Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Jan De Hoon"'
Autor:
Ramesh Boinpally, Marleen Depré, Griet Van Lancker, Marissa F Dockendorf, Phung Bondiskey, Jean-Francois Denef, Tom Reynders, Catherine Zhou Matthews, K Chris Min, Jialin Xu, Joel M Trugman, Jan de Hoon
Publikováno v:
Cephalalgia Reports, Vol 6 (2023)
Background/Hypothesis: Atogepant, an oral calcitonin gene-related peptide receptor antagonist, is approved for the preventive treatment of migraine in adults. This manuscript characterizes the safety, tolerability, pharmacokinetics and pharmacokineti
Externí odkaz:
https://doaj.org/article/5322ddc1d94045a5bbfac12682cc3682
Autor:
Heleen Marynissen, Linde Buntinx, Dorien Bamps, Marleen Depre, Els Ampe, Anne Van Hecken, Kristin Gabriel, Steve Sands, Gabriel Vargas, Jan de Hoon
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 1968-1977 (2022)
Abstract Maxadilan, a potent vasodilator peptide, selectively activates the PAC1 receptor, a promising target for migraine therapy. Therefore, maxadilan has been suggested as a tool to study the pharmacodynamics (PDs) of PAC1 receptor antagonists. Th
Externí odkaz:
https://doaj.org/article/5f31137aa46647bc88467882c8d81c9b
Autor:
Wouter Botermans, Michel Koole, Koen Van Laere, Jonathan R. Savidge, John A. Kemp, Stefan Sunaert, Maeve M. Duffy, Steven Ramael, Andrea M. Cesura, Kevin D’Ostilio, Denis Gossen, Torsten M. Madsen, Thomas Lodeweyckx, Jan de Hoon
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Background: Current treatments for progressive neurodegenerative disorders characterized by cognitive impairment either have limited efficacy or are lacking altogether. SDI-118 is a small molecule which modulates the activity of synaptic vesicle glyc
Externí odkaz:
https://doaj.org/article/df0ee95e51f84642be55f2415ae1522e
Autor:
Nathalie Mertens, Mark E. Schmidt, Anja Hijzen, Donatienne Van Weehaeghe, Paulien Ravenstijn, Marleen Depre, Jan de Hoon, Koen Van Laere, Michel Koole
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract [18F]JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a metabolite-corrected arterial plasma input function. In the context of a P2
Externí odkaz:
https://doaj.org/article/956ae6697f2b4d23a1f6acaf3aaf905f
Autor:
Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere, Michel Koole
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-11 (2021)
Abstract Rationale [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two versions of the OLI
Externí odkaz:
https://doaj.org/article/dcd084ea376c46a987d154271c5ed03c
Autor:
Francesca Maria Russo, Alexandra Benachi, Tim Van Mieghem, Jan De Hoon, Kristel Van Calsteren, Pieter Annaert, Jean-Marc Tréluyer, Karel Allegaert, Jan Deprest
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Background Congenital diaphragmatic hernia is an orphan disease with high neonatal mortality and significant morbidity. An important cause for this is pulmonary hypertension, for which no effective postnatal therapy is available to date. An
Externí odkaz:
https://doaj.org/article/38f9c182c9fd4c8e82b0afe9fe805d7e
Autor:
Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was condu
Externí odkaz:
https://doaj.org/article/8a63134b5d524c8e93bb47088beac1b1
Autor:
Kerstin Breithaupt-Grögler, Tim Hardman, Jan de Hoon, Yves Donazzolo, Sylvie Rottey, Hildegard Sourgens, Steffan Stringer
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The European Federation for Exploratory Medicines Development (EUFEMED) organized a meeting in Leuven, Belgium entitled ‘The new FIH EMA guideline: Disruptive or constructive?’ to provide a forum for stakeholders to discuss the guideline’s oper
Externí odkaz:
https://doaj.org/article/b23e4873d6a34cf49989b280af3ddd46
Autor:
Luc Van Bortel, Hildegard Sourgens, Kerstin Breithaupt-Grögler, Henri Caplain, Yves Donazzolo, Ingrid Klingmann, Michael Hammond, Timothy C. Hardman, Steffan Stringer, Jan de Hoon
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
The first formal conference of the EUropean Federation for Exploratory MEdicines Development (EUFEMED) held in London was the result of a collaborative effort of its founding associations: the Association for Applied Human Pharmacology (AGAH; Germany
Externí odkaz:
https://doaj.org/article/e8d56503f6a649c0a713009e2c78b9b5
Autor:
David Monteith, Emily C. Collins, Corinne Vandermeulen, Anne Van Hecken, Eyas Raddad, Joel C. Scherer, David Grayzel, Thomas J. Schuetz, Jan de Hoon
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Background: Calcitonin gene-related peptide (CGRP) is pivotal in the pathophysiology of migraine headaches and represents a promising target for migraine treatment. The humanized monoclonal antibody galcanezumab (LY2951742) binds to CGRP and may be e
Externí odkaz:
https://doaj.org/article/575cfbd32890489aa7734d36b48339e5