Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Jan Eric, Turner"'
Autor:
Jonas Engesser, Robin Khatri, Darius P. Schaub, Yu Zhao, Hans-Joachim Paust, Zeba Sultana, Nariaki Asada, Jan-Hendrik Riedel, Varshi Sivayoganathan, Anett Peters, Anna Kaffke, Saskia-Larissa Jauch-Speer, Thiago Goldbeck-Strieder, Victor G. Puelles, Ulrich O. Wenzel, Oliver M. Steinmetz, Elion Hoxha, Jan-Eric Turner, Hans-Willi Mittrücker, Thorsten Wiech, Tobias B. Huber, Stefan Bonn, Christian F. Krebs, Ulf Panzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN r
Externí odkaz:
https://doaj.org/article/287d8b69dd7e4d95bc28f18d29e2859c
Autor:
Ann-Christin Gnirck, Marie-Sophie Philipp, Alex Waterhölter, Malte Wunderlich, Nikhat Shaikh, Virginia Adamiak, Lena Henneken, Tobias Kautz, Tingting Xiong, Daniela Klaus, Pascal Tomczyk, Mohamad M. Al-Bahra, Dirk Menche, Mark Walkenhorst, Olivier Lantz, Anne Willing, Manuel A. Friese, Tobias B. Huber, Christian F. Krebs, Ulf Panzer, Christian Kurts, Jan-Eric Turner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory diseases of barrier organs, but so far, their role in kidney disease is unclear. Here we report that MAIT cells that recognize their prototypical ligand
Externí odkaz:
https://doaj.org/article/ea197fd8a59e40e69a85f91fdcdab807
Autor:
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M. Tomas, Elion Hoxha, Ulrich O. Wenzel, Tobias B. Huber, Thorsten Wiech, Jan-Eric Turner, Christian F. Krebs, Ulf Panzer
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Glucocorticoids remain a cornerstone of therapeutic regimes for autoimmune and chronic inflammatory diseases — for example, in different forms of crescentic glomerulonephritis — because of their rapid antiinflammatory effects, low cost, and wide
Externí odkaz:
https://doaj.org/article/6443c52a90ff43ecadb3bda903f06ac0
Autor:
Patricia Bartsch, Christoph Kilian, Malte Hellmig, Hans-Joachim Paust, Alina Borchers, Amirrtavarshni Sivayoganathan, Leon Enk, Yu Zhao, Nikhat Shaikh, Henning Büttner, Milagros N Wong, Victor G Puelles, Thorsten Wiech, Richard Flavell, Tobias B Huber, Jan-Eric Turner, Stefan Bonn, Samuel Huber, Nicola Gagliani, Hans-Willi Mittrücker, Holger Rohde, Ulf Panzer, Christian F Krebs
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010430 (2022)
Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis. In part
Externí odkaz:
https://doaj.org/article/380fd4269d2449729d87e44af873b2c2
Autor:
Jana Meiners, Martina Reitz, Nikolas Rüdiger, Jan-Eric Turner, Lennart Heepmann, Lena Rudolf, Wiebke Hartmann, Henry J McSorley, Minka Breloer
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009121 (2020)
Parasitic helminths are sensed by the immune system via tissue-derived alarmins that promote the initiation of the appropriate type 2 immune responses. Here we establish the nuclear alarmin cytokine IL-33 as a non-redundant trigger of specifically IL
Externí odkaz:
https://doaj.org/article/58d2186793aa4aa690c31ab0a26af445
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Since their identification as a separate family of leukocytes, Innate lymphoid cells (ILCs) have been shown to play crucial roles in immune-mediated diseases and repair mechanisms that restore tissue integrity after injury. ILCs mainly populate non-l
Externí odkaz:
https://doaj.org/article/918e586897194a48a7e874293969c189
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells are a specialized population of innate lymphocytes that have a major effector function in local immune responses. While their immunological functions in many inflammatory diseases are well established, comparatively little i
Externí odkaz:
https://doaj.org/article/87ffc1ba848444afa5805cfc1609bdc4
Autor:
Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O. Wenzel, Oliver M. Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T. Lindenmeyer, Elion Hoxha, Rolf A. K. Stahl, Tobias B. Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F. Krebs, Ulf Panzer
Publikováno v:
Science Translational Medicine. 15
GM-CSF in glomerulonephritis Despite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al . characterized pathological immune cells in samp
Autor:
Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B. Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner
Publikováno v:
The Journal of Immunology. 208:1585-1594
Innate lymphoid cells (ILCs) that express NK cell receptors (NCRs) and the transcription factor T-bet populate nonlymphoid tissues and are crucial in immune responses against viral infections and malignancies. Recent studies highlighted the heterogen
Autor:
Jan-Hendrik Riedel, Alina Borchers, Nariaki Asada, Anett Peters, Tilman Schmidt, Ulf Panzer, Pauline Ginsberg, Hans-Joachim Paust, Samuel Huber, Tobias B. Huber, Christian Krebs, Nicola Gagliani, Ning Song, Richard A. Flavell, Anna Kaffke, Jonas Luebbe, Jan-Eric Turner, Lennart Robben, Penelope Pelzcar, Sonja Hiekmann, Christoph Kilian
Publikováno v:
J Am Soc Nephrol
BACKGROUND: IL-17A–producing CD4(+) T helper (T(H)17) cells play a critical role in autoimmune and chronic inflammatory diseases, such as crescentic GN. The proinflammatory effects of IL-17 are mediated by the activation of the IL-17RA/IL-17RC comp