Chancellor Wu Leichuan: A Confucian-Christian Educator

Autor: Sin-Jan, Chu, author

Publikováno v: New Perspectives on Yenching University, 1916–1952: A Liberal Education for a New China. :215-236

Dual Antigen Targeting with Co-Transduced CD19/22 CAR T Cells May Prevent Antigen-Negative Relapse after CAR T Cell Therapy for Relapsed/Refractory ALL

Autor: Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Evangelia K Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Katherine Clesham, Denise Bonney, Robert F Wynn, Martin Pule, Rachael E Hough, Persis J Amrolia

Publikováno v: Blood. 140:10352-10354

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea12492684ee229651c495469b5c0218
https://doi.org/10.1182/blood-2022-164879

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia

Autor: Giorgio, Ottaviano, Christos, Georgiadis, Soragia Athina, Gkazi, Farhatullah, Syed, Hong, Zhan, Annie, Etuk, Roland, Preece, Jan, Chu, Agnieszka, Kubat, Stuart, Adams, Paul, Veys, Ajay, Vora, Kanchan, Rao, Waseem, Qasim, Daesik, Kim

Publikováno v: Science translational medicine. 14(668)

Genome editing of allogeneic T cells can provide “off-the-shelf” alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T cell receptor α chain (TRAC) to prevent graft-versus-host disease (GVHD) and removal of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5809002722a12c073d450d9e359bc78d
https://pubmed.ncbi.nlm.nih.gov/36288281

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

Autor: Reuben Benjamin, Charlotte Graham, Deborah Yallop, Agnieszka Jozwik, Oana C Mirci-Danicar, Giovanna Lucchini, Danielle Pinner, Nitin Jain, Hagop Kantarjian, Nicolas Boissel, Marcela V Maus, Matthew J Frigault, André Baruchel, Mohamad Mohty, Athos Gianella-Borradori, Florence Binlich, Svetlana Balandraud, Fabien Vitry, Elisabeth Thomas, Anne Philippe, Sylvain Fouliard, Sandra Dupouy, Ibtissam Marchiq, Maria Almena-Carrasco, Nicolas Ferry, Sylvain Arnould, Cyril Konto, Paul Veys, Waseem Qasim, Antonio Pagliuca, Ghulam Mufti, Piers Patten, Shireen Kassam, Stephen Devereux, Majid Kazmi, Kirsty Cuthill, Victoria Potter, Andrea Kuhnl, Victoria Metaxa, Laarni Bonganay, Orla Stewart, Rose Ellard, Lorraine Catt, Jen Lewis, Farzin Farzaneh, Jackie Chappell, Alice Mason, Vicky Chu, Alan Dunlop, Adeel Saleem, Gary Cheung, Helena Munro, Elka Giemza, Oana Ciocarlie, Jan Chu, Persis Amrolia, Kanchan Rao, Robert Chiesa, Juliana Silva, Annette Hill, Maria Finch, Lindsey Young, Harvinder Hara, Sujith Samarasinghe, Anupama Rao, Ajay Vora, Kimberley Gilmour, Christine Rivat, Clare Murphy, Gulrukh Ahsan, Rasha Said Shamsah, Jesmina James, Sarah Inglott, Gary Wright, Stuart Adams, Natalia Izotova, Marina Konopleva, William Wierda, Elias Jabbour, Partow Kebrieai, Emily Jones, Kara McGee, Marcela Maus, Matthew Frigault, Jami Brown, Vesselina Toncheva, Keagan Casey, Hanno Hock, Meaghan A McKeown, Richard Mathews, Thomas Spitzer, Emmanuel Raffoux, Etienne Lengliné, Raphael Itzykson, Florence Rabian, Jérôme Larghero, Isabelle Madelaine, Elie Azoulay, Emmanuelle Clappier, Sophie Caillat-Zucman, Martine Meunier, Karine Celli-Lebras, Marie-Thérèse Tremorin, Karima Yakouben, Françoise Mechinaud-Heloury, Audrey Grain, Aurélia Alimi, Julie Roupret, Delphine Chaillou, Hélène Cavé, Aurelie Caye-Eude, Odile Fenneteau, Elodie Lainey, Jerome Naudin, Eolia Brissot, Remy Dulery, Florent Malard, Clémence Mediavilla, Agnès Bonnin, Anne Vekhoff, Tounes Ledraa, Anne Daguenel-Nguyen

Publikováno v: The Lancet. 396:1885-1894

Summary Background Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for immediate clinical use, thereby broadening access and applicability. UCART19 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec40a8b13cd2746d839da37388e3ee8
https://doi.org/10.1016/s0140-6736(20)32334-5

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

Autor: Anne Marijn Kramer, Juliana Silva, Rachel Richardson, Andre Lopes, Patrycja Wawrzyniecka, Robert Wynn, Kanchan Rao, Bilyana Popova, Shimobi Onuoha, Gulrukh Ahsan, Paul Veys, Jenny Yeung, Aleks Guvenel, Gary Wright, Giovanna Lucchini, Krystle Villanueva, Mathieu Ferrari, Farzin Farzaneh, Winston Vetharoy, Denise Bonney, Jack Bartram, Fernanda Castro, Leila Mekkaoui, Sara Ghorashian, Joan Casanovas-Company, Somayya Manzoor, Persis Amrolia, Jan Chu, Tony Brooks, Danielle Pinner, Kim Champion, Rachael Hough, Sarah J. Albon, Ajay Vora, Robert Chiesa, Nicholas Goulden, Arina Lazareva, Martin Pule, Kimberly Gilmour, Oana Ciocarlie, Sujith Samarasinghe, Gordon Weng-Kit Cheung, Sarah Inglott, Allan Hackshaw

Publikováno v: Nature Medicine. 25:1408-1414

Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL)1–5, but toxicity, including cytokine-release syndrome (CRS) and neurotoxicity, limits broad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac4abbbd455e5d0aed7e8f2a0b6879a
https://doi.org/10.1038/s41591-019-0549-5