Výsledky vyhledávání - "Jan E. M. Basten"

The Synthesis of Substituted Benzo[c]chromen-6-ones by a Suzuki Coupling and Lactonization Sequence Using Ionic Liquids – from Laboratory Scale to Multi-Kilogram Synthesis

Autor: B. Ter Horst, J. Bergwerff, T. Roeters, Jan E. M. Basten, R. Van der Eem, Gerardus Johannes Kemperman, D. Van de Goor

Publikováno v: European Journal of Organic Chemistry. 2006:3169-3174

A series of benzo[c]chromen-6-ones are prepared by a Suzuki coupling and lactonization sequence starting with 2-methoxyphenylboronic acids and methyl 2-bromobenzoate derivatives. The use of ionic liquids in this synthesis has been explored. It was fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9163f016ec9ae156bf7e389372d5c037
https://doi.org/10.1002/ejoc.200600188

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Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers

Autor: C.M. Dreef-Tromp, Jan E. M. Basten, C. A. A. Van Boeckel, M.A. Broekhoven, Petitou Maurice, T. G. Van Dinther

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:2081-2086

The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d678228099851aff9ec3a8f0eaf8ebfd
https://doi.org/10.1016/s0960-894x(98)00382-5

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Synthesis of a Pentasaccharide–Oligonucleotide Conjugate: A Novel Antithrombotic Agent

Autor: W. H. A. Kuijpers, Rogier C. Buijsman, Constant A. A. van Boeckel, Jan E. M. Basten, E. Kuyl-Yeheskiely, Gijsbert A. van der Marel, Jacques H. van Boom

Publikováno v: Chemistry - A European Journal. 2:1572-1577

Derivatization of the octadecathymidylate derivative 18 (T18 ODN) containing a free amine function with sulfo-SIAB® gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f351bd06c2efd9f771990ea1df355d2f
https://doi.org/10.1002/chem.19960021216

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Synthesis of a dermatan sulphate-like hexasaccharide with a 'non-glycosamino' glycan structure

Autor: Petitou Maurice, N.M. Soijker, Guy Jaurand, C. A. A. Van Boeckel, P. Westerduin, Jan E. M. Basten

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:893-898

The synthesis of a “non-glycosamino” glycan counterpart (i.e. compound II ) of a naturally occuring dermatan sulphate hexasaccharide that binds with high affinity to heparin cofactor II is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41e64c0f9e01ad57a8c547fa3a733be2
https://doi.org/10.1016/s0960-894x(01)80258-4

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Biologically active heparin-like fragments with a 'non-glycosamino'glycan structure. Part 3 : o-alkylated-o-sulphated pentasaccharides

Autor: M. Petitoub, B. Olde-Hanter, P. Duchaussoy, Guy Jaurand, C. A. A. Van Boeckel, Jan E. M. Basten

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:905-910

The synthesis of analogues of biologically active heparin pentasaccharide fragments is reported. Replacement of N-sulphate by O-sulphate esters and introduction of various O-alkyl ethers resulted in biologically active “non-glycosamino“glycans. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4519e2b00bd5de57762daf9a8aa4f3dc
https://doi.org/10.1016/s0960-894x(00)80585-5

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Biologically active heparin-like fragments with a 'non-glycosamino'glycan structure. Part 2 : a tetra-o-methylated pentasaccharide with high affinity for antithrombin III

Autor: B. Olde-Hanter, M. Petitou, Jan E. M. Basten, C.A.A. van Boekel, G. Jauran

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:901-904

To simplify the preparation of biologically active oligosaccharide analogues of glycosaminoglycan fragments we describe an approach where N-sulphates are replaced by O-sulphates and free hydroxyls are substituted by methyl groups. In this communicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd68813ff235932aec8d3e4030796160
https://doi.org/10.1016/s0960-894x(00)80584-3

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