Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jan FLECKNER"'
Autor:
Paul Horn, Jenny Norlin, Kasper Almholt, Birgitte M Viuff, Elisabeth D Galsgaard, Andreas Hald, Franziska Zosel, Helle Demuth, Svend Poulsen, Peder L Norby, Morten G Rasch, Mogens Vyberg, Jan Fleckner, Mikkel Parsberg Werge, Lise Lotte Gluud, Marco R Rink, Emma Shepherd, Ellie Northall, Patricia F Lalor, Chris J Weston, Morten Fog-Tonnesen, Philip N Newsome
Publikováno v:
eLife, Vol 13 (2024)
Gremlin-1 has been implicated in liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) via inhibition of bone morphogenetic protein (BMP) signalling and has thereby been identified as a potential therapeutic target. Using rat in v
Externí odkaz:
https://doaj.org/article/26db31e3cfc948118f0e0cdf01eb4818
Autor:
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new
Externí odkaz:
https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677
Autor:
Klaus Stensgaard Frederiksen, Erik Max Wulff, Per Sauerberg, John Patrick Mogensen, Lone Jeppesen, Jan Fleckner
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 3, Pp 592-601 (2004)
Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug class of fibrates. In the present study, the molecular and physio
Externí odkaz:
https://doaj.org/article/f9cda664495647759e9b603ea7ec10d0
Autor:
Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002505 (2012)
Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abd
Externí odkaz:
https://doaj.org/article/48c00fdd38354c18b5237e49bea1cf97
Autor:
Mattias Rantalainen, Blanca M Herrera, George Nicholson, Rory Bowden, Quin F Wills, Josine L Min, Matt J Neville, Amy Barrett, Maxine Allen, Nigel W Rayner, Jan Fleckner, Mark I McCarthy, Krina T Zondervan, Fredrik Karpe, Chris C Holmes, Cecilia M Lindgren
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27338 (2011)
To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miR
Externí odkaz:
https://doaj.org/article/d2cb4510af2f40deb759996a4e17e510
Autor:
Hila Milo-Rasouly, Sophia R. Cameron-Christie, Vimla Aggarwal, Carolina Haefliger, Byum Hee Kil, Adam Platt, Brett Copeland, Andrew S. Bomback, Wan Yee Lam, Natalie S Uy, Simone Sanna-Cherchi, Junying Zhang, Rachel Reingold, Zhong Ren, Stacy Piva, Adele Mitrotti, David J. Cohen, Debanjana Chatterjee, Ruth March, Emily E. Groopman, Maddalena Marasa, Drew Bradbury, Sumit Mohan, Michael DiVecchia, David Goldstein, Shumyle Alam, Colin D. Malone, Jordan G. Nestor, Jan Fleckner, Chunhua Weng, Gerald B. Appel, Yifu Li, Priya Krithivasan, Russell J. Crew, Neha Dagaonkar, Olivia Balderes, Karla Mehl, David Fasel, Holly J. Snyder, Maya K. Rao, Joshua Bridgers, Geoffrey K. Dube, Krzysztof Kiryluk, Pietro A. Canetta, Bengt Fellström, Ali G. Gharavi, Jai Radhakrishnan, Wooin Ahn, Caroline Mebane, Slavé Petrovski, Xueru Mu, Sitharthan Kamalakaran
Publikováno v:
New England Journal of Medicine. 380:142-151
BACKGROUND: Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e8c8b3cbd348e504a27d334077dccd
https://doi.org/10.1056/nejmoa1806891
https://doi.org/10.1056/nejmoa1806891
Autor:
R. Scott Heller, Klaus Stensgaard Frederiksen, Thomas Lindebo Holm, Jan Fleckner, Claus Heiner Bang-Berthelsen, Peter Helding Kvist, Lasse Folkersen, Malene Jackerott, Rolf Søkilde, Lotte Simonsen, Charles Pyke, Mogens Vilien, Anders Heding, Flemming Pociot, Lotte Bjerre Knudsen
Publikováno v:
Inflammatory Bowel Diseases. 22:2078-2097
BACKGROUND: Beneficial roles for glucagon-like peptide 1 (GLP-1)/GLP-1R signaling have recently been described in diseases, where low-grade inflammation is a common phenomenon. We investigated the effects of GLP-1 in Brunner's glands and duodenum wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af561f78ed063845eaffbf06da49465
https://doi.org/10.1097/mib.0000000000000847
https://doi.org/10.1097/mib.0000000000000847
Autor:
Valentina, Manfè1,2 vlmn@novonordisk.com, Jan, Fleckner1, Peder, Nørby Lisby1, Zhang Bo2, Dai Hongjie2, Pernille, Keller1
Publikováno v:
BMC Biotechnology. Aug2015, Vol. 15 Issue 1, p1-6. 6p.
Autor:
Jan Fleckner, Bengt Fellström, Dimitrios Vitsios, Ruth March, Sophia R. Cameron-Christie, Simone Sanna-Cherchi, Slavé Petrovski, Ali G. Gharavi, Sitharthan Kamalakaran, Charles J. Wolock, Gundula Povysil, Krzysztof Kiryluk, Adam Platt, Andrew S. Allen, Emily E. Groopman, Yifu Li, David Goldstein, Mengqi Zhang, Sahar Gelfman, Carolina Haefliger, Maddalena Marasa
Publikováno v:
J Am Soc Nephrol
Background Studies have identified many common genetic associations that influence renal function and all-cause CKD, but these explain only a small fraction of variance in these traits. The contribution of rare variants has not been systematically ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44149e6d17d07bde7da2033f6c853965
https://pubmed.ncbi.nlm.nih.gov/31085678
https://pubmed.ncbi.nlm.nih.gov/31085678
Autor:
Nathan Denton, Josine L. Min, Philippe Valet, Christopher Holmes, Mark I. McCarthy, Krina T. Zondervan, Katherine E. Pinnick, Keith N. Frayn, Fredrik Karpe, Jan Fleckner, George Nicholson, Konstantinos N. Manolopoulos, S. McQuaid
Upper- and lower-body fat depots exhibit opposing associations with obesity-related metabolic disease. We defined the relationship between DEXA-quantified fat depots and diabetes/cardiovascular risk factors in a healthy population-based cohort (n = 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e2a21e207bb4c9713faee8bff36029
https://doi.org/10.2337/db14-0385
https://doi.org/10.2337/db14-0385
