Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jan F Jikeli"'
Autor:
Shatanik Mukherjee, Vera Jansen, Jan F Jikeli, Hussein Hamzeh, Luis Alvarez, Marco Dombrowski, Melanie Balbach, Timo Strünker, Reinhard Seifert, U Benjamin Kaupp, Dagmar Wachten
Publikováno v:
eLife, Vol 5 (2016)
The cellular messenger cAMP regulates multiple cellular functions, including signaling in cilia and flagella. The cAMP dynamics in these subcellular compartments are ill-defined. We introduce a novel FRET-based cAMP biosensor with nanomolar sensitivi
Externí odkaz:
https://doaj.org/article/aaf3386b6d7b47d1b78fa1f71fd7c228
Autor:
Roland T Ullrich, Jan F Jikeli, Michael Diedenhofen, Philipp Böhm-Sturm, Maike Unruh, Stefan Vollmar, Mathias Hoehn
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19592 (2011)
PURPOSE: Inhibition of angiogenesis has shown clinical success in patients with cancer. Thus, imaging approaches that allow for the identification of angiogenic tumors and the detection of response to anti-angiogenic treatment are of high clinical re
Externí odkaz:
https://doaj.org/article/a318e769f8234652a6a23ed6dc7bd567
Autor:
Jan N. Hansen, An Gong, Dagmar Wachten, René Pascal, Alex Turpin, Jan F. Jikeli, U. Benjamin Kaupp, Luis Alvarez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Multifocal imaging suffers from a number of limitations. Here the authors report an open-source 3D reconstruction algorithm to enable label-free tracking of spherical and filamentous structures which they use to characterise fluid flow and flagellar
Externí odkaz:
https://doaj.org/article/6077319b1f614bdbad31c204d6adbb5d
Autor:
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper. However, the physiologi
Externí odkaz:
https://doaj.org/article/87d6e04ca4ce4b2cb1e990ab3f22a423
Autor:
Guglielmo Saggiorato, Luis Alvarez, Jan F. Jikeli, U. Benjamin Kaupp, Gerhard Gompper, Jens Elgeti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The mechanism allowing sperm to steer is not fully understood. The authors find that superposition of two harmonic waves breaks the flagellar beat symmetry temporally rather than spatially, and that this mechanism is enhanced by the sexual hormone pr
Externí odkaz:
https://doaj.org/article/d97db4ce226d4bffbf1df60dbd803fb0
Publikováno v:
Cells, Vol 8, Iss 1, p 10 (2018)
Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the
Externí odkaz:
https://doaj.org/article/cd39aa660f8b4e30b9ac3a24869363ef
Autor:
Pia Neugebauer, Harvey M. Florman, Luca Jovine, Christian Schiffer, Hussein Hamzeh, Melanie Balbach, Jan F. Jikeli, U. Benjamin Kaupp, Christian Trötschel, Timo Strünker, Jan N. Hansen, Dagmar Wachten, Christoph Brenker, Ling Han
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper. However, the physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176e20108cb7bf6b7ab7e6da20a8acd
https://www.frontiersin.org/article/10.3389/fcell.2020.572735/full
https://www.frontiersin.org/article/10.3389/fcell.2020.572735/full
Autor:
Lea Wobig, Reinhard Seifert, Heinz G. Körschen, Sylvia Fechner, Thomas K. Berger, U. Benjamin Kaupp, Jan F. Jikeli, Regina Feederle, Wolfgang Bönigk, Christian Trötschel, Thérèse Wolfenstetter
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We discovered a subfamily of voltage-gated ion channels, called HCN-like channels, consisting of two members, HCNL1 and HCNL2. In contrast to classic pacemaker HCN channels in the heart and brain, HCNL1 conducts protons rather than potas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d4f4383f458393d4a05ff6920d390a
https://hdl.handle.net/21.11116/0000-0006-7C87-721.11116/0000-0007-640F-9
https://hdl.handle.net/21.11116/0000-0006-7C87-721.11116/0000-0007-640F-9
Autor:
Dagmar Wachten, An Gong, U. Benjamin Kaupp, Jan N. Hansen, Luis Alvarez, Jan F. Jikeli, René Pascal, Alex Turpin
Many biological processes happen on a nano-to millimeter scale and within milliseconds. Established methods such as confocal microscopy are suitable for precise 3D recordings but lack the temporal or spatial resolution to resolve fast 3D processes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7142a42d4c0f45b46b136e4a51e0388
https://doi.org/10.1101/2020.05.16.099390
https://doi.org/10.1101/2020.05.16.099390
Publikováno v:
Current Opinion in Biotechnology
Highlights - Optogenetics controls cyclic nucleotide signaling with spatio-temporal resolution. - Genetic-engineering creates new tools by combining photosensory and effector domains. - Optogenetic control of cyclic nucleotide signaling controls phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fc9505850b074c81e40c76181953b9
https://doi.org/10.1016/j.copbio.2017.02.014
https://doi.org/10.1016/j.copbio.2017.02.014