Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jan F. Klinker"'
Autor:
Roland Seifert, Jan F. Klinker
Publikováno v:
Biochemical and Biophysical Research Communications. 262:341-345
Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5′-triphosphates inhibited transducin-catalyzed GTP hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752c0518d98d5bf9f991a683ccc026b6
https://doi.org/10.1006/bbrc.1999.1203
https://doi.org/10.1006/bbrc.1999.1203
Publikováno v:
Neuroscience Letters. 213:25-28
Effects of ethanol on signal transduction in neuronal membranes are supposed to occur by the interaction with heterotrimeric guanine nucleotide-binding proteins (G-proteins). Several substances affect signal transduction by activation of G-proteins d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b8890b942c998f1586a11330270b89
https://doi.org/10.1016/0304-3940(96)12816-0
https://doi.org/10.1016/0304-3940(96)12816-0
Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes
Publikováno v:
Biochemical Pharmacology. 51:217-223
The wasp venom, mastoparan (MP), is a direct activator of reconstituted pertussis toxin-sensitive G-proteins and of purified nucleoside diphosphate kinase (NDPK) [E.C. 2.6.4.6.]. In HL-60 membranes, MP activates high-affinity GTPase [E.C. 3.6.1.-] an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dc5aed96d6ac7ceb6e7fe1199951d43
https://doi.org/10.1016/0006-2952(95)02119-1
https://doi.org/10.1016/0006-2952(95)02119-1
Publikováno v:
Experimental Dermatology. 4:231-239
Studies from several laboratories have revealed that structurally diverse substances including the wasp venom, mastoparan (MP), activate purified regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins) in a receptor-independent man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62483b249117cd9ef08943619ce59e68
https://doi.org/10.1111/j.1600-0625.1995.tb00251.x
https://doi.org/10.1111/j.1600-0625.1995.tb00251.x
Autor:
W Schunack, Rainer Harhammer, Roland Seifert, A. Hagelüken, Lore Grünbaum, Bernd Nürnberg, Günter Schultz, Christian Leschke, Jan F. Klinker
Publikováno v:
Biochemical Pharmacology. 49:901-914
In dibutyryl cAMP-differentiated human leukemia (HL-60) cells, the potent histamine H1-receptor agonist, 2-(3-chlorophenyl)histamine, activates pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G-proteins) of the Gi-subfamily by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9f0ec6ce2d4ab43863ab4561b7306b
https://doi.org/10.1016/0006-2952(94)00514-m
https://doi.org/10.1016/0006-2952(94)00514-m
Autor:
Roland Seifert, Jan F. Klinker
Publikováno v:
Pharmazie in Unserer Zeit. 24:250-263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4005bd250fd9710fedafbba8f42643bb
https://doi.org/10.1002/pauz.19950240505
https://doi.org/10.1002/pauz.19950240505
Autor:
Roland Seifert, Jan F. Klinker
Publikováno v:
European journal of biochemistry. 261(1)
Known nucleoside diphosphate kinases (NDPKs) are oligomers of 17-23-kDa subunits and catalyze the reaction N1TP + N2DP --N1DP + N2TP via formation of a histidine-phosphorylated enzyme intermediate. NDPKs are involved in the activation of heterotrimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993e05fb7b034baac139ba7c10c0c1a2
https://pubmed.ncbi.nlm.nih.gov/10103035
https://pubmed.ncbi.nlm.nih.gov/10103035
Autor:
Roland Seifert, Jan F. Klinker
Publikováno v:
Biochemical pharmacology. 54(5)
G-proteins mediate signal transfer from receptors to effector systems. In their guanosine 5'-triphosphate (GTP)-bound form, G-protein alpha-subunits activate effector systems. Termination of G-protein activation is achieved by the high-affinity GTPas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc9c27a7315598dcbd6c64498cf0d03
https://pubmed.ncbi.nlm.nih.gov/9337071
https://pubmed.ncbi.nlm.nih.gov/9337071
Publikováno v:
Biochemical pharmacology. 53(11)
Naturally occurring beta-carbolines are lipophilic compounds which show psychotropic and physiological effects in mammals. They bind to distinct high-affinity binding sites in various mammalian tissues. However, the mechanism by which the beta-carbol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a97b2b2ecb0fa2fe3843052780c6bd5
https://pubmed.ncbi.nlm.nih.gov/9264314
https://pubmed.ncbi.nlm.nih.gov/9264314
Publikováno v:
General pharmacology. 27(1)
1. 1. HL-60 human leukemia cells are a widely employed model system for the analysis of signal transduction processes mediated via regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). HL-60 promyelocytes are pluripotent and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92e1f9c5f58e9c79b690bc9f3e7582e
https://pubmed.ncbi.nlm.nih.gov/8742493
https://pubmed.ncbi.nlm.nih.gov/8742493