Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jan Dobes"'
Autor:
Vladimir Korinek, Hynek Strnad, Katerina Galuskova, Eva Sloncova, Jitka Stancikova, Adela Hlavata, Monika Horazna, Nikol Baloghova, Dominique Leprince, Marion Dubuissez, Jan Dobes, Jolana Tureckova, Martina Vojtechova, Bohumil Fafilek, Vendula Pospichalova, Lucie Janeckova
Supplementary Figures S1-3, Tables S1-3. Supplementary Figure S1. Heatmaps depicting gene expression in Hic1flox/flox MEFs treated with 4- OHT when compared to MEFs treated with vehicle (ethanol) only. Genes (299 in total) displaying significantly (q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440d8b5f04d038210d2bc49664dc3652
https://doi.org/10.1158/1541-7786.22511505.v1
https://doi.org/10.1158/1541-7786.22511505.v1
Autor:
Vladimir Korinek, Hynek Strnad, Katerina Galuskova, Eva Sloncova, Jitka Stancikova, Adela Hlavata, Monika Horazna, Nikol Baloghova, Dominique Leprince, Marion Dubuissez, Jan Dobes, Jolana Tureckova, Martina Vojtechova, Bohumil Fafilek, Vendula Pospichalova, Lucie Janeckova
Hypermethylated in cancer 1 (HIC1) represents a prototypic tumor suppressor gene frequently inactivated by DNA methylation in many types of solid tumors. The gene encodes a sequence-specific transcriptional repressor controlling expression of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facf38d4d0dcc89d54095088de5ec890
https://doi.org/10.1158/1541-7786.c.6539961.v1
https://doi.org/10.1158/1541-7786.c.6539961.v1
Autor:
Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bähr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
Publikováno v:
Science Immunology. 7
FOXN1 is a transcription factor critical for the development of both thymic epithelial cell (TEC) and hair follicle cell (HFC) compartments. However, mechanisms controlling its expression remain poorly understood. To address this question, we perform
Autor:
Richard S. Blumberg, Jan Dobes, O. Ballek, Dominik Filipp, M. Voboril, Martina Dobešová, J. Manning, J. Brezina, Tomáš Brabec
Medullary thymic epithelial cells (mTECs) which produce and present self-antigens are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91ed5b529a8a17b85366e12602b0d0b
https://doi.org/10.1101/2021.09.13.460045
https://doi.org/10.1101/2021.09.13.460045
Autor:
Dominik Filipp, Vladimir Benes, Ludger Klein, Radislav Sedlacek, Matouš Vobořil, Michal Kolář, Madlen Steinert, Rikinari Hanayama, Natalia Ziętara, Tomáš Brabec, Jan Dobes, Caspar Ohnmacht, Martina Dobešová, Tomoyoshi Yamano, Martti Laan, Pärt Peterson
Publikováno v:
J. Exp. Med. 216, 1027-1037 (2019)
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the "promiscuous" expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ba22291044c6345492f89ef5d8f0eb
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55784
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55784
Publikováno v:
2018 Smart City Symposium Prague (SCSP).
Virtual power plants using spare capacity of standing plugged-in electric vehicles (EV) is an innovative system which will be able to cope with power grid instabilities brought by intermittent renewables. Bottleneck for its application is however the
Autor:
Matouš Vobořil, Jiří Březina, Tomáš Brabec, Jan Dobeš, Ondřej Ballek, Martina Dobešová, Jasper Manning, Richard S Blumberg, Dominik Filipp
Publikováno v:
eLife, Vol 11 (2022)
Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transf
Externí odkaz:
https://doaj.org/article/2ae0f9be8910423e819ebff66ddf8eea
Autor:
Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like recepto
Externí odkaz:
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Autor:
Cristina Peligero-Cruz, Tal Givony, Arnau Sebé-Pedrós, Jan Dobeš, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson
Publikováno v:
eLife, Vol 9 (2020)
Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitu
Externí odkaz:
https://doaj.org/article/03a010dc029243e1bd1fd7afe17ebdb1
Publikováno v:
Journal of Physics: A Mathematical & General; Aug2006, Vol. 39 Issue 31, pL515-L521, 7p