochromatin

Autor: Jan Fabio Nickels, Maria Eduarda Della-Rosa, Iñigo Miguelez Goyeneche, Sebastian Jespersen Charlton, Kim Sneppen, Genevieve Thon

Publikováno v: Cell Reports, Vol 39, Iss 7, Pp 110828- (2022)

Summary: Transcription factors can exert opposite effects depending on the chromosomal context. The fission yeast transcription factor Atf1 both activates numerous genes in response to stresses and mediates heterochromatic gene silencing in the matin

Externí odkaz: https://doaj.org/article/83af020f44bd438d961a62ac8d8fa949

Establishment of heterochromatin in domain-size-dependent bursts

Autor: Sif Christine Lykke Hougaard, Geneviève Thon, Jan Fabio Nickels, Ala Trusina, Amanda Møller Mortensen, Kim Sneppen, Sebastian Jespersen Charlton, Ashleigh Katrine Edwards

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Nickels, J F, Edwards, A K, Charlton, S J, Mortensen, A M, Hougaard, S C L, Trusina, A, Sneppen, K & Thon, G 2021, ' Establishment of heterochromatin in domain-size-dependent bursts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 15, e2022887118 . https://doi.org/10.1073/pnas.2022887118

Significance How repressive heterochromatic states propagate along chromosomes and are subsequently maintained for many cell divisions remain important unanswered questions in biology. Combining mathematical modeling and single-cell measurements, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad7e03626182a75a67a0330564532a2
https://doi.org/10.1073/pnas.2022887118