Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jan Detka"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4354 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by the formation of amyloid β and tau protein aggregates in the brain, neuroinflammation, impaired cholinergic neurotransmission, and oxidative stress, resulting in the gradua
Externí odkaz:
https://doaj.org/article/c236341de8064b2ab1ed28f95ca7edd4
Autor:
Martyna Strzelec, Jan Detka, Patrycja Mieszczak, Małgorzata Katarzyna Sobocińska, Marcin Majka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In recent years, there has been a tremendous development of biotechnological, pharmacological, and medical techniques which can be implemented in the functional modulation of the immune system components. Immunomodulation has attracted much attention
Externí odkaz:
https://doaj.org/article/31ea2fd3c0774e35bc59f7283a7ee576
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Although hypothyroidism appears to be an important factor in the pathogenesis of depression, the impact of thyroid hormones on the bioenergetics of the adult brain is still poorly known. Since metabolic changes are reported to be a key player in the
Externí odkaz:
https://doaj.org/article/5b1d11655406492191a7f8683bd18a82
Publikováno v:
Cells, Vol 10, Iss 11, p 2937 (2021)
The developing and adult brain is a target organ for the vast majority of hormones produced by the body, which are able to cross the blood–brain barrier and bind to their specific receptors on neurons and glial cells. Hormones ensure proper communi
Externí odkaz:
https://doaj.org/article/2df42c7232ad44ceb704b18dbdc7cd5b
Publikováno v:
Cells, Vol 10, Iss 6, p 1394 (2021)
The clinical effectiveness of supportive therapy with thyroid hormones in drug-resistant depression is well-known; however, the mechanisms of action of these hormones in the adult brain have not been fully elucidated to date. We determined the effect
Externí odkaz:
https://doaj.org/article/42670779ea214b159b88d0cd70530abd
Autor:
Katarzyna Głombik, Magdalena Kukla-Bartoszek, Katarzyna Curzytek, Jan Detka, Agnieszka Basta-Kaim, Bogusława Budziszewska
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1156
Since depression produces a long-term negative impact on quality of life, understanding the pathophysiological changes implicated in this disorder is urgent. There is growing evidence that demonstrates a key role for dysfunctional energy metabolism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cee72029a2ee65c6b01e45ca83146e5
https://ruj.uj.edu.pl/xmlui/handle/item/308402
https://ruj.uj.edu.pl/xmlui/handle/item/308402
Autor:
Jan Detka, Katarzyna Głombik
Publikováno v:
Pharmacological Reports
Depression is a highly prevalent mood disorder and one of the major health concerns in modern society. Moreover, it is characterized by a high prevalence of coexistence with many other diseases including metabolic disorders such as type 2 diabetes me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589f428a968dd548b5a8a2d7b1ff1c37
http://europepmc.org/articles/PMC8413152
http://europepmc.org/articles/PMC8413152
Autor:
Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewska
Publikováno v:
Pharmacological reports : PR. 74(5)
Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be intensified by a deficiency of thyroid hormones. In contrast to glucose metabolism, the link between altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271557bd9977095875c905484726730
https://pubmed.ncbi.nlm.nih.gov/35951260
https://pubmed.ncbi.nlm.nih.gov/35951260
Publikováno v:
Cells, Vol 10, Iss 2937, p 2937 (2021)
Cells
Cells
The developing and adult brain is a target organ for the vast majority of hormones produced by the body, which are able to cross the blood–brain barrier and bind to their specific receptors on neurons and glial cells. Hormones ensure proper communi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3082ee78f8269bd4f57c75136c57ec
https://www.mdpi.com/2073-4409/10/11/2937
https://www.mdpi.com/2073-4409/10/11/2937
Autor:
Katarzyna Głombik, Bartosz Bobula, Magdalena Kusek, Joanna Bąk, Krzysztof Tokarski, Jan Detka, Bogusława Budziszewska
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1599, p 1599 (2021)
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1599, p 1599 (2021)
The role that thyroid hormone deficiency plays in depression and synaptic plasticity in adults has only begun to be elucidated. This paper analyzes the possible link between depression and hypothyroidism in cognitive function alterations, using Wista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995cb1e34f2b3b1315bf272599f49e2c