Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jan Duchek"'
Publikováno v:
Molecules, Vol 18, Iss 4, Pp 3906-3916 (2013)
The synthesis of stable guanofosfocin analogues has attracted considerable attention in the past 15 years. Several guanofosfocin analogues mimicking the three constitutional elements of mannose, ribose, and guanine were designed and synthesized. Inte
Externí odkaz:
https://doaj.org/article/0003f8e7fec8417fb7d165da8c45c5ed
Autor:
Christopher R. McCurdy, Robert D. Giacometti, D. Phillip Cox, Tomas Hudlicky, Stephen J. Cutler, Afeef S. Husni, Lukas Werner, Jan Duchek
Publikováno v:
The Journal of Organic Chemistry. 78:2914-2925
Heteroatom analogues of hydrocodone, in which the N-methyl functionality was replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c775afe8776af913dc3e7d1fe2fc6e9
https://doi.org/10.1021/jo3026753
https://doi.org/10.1021/jo3026753
Autor:
D. Phillip Cox, Mary Ann A. Endoma-Arias, David R. Adams, Tomas Hudlicky, Ales Machara, Martina Wernerova, Lukas Werner, Jan Duchek
Publikováno v:
Advanced Synthesis & Catalysis. 354:2706-2712
N-Oxides derived from oxycodone and O-acyloxymorphone were treated with the Burgess reagent to provide the corresponding oxazolidines in excellent yields. Oxazolidines derived from O-acyloxymorphone were further hydrolyzed to noroxymorphone, whose al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a27c8701919e9cc0e743303f2c47cb
https://doi.org/10.1002/adsc.201200676
https://doi.org/10.1002/adsc.201200676
Autor:
Jan Duchek, Andrea Vasella
Publikováno v:
Helvetica Chimica Acta. 94:977-986
Heating ortho-nitro-anilides 1–3 and 2-methyl-N-(3-nitropyridin-2-yl)propanamide (5) with 4 equiv. of a phosphine led to the 2-substituted benzimidazoles 6–8 and to the imidazo[4,5-b]pyridine 10, respectively, in yields between 45 and 85%. Heatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14d8b5b705fc12429394aa3afa28743c
https://doi.org/10.1002/hlca.201100123
https://doi.org/10.1002/hlca.201100123
Publikováno v:
Chemical Reviews. 111:4223-4258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba1d6435b6e056e65a53031dc49f25d
https://doi.org/10.1021/cr1004138
https://doi.org/10.1021/cr1004138
Publikováno v:
Journal of Fluorine Chemistry. 121:101-104
An improved procedure for the radical addition of a,o-diiodoperfluoroalkanes I‐(CF2CF2)n‐I (na 2, 3) to allyl acetate that afford the corresponding bis-adducts AcOCH2CHICH2(CF2CF2)nCH2CHI‐CH2OAc (2a‐2b) has been developed. The primary bis-add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4599af5f296f18ef812dc13a4f10551b
https://doi.org/10.1016/s0022-1139(03)00006-x
https://doi.org/10.1016/s0022-1139(03)00006-x
Publikováno v:
Tetrahedron Letters. 52:2940-2942
Guanofosfocins are strong inhibitors of chitin synthases, but also very prone to hydrolytic cleavage. Two advanced intermediates 15 and 20 for the synthesis of stable di-carba-guanofosfocins were prepared via ester 11. Acylation of the allylic C-glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::061945b9d061eddd00cec4b16f84ac0b
https://doi.org/10.1016/j.tetlet.2011.02.102
https://doi.org/10.1016/j.tetlet.2011.02.102
Publikováno v:
ChemInform. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b359409b41a2cf3fd2c338c31eef373
https://doi.org/10.1002/chin.201144230
https://doi.org/10.1002/chin.201144230
Autor:
Andrea Vasella, Jan Duchek
Publikováno v:
ChemInform. 42
The reactions of ortho-nitroanilides and the pyridine-derived analogue (XI) afford the 2-substituted benzimidazoles and imidazopyridine respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab5a285c38b279a2a013deb063353ba
https://doi.org/10.1002/chin.201141114
https://doi.org/10.1002/chin.201141114
Autor:
Martin Přádný, Jana Wichterlová, Jan Duchek, Robert Kaplánek, Jiří Michálek, Oldřich Paleta, Dana Chmelíková, Vladimír Církva
Publikováno v:
European journal of medicinal chemistry. 41(11)
Perfluoroalkylated methacrylates 7a – c bearing sulfinyl group within a straight-chain ester group, i.e. CH 2 =C(CH 3 )CO 2 CH 2 CH 2 S(O)–CH 2 CH 2 CF 2 (CF 2 CF 2 ) n CF 3 ( n = 1–3) were prepared by two alternative synthetic sequences from 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1764c6f7fd25c0909b08a3e5b9aa9b
https://pubmed.ncbi.nlm.nih.gov/16889874
https://pubmed.ncbi.nlm.nih.gov/16889874