Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jan C. Koch"'
Autor:
Jochen H. Weishaupt, Péter Körtvélyessy, Peggy Schumann, Ivan Valkadinov, Ute Weyen, Jasper Hesebeck-Brinckmann, Kanchi Weishaupt, Matthias Endres, Peter M. Andersen, Martin Regensburger, Marie Dreger, Jan C. Koch, Julian Conrad, Thomas Meyer
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-5 (2024)
Abstract Background Since the antisense oligonucleotide tofersen has recently become available for the treatment of amyotrophic lateral sclerosis (ALS) caused by mutations in SOD1, determining the causality of the over 230 SOD1 variants has become ev
Externí odkaz:
https://doaj.org/article/6dd37b8edbb149059b7df64c953bc24a
Autor:
Maren Freigang, Petra Steinacker, Claudia D. Wurster, Olivia Schreiber‐Katz, Alma Osmanovic, Susanne Petri, Jan C. Koch, Kevin Rostásy, André Huss, Hayrettin Tumani, Benedikt Winter, Björn Falkenburger, Albert C. Ludolph, Markus Otto, Andreas Hermann, René Günther
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 9, Pp 1437-1448 (2022)
Abstract Objective Activated astroglia is involved in the pathophysiology of neurodegenerative diseases and has also been described in animal models of spinal muscular atrophy (SMA). Given the urgent need of biomarkers for treatment monitoring of new
Externí odkaz:
https://doaj.org/article/c8b8f412413243a2be7148386f821a08
Autor:
Maren Freigang, Claudia D. Wurster, Tim Hagenacker, Benjamin Stolte, Markus Weiler, Christoph Kamm, Olivia Schreiber‐Katz, Alma Osmanovic, Susanne Petri, Alexander Kowski, Thomas Meyer, Jan C. Koch, Isabell Cordts, Marcus Deschauer, Paul Lingor, Elisa Aust, Daniel Petzold, Albert C. Ludolph, Björn Falkenburger, Andreas Hermann, René Günther
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 5, Pp 1049-1063 (2021)
Abstract Objective To determine whether serum creatine kinase activity (CK) and serum creatinine concentration (Crn) are prognostic and predictive biomarkers for disease severity, disease progression, and nusinersen treatment effects in adult patient
Externí odkaz:
https://doaj.org/article/b45a627a87f940ddbcd346930af78a59
Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis
Autor:
Jan C. Koch, Josua Kuttler, Fabian Maass, Teresa Lengenfeld, Eirini Zielke, Mathias Bähr, Paul Lingor
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axona
Externí odkaz:
https://doaj.org/article/9965977abcc847f383c790d1dbd168fb
Autor:
Claudia D. Wurster, Jan C. Koch, Isabell Cordts, Jens Dreyhaupt, Markus Otto, Zeljko Uzelac, Simon Witzel, Benedikt Winter, Tugrul Kocak, Michael Schocke, Patrick Weydt, Kurt Wollinsky, Albert C. Ludolph, Marcus Deschauer, Paul Lingor, Hayrettin Tumani, Andreas Hermann, René Günther
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Background: Nusinersen is an antisense-oligonucleotide (ASO) approved for treatment of 5q-spinal muscular atrophy (SMA). Since the drug cannot cross the blood-brain barrier (BBB), it must be administered into the cerebrospinal fluid (CSF) space repea
Externí odkaz:
https://doaj.org/article/ea29c319a5254f108ea0190fc03ee2c7
Autor:
Claudia D. Wurster, René Günther, Petra Steinacker, Jens Dreyhaupt, Kurt Wollinsky, Zeljko Uzelac, Simon Witzel, Tugrul Kocak, Benedikt Winter, Jan C. Koch, Paul Lingor, Susanne Petri, Albert C. Ludolph, Andreas Hermann, Markus Otto
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Background: There is limited information on neurochemical markers being used to support and monitor the affection of motoneurons in patients with spinal muscular atrophy (SMA). The objective of this study was to examine neurochemical markers in cereb
Externí odkaz:
https://doaj.org/article/caae670915914644948f13b7a6cfe08d
Autor:
Paul Lingor, Markus Weber, William Camu, Tim Friede, Reinhard Hilgers, Andreas Leha, Christoph Neuwirth, René Günther, Michael Benatar, Magdalena Kuzma-Kozakiewicz, Helen Bidner, Christiane Blankenstein, Roberto Frontini, Albert Ludolph, Jan C. Koch, The ROCK-ALS Investigators, Shahram Attarian, Mathias Bähr, Matthias Boentert, Nathalie Braun, Philippe Corcia, Isabell Cordts, Marcus Deschauer, Thorsten Grehl, Julian Grosskreutz, Andreas Hermann, Josua Kuttler, Teresa Lengenfeldt, Fabian Maass, Thomas Meyer, Susanne Petri, Yvonne Remane, Jens Schmidt, Joachim Schuster, Marie-Hélène Soriani, Jeffrey Statland, Jochen Weishaupt, Daniel Zeller, Eirini Zielke
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Objectives: Disease-modifying therapies for amyotrophic lateral sclerosis (ALS) are still not satisfactory. The Rho kinase (ROCK) inhibitor fasudil has demonstrated beneficial effects in cell culture and animal models of ALS. For many years, fasudil
Externí odkaz:
https://doaj.org/article/c2fd5ccc946d44e2a5429cef5a1d3b8a
Autor:
Tim Ripperger, Winfried Hofmann, Jan C. Koch, Katayoon Shirneshan, Detlef Haase, Gerald Wulf, Peter R. Issing, Matthias Karnebogen, Gunnar Schmidt, Bernd Auber, Brigitte Schlegelberger, Thomas Illig, Birgit Zirn, Doris Steinemann
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Externí odkaz:
https://doaj.org/article/af110bbbb64a47e1928006932ade6439
Autor:
Kim-Ann Saal, Jan C. Koch, Lars Tatenhorst, Éva M. Szegő, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingor
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 150-162 (2015)
Parkinson's disease (PD) is a neurodegenerative disorder with prominent neuronal cell death in the substantia nigra (SN) and other parts of the brain. Previous studies in models of traumatic and neurodegenerative CNS disease showed that pharmacologic
Externí odkaz:
https://doaj.org/article/c2113aec27f04b79a88c4f5f1bf73ef8
Autor:
Jan C. Koch, Gonzalo P. Solis, Vsevolod Bodrikov, Uwe Michel, Deana Haralampieva, Aleksandra Shypitsyna, Lars Tönges, Mathias Bähr, Paul Lingor, Claudia A.O. Stuermer
Publikováno v:
Neurobiology of Disease, Vol 51, Iss , Pp 168-176 (2013)
The ability of fish retinal ganglion cells (RGCs) to regenerate their axons was shown to require the re-expression and function of the two proteins reggie-1 and -2. RGCs in mammals fail to upregulate reggie expression and to regenerate axons after le
Externí odkaz:
https://doaj.org/article/9b560f0fd8934e46ba13e8ebb4ada707