Spinal autofluorescent flavoprotein imaging in a rat model of nerve injury-induced pain and the effect of spinal cord stimulation.

Autor: Joost L M Jongen, Helwin Smits, Tiziana Pederzani, Malik Bechakra, Mehdi Hossaini, Sebastiaan K Koekkoek, Frank J P M Huygen, Chris I De Zeeuw, Jan C Holstege, Elbert A J Joosten

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109029 (2014)

Nerve injury may cause neuropathic pain, which involves hyperexcitability of spinal dorsal horn neurons. The mechanisms of action of spinal cord stimulation (SCS), an established treatment for intractable neuropathic pain, are only partially understo

Externí odkaz: https://doaj.org/article/8759699e8e824cfd9fb403c30dc1bf57

Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression in Mice Causes Mitochondrial Vacuolization, Axonal Degeneration, and Premature Motoneuron Death and Accelerates Motoneuron Disease in Mice Expressing a Familial Amyotrophic Lateral Sclerosis Mutant SOD1

Autor: Dick Jaarsma, Elize D. Haasdijk, J.A.C. Grashorn, Richard Hawkins, Wim van Duijn, Hein W. Verspaget, Jacqueline London, Jan C. Holstege

Publikováno v: Neurobiology of Disease, Vol 7, Iss 6, Pp 623-643 (2000)

Cytosolic Cu/Zn superoxide dismutase (SOD1) is a ubiquitous small cytosolic metalloenzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide (H2O2). Mutations in the SOD1 gene cause a familial form of amyotrophic lateral sclerosis

Externí odkaz: https://doaj.org/article/db05d241e2cf4ff69c6dc01d193fb531

Nerve reinnervation and itch behavior in a rat burn wound model

Autor: Tiam M. Saffari, Barthold N. Schüttenhelm, Jan C. Holstege, Johan W. van Neck

Publikováno v: Wound Repair and Regeneration, 26(1), 16-26. Wiley-Blackwell Publishing Ltd

In this study, we investigated whether postburn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as second/hour) at 24 hours,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfad21e778bc29a2a4c1582359fd9a4
https://pure.eur.nl/en/publications/44f8fc53-0549-4716-8e22-a9bb6a1b449b

Differential Changes in the Peptidergic and the Non-Peptidergic Skin Innervation in Rat Models for Inflammation, Dry Skin Itch, and Dermatitis

Autor: Jan C. Holstege, Erik T Walbeehm, Liron S. Duraku, Barthold N. Schüttenhelm, Jouke Dijkstra

Publikováno v: Journal of Investigative Dermatology, 135, 2049-57
Journal of Investigative Dermatology, 135, 8, pp. 2049-57
Journal of Investigative Dermatology, 135(8), 2049-2057. Nature Publishing Group

Item does not contain fulltext Skin innervation is a dynamic process that may lead to changes in nerve fiber density during pathological conditions. We have investigated changes in epidermal nerve fiber density in three different rat models that sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96855c4d85092acb8117ca12e2e5b129
https://doi.org/10.1038/jid.2015.137

Propagation of Spinal Nociceptive Activity in the Spatial and Temporal Domains

Autor: Jan C. Holstege, Joost L M Jongen

Publikováno v: Neuroscientist, 18(1), 8-14. SAGE Publishing

Nociceptive stimuli are transmitted through thinly myelinated or unmyelinated primary afferent fibers called nociceptors, which terminate mainly in the superficial dorsal horn of the spinal cord. While most nociceptive fibers terminate in the spinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f740d151cf10a506fb6c3de1b2830d1
https://doi.org/10.1177/1073858410391813