Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Jan D. Haas"'
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Akademický článek
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
Autor: Jan D Haas, Kiran Nistala, Franziska Petermann, Namita Saran, Vijaykumar Chennupati, Susanne Schmitz, Thomas Korn, Lucy R Wedderburn, Reinhold Förster, Andreas Krueger, Immo Prinz
Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20171 (2011)
Differentiation of T helper 17 cells (Th17) is a multistep process that involves the cytokines IL-6, TGF-β, and IL-23 as well as IL-1β, IL-21, and TNF-α. Thereby, robust induction of the capacity to produce IL-17 involves epigenetic modifications
Externí odkaz: https://doaj.org/article/bed165c268e341f991d0911b65c3c69d
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2
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis
Autor: Stefan Steidl, Stéphanie Lavazais, Maté Ongenaert, Maarten Van Balen, Catherine Jagerschmidt, Kilian Eyerich, M. Auberval, Nick Vandeghinste, Jan D. Haas, L. Lepescheux, F. Marsais, Reginald Brys, Teresa Garcia, Jürgen Klattig, Stefan Härtle, Sonia Dupont, F. Lauffer, Padraic G. Fallon, Tara Moran
Publikováno v: Journal of Investigative Dermatology
IL-17C is a functionally distinct member of the IL-17 family that was believed to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ccf4284964d33d9eab7523236662f7
https://pubmed.ncbi.nlm.nih.gov/29941097
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3
CCR7-mediated migration in the thymus controls γδ T-cell development
Autor: Marcin Łyszkiewicz, Henrike Fleige, Annika Reinhardt, Jan D. Haas, Immo Prinz, Linda Oberdörfer, Reinhold Förster, Sarina Ravens
Publikováno v: European Journal of Immunology. 44:1320-1329
αβ T-cell development and selection proceed while thymocytes successively migrate through distinct regions of the thymus. For γδ T cells, the interplay of intrathymic migration and cell differentiation is less well understood. Here, we crossed C-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3681c6e15403abc2ee6e0395828235e7
https://doi.org/10.1002/eji.201344330
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4
γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism
Autor: Bernhard Hemmer, Lorena Riol Blanco, Vijay K. Kuchroo, Veit Rothhammer, Immo Prinz, Malte C. Claussen, Sylvia Heink, Jan D. Haas, Franziska Petermann, Thomas Korn, Mohamed Oukka
Publikováno v: Immunity. 33(3):351-363
Summary Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of γδ T cells expresses the IL-23 receptor (IL-23R) constitutively. Using IL-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9987cdcb19e0cea3e6135c0c6a04bd81
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5
CCR6 and NK1.1 distinguish between IL-17A and IFN-γ-producing γδ effector T cells
Autor: Frano H. Malinarich González, Susanne Schmitz, Vijaykumar Chennupati, Immo Prinz, Lisa Föhse, Reinhold Förster, Elisabeth Kremmer, Jan D. Haas
Publikováno v: European Journal of Immunology. 39:3488-3497
Gammadelta T cells are a potent source of innate IL-17A and IFN-gamma, and they acquire the capacity to produce these cytokines within the thymus. However, the precise stages and required signals that guide this differentiation are unclear. Here we s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de1d197c6d0b2d7d3cba06968941743
https://doi.org/10.1002/eji.200939922
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7
CCR7-mediated migration in the thymus controls γδ T-cell development
Autor: Annika, Reinhardt, Sarina, Ravens, Henrike, Fleige, Jan D, Haas, Linda, Oberdörfer, Marcin, Łyszkiewicz, Reinhold, Förster, Immo, Prinz
Publikováno v: European journal of immunology. 44(5)
αβ T-cell development and selection proceed while thymocytes successively migrate through distinct regions of the thymus. For γδ T cells, the interplay of intrathymic migration and cell differentiation is less well understood. Here, we crossed C-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::566d6a320d72d84a4665f8e71cfb5b49
https://pubmed.ncbi.nlm.nih.gov/24500801
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8
Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients
Autor: Anika Dreier, Gertrud Vieten, Faikah Gueler, Claus Petersen, Stephanie Dippel, Arne Schröder, Johannes Leonhardt, Anja Thorenz, Nora Möhn, Yi Yu, Immo Prinz, Anne Wilde, Jan D. Haas, Eva Tolosa, Thomas Winterberg, Anne Jörns, Joachim F. Kuebler, Christian Klemann
Publikováno v: Gastroenterology. 150:229-241.e5
Background & Aims Biliary atresia (BA) is a rare disease in infants, with unknown mechanisms of pathogenesis. It is characterized by hepatobiliary inflammatory, progressive destruction of the biliary system leading to liver fibrosis, and deterioratio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1315b490102facf77fc2a1b745704f4a
https://doi.org/10.1053/j.gastro.2015.09.008
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9
Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave
Autor: Siegfried Weiss, Jan D. Haas, Sarina Ravens, Vijaykumar Chennupati, Elham Kashani, Ronald Naumann, Inga Sandrock, Immo Prinz, Andreas Krueger, Linda Oberdörfer, Sandra Düber, Lisa Föhse, Reinhold Förster
Publikováno v: Immunity. 37(1)
Summaryγδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic dev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49483f8c16a7cc26885b9faa2e20919c
https://pubmed.ncbi.nlm.nih.gov/22770884
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10
High TCR diversity ensures optimal function and homeostasis of Foxp3+ regulatory T cells
Autor: Lisa Föhse, Reinhold Förster, Chun Wei Lee, Christian Koenecke, Jan D. Haas, Karsten Suhre, André Bleich, Cornelia Lindner, Bernard Malissen, Sebastian Suerbaum, Immo Prinz, Benjamin Wahl, Günter J. Hämmerling, Janine Suffner, Stella Lamprecht, Susanne Schmitz
Publikováno v: Eur. J. Immunol. 41, 3101-3113 (2011)
European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
European Journal of Immunology, 2011, 41 (11), pp.3101-13. ⟨10.1002/eji.201141986⟩
International audience; Dominant tolerance to self-antigen requires the presence of sufficient numbers of CD4(+) Foxp3(+) Treg cells with matching antigen specificity. However, the size and role of TCR repertoire diversity for antigen-specific immuno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006e6a498c195afe171583d470f18f27
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6917
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