Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jan Christoph Koch"'
Autor:
Xiaoyue Luo, Jiong Zhang, Johan Tolö, Sebastian Kügler, Uwe Michel, Mathias Bähr, Jan Christoph Koch
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Neurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophagic vesicles (AVs) are formed at the tip of the axon and transported back to the soma. This transport is essential since
Externí odkaz:
https://doaj.org/article/d5a068e86bc84055a1b36ac964e27bef
Autor:
René Günther, Claudia Diana Wurster, Svenja Brakemeier, Alma Osmanovic, Olivia Schreiber-Katz, Susanne Petri, Zeljko Uzelac, Miriam Hiebeler, Simone Thiele, Maggie C. Walter, Markus Weiler, Tobias Kessler, Maren Freigang, Hanna Sophie Lapp, Isabell Cordts, Paul Lingor, Marcus Deschauer, Andreas Hahn, Kyriakos Martakis, Robert Steinbach, Benjamin Ilse, Annekathrin Rödiger, Julia Bellut, Julia Nentwich, Daniel Zeller, Mohamad Tareq Muhandes, Tobias Baum, Jan Christoph Koch, Bertold Schrank, Sophie Fischer, Andreas Hermann, Christoph Kamm, Steffen Naegel, Alexander Mensch, Markus Weber, Christoph Neuwirth, Helmar C. Lehmann, Gilbert Wunderlich, Christian Stadler, Maike Tomforde, Annette George, Martin Groß, Astrid Pechmann, Janbernd Kirschner, Matthias Türk, Mareike Schimmel, Günther Bernert, Pascal Martin, Christian Rauscher, Gerd Meyer zu Hörste, Petra Baum, Wolfgang Löscher, Marina Flotats-Bastardas, Cornelia Köhler, Kristina Probst-Schendzielorz, Susanne Goldbach, Ulrike Schara-Schmidt, Wolfgang Müller-Felber, Hanns Lochmüller, Otgonzul von Velsen, Christoph Kleinschnitz, Albert C. Ludolph, Tim Hagenacker
Publikováno v:
The Lancet Regional Health. Europe, Vol 39, Iss , Pp 100862- (2024)
Summary: Background: Evidence for the efficacy of nusinersen in adults with 5q-associated spinal muscular atrophy (SMA) has been demonstrated up to a period of 16 months in relatively large cohorts but whereas patients reach a plateau over time is st
Externí odkaz:
https://doaj.org/article/290d74c1de7d42b58be5fe3b14b68827
Autor:
Uwe Michel, Orr Shomroni, Barbara Müller, Peter Lange, Gabriela Salinas, Mathias Bähr, Jan Christoph Koch
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Next generation sequencing (NGS) of human specimen is expected to improve prognosis and diagnosis of human diseases, but its sensitivity urges for well-defined sampling and standardized protocols in order to avoid error-prone conc
Externí odkaz:
https://doaj.org/article/d2d9d561a4d646dda274834b076a9893
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The axonal cytoskeleton is organized in a highly periodic structure, the membrane-associated periodic skeleton (MPS), which is essential to maintain the structure and function of the axon. Here, we use stimulated emission depletion microscop
Externí odkaz:
https://doaj.org/article/5f9798e3e4724ca193c22b04e3108f17
Autor:
André Maier, Marcel Gaudlitz, Torsten Grehl, Ute Weyen, Robert Steinbach, Julian Grosskreutz, Annekathrin Rödiger, Jan Christoph Koch, Teresa Lengenfeld, Patrick Weydt, René Günther, Joachim Wolf, Petra Baum, Moritz Metelmann, Johannes Dorst, Albert C. Ludolph, Dagmar Kettemann, Jenny Norden, Ruhan Yasemin Koc, Bertram Walter, Barbara Hildebrandt, Christoph Münch, Thomas Meyer, Susanne Spittel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Motor-assisted movement exercisers (MME) are devices that assist with physical therapy in domestic settings for people living with ALS. This observational cross-sectional study assesses the subjective experience of the therapy and analyzes u
Externí odkaz:
https://doaj.org/article/dae52e8c7c1148c0af7cde27ad70d10c
Autor:
Maren Freigang, Petra Steinacker, Claudia Diana Wurster, Olivia Schreiber-Katz, Alma Osmanovic, Susanne Petri, Jan Christoph Koch, Kevin Rostásy, Björn Falkenburger, Albert Christian Ludolph, Markus Otto, Andreas Hermann, René Günther
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Studies regarding the impact of (neuro)inflammation and inflammatory response following repetitive, intrathecally administered antisense oligonucleotides (ASO) in 5q-associated spinal muscular atrophy (SMA) are sparse. Increased r
Externí odkaz:
https://doaj.org/article/0cde2deffee34edd83dfefc691547d42
Autor:
Tanja Dučić, Jan Christoph Koch
Publikováno v:
Cells, Vol 12, Iss 11, p 1451 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with the most common adult-onset neurodegenerative disorder affecting motoneurons. Although disruptions in macromolecular conformation and homeostasis have been described in as
Externí odkaz:
https://doaj.org/article/29afed2aabf8481999fe6819bbfc20da
Autor:
Vinicius Toledo Ribas, Björn Friedhelm Vahsen, Lars Tatenhorst, Veronica Estrada, Vivian Dambeck, Raquel Alves Almeida, Mathias Bähr, Uwe Michel, Jan Christoph Koch, Hans Werner Müller, Paul Lingor
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Abstract Axonal damage is an early step in traumatic and neurodegenerative disorders of the central nervous system (CNS). Damaged axons are not able to regenerate sufficiently in the adult mammalian CNS, leading to permanent neurological deficits. Re
Externí odkaz:
https://doaj.org/article/a790b1ee6c5d4e2481f7473590482877
Autor:
Mariana Santana Dias, Xiaoyue Luo, Vinicius Toledo Ribas, Hilda Petrs-Silva, Jan Christoph Koch
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3935 (2022)
Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and leads to progressive vision loss. The first pathological signs can be seen at the optic nerve head (ONH), the structure where RGC axons leave the retina to com
Externí odkaz:
https://doaj.org/article/1eb7c90db7904b74aef067b6bf9b4c44
Autor:
Caroline Gertrud Bergner, Christiane Michaela Neuhofer, Claudia Funke, Saskia Biskup, Philipp von Gottberg, Claudia Bartels, Jan Christoph Koch, Katrin Radenbach
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
BackgroundModern genetics have in many ways revolutionized clinical routine and have, for instance, shown that formerly distinct disease entities relate to common pathogenic mutations. One such example is the connection between dementia and amyotroph
Externí odkaz:
https://doaj.org/article/f64272f638b34bf59a29f18efb75aca2