Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Jan Dörr"'
Autor:
Priscilla Bäcker‐Koduah, Carmen Infante‐Duarte, Federico Ivaldi, Antonio Uccelli, Judith Bellmann‐Strobl, Klaus‐Dieter Wernecke, Michael Sy, Michael Demetriou, Jan Dörr, Friedemann Paul, Alexander Ulrich Brandt
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1628-1641 (2020)
Abstract Objective To investigate the effect of cholecalciferol (vitamin D3) supplementation on peripheral immune cell frequency and N‐glycan branching in patients with relapsing‐remitting multiple sclerosis (RRMS). Methods Exploratory analysis o
Externí odkaz:
https://doaj.org/article/aa6f42d2d53b4fc0a2293fe6df8f88d8
Autor:
Christian Albert, Janine Mikolajczak, Anja Liekfeld, Sophie K. Piper, Michael Scheel, Hanna G. Zimmermann, Claus Nowak, Jan Dörr, Judith Bellmann-Strobl, Claudia Chien, Alexander U. Brandt, Friedemann Paul, Olaf Hoffmann
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Neuroprotection and promotion of remyelination represent important therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS manifestation. Based on the presence and properties of sphingosine-1-phosph
Externí odkaz:
https://doaj.org/article/2d7d38ec7298453fba53a4451db2975a
Autor:
Catharina C. Gross, Céline Meyer, Urvashi Bhatia, Lidia Yshii, Ilka Kleffner, Jan Bauer, Anna R. Tröscher, Andreas Schulte-Mecklenbeck, Sebastian Herich, Tilman Schneider-Hohendorf, Henrike Plate, Tanja Kuhlmann, Markus Schwaninger, Wolfgang Brück, Marc Pawlitzki, David-Axel Laplaud, Delphine Loussouarn, John Parratt, Michael Barnett, Michael E. Buckland, Todd A. Hardy, Stephen W. Reddel, Marius Ringelstein, Jan Dörr, Brigitte Wildemann, Markus Kraemer, Hans Lassmann, Romana Höftberger, Eduardo Beltrán, Klaus Dornmair, Nicholas Schwab, Luisa Klotz, Sven G. Meuth, Guillaume Martin-Blondel, Heinz Wiendl, Roland Liblau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model,
Externí odkaz:
https://doaj.org/article/4c98395f104445a7a39848447428e6cc
Autor:
Katharina Klumbies, Rebekka Rust, Jan Dörr, Frank Konietschke, Friedemann Paul, Judith Bellmann-Strobl, Alexander U. Brandt, Hanna G. Zimmermann
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Epigallocatechin gallate (EGCG) is an anti-inflammatory agent and has proven neuroprotective properties in animal models of multiple sclerosis (MS). Optical coherence tomography (OCT) assessed retinal thickness analysis can reflect treatm
Externí odkaz:
https://doaj.org/article/4b04c8086aea49df9cfbcb6cc4433c37
Autor:
Priscilla Bäcker-Koduah, Judith Bellmann-Strobl, Michael Scheel, Jens Wuerfel, Klaus-Dieter Wernecke, Jan Dörr, Alexander Ulrich Brandt, Friedemann Paul
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients.Methods: In 51 RRMS and 2 CIS patients on stable in
Externí odkaz:
https://doaj.org/article/7788d113409a4885ad5dcd84a4efd6d5
Autor:
Jan Dörr, Klaus-Dieter Wernecke, Jens Würfel, Judith Bellmann-Strobl, Volker Siffrin, Muriel B. Sättler, Mikael Simons, Andreas Linsa, Hayrettin Tumani, Friedemann Paul
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Central nervous system inflammation and neurodegeneration are the pathophysiological hallmarks of multiple sclerosis (MS). While inflammation can readily be targeted by current disease modifying drugs, neurodegeneration is by far less accessible to t
Externí odkaz:
https://doaj.org/article/4cbe7e5f26fc45e3b7bc8efb3898db69
Autor:
Ludwig Rasche, Lisa Heiserich, Janina Ruth Behrens, Klaus Lenz, Catherina Pfuhl, Katharina Wakonig, René Markus Gieß, Erik Freitag, Caroline Eberle, Jens Wuerfel, Jan Dörr, Peter Bauer, Judith Bellmann-Strobl, Friedemann Paul, Dirk Roggenbuck, Klemens Ruprecht
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147968 (2016)
BACKGROUND:In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as γ-H2AX. Formation of γ-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1
Externí odkaz:
https://doaj.org/article/65d7438056b149d29e45545d44831cac
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99106 (2014)
BACKGROUND:Multiple sclerosis (MS) preferentially affects females at childbearing age. For this reason patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth. OBJECTIVE:The aim of th
Externí odkaz:
https://doaj.org/article/196c2888432d4aaba942ce08b085675c
Autor:
Anke Stroet, Claudia Hemmelmann, Michaela Starck, Uwe Zettl, Jan Dörr, Friedemann Paul, Peter Flachenecker, Vinzenz Fleischer, Frauke Zipp, Holger Nückel, Bernd C Kieseier, Andreas Ziegler, Ralf Gold, Andrew Chan
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 5 (2012)
Background: The incidence of therapy-related acute leukaemia (TRAL) in mitoxantrone treatment in multiple sclerosis (MS) is controversially discussed. Methods and results: In a retrospective meta-analysis from six centres, we observed six cases of ac
Externí odkaz:
https://doaj.org/article/8709d2e62d4e4f8090bcca2c7e28a3a9
Autor:
Coralie Chanvillard, Jason M Millward, Marta Lozano, Isabell Hamann, Friedemann Paul, Frauke Zipp, Jan Dörr, Carmen Infante-Duarte
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39625 (2012)
Mitoxantrone is one of the few drugs approved for the treatment of progressive multiple sclerosis (MS). However, the prolonged use of this potent immunosuppressive agent is limited by the appearance of severe side effects. Apart from its general cyto
Externí odkaz:
https://doaj.org/article/c55664edcf084ee19141d3c0f2cddf6c