Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Jan Brábek"'
Autor:
Manfred Schreiber, Tomáš Macháček, Vojtěch Vajs, Barbora Šmídová, Martin Majer, Jiří Hrdý, Ondřej Tolde, Jan Brábek, Daniel Rösel, Petr Horák
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the intraperitoneal application
Externí odkaz:
https://doaj.org/article/c0cd1e571005414dafc8ba25864b2198
Autor:
Lenka Koudelková, Markéta Pelantová, Zuzana Brůhová, Martin Sztacho, Vojtěch Pavlík, Dalibor Pánek, Jakub Gemperle, Pavel Talacko, Jan Brábek, Daniel Rösel
Publikováno v:
eLife, Vol 12 (2023)
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state. The tr
Externí odkaz:
https://doaj.org/article/3b1c7c87d3bb4e7db96521db2ea11862
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The ability of cells to switch between different invasive modes during metastasis, also known as invasion plasticity, is an important characteristic of tumor cells that makes them able to resist treatment targeted to a particular invasion mode. Due t
Externí odkaz:
https://doaj.org/article/2e70a053724a4480b7de8718a16840de
Autor:
Jindriska Leischner Fialova, Katerina Hönigova, Martina Raudenska, Lucie Miksatkova, Renata Zobalova, Jiri Navratil, Jana Šmigová, Taraka Ramji Moturu, Tomas Vicar, Jan Balvan, Katerina Vesela, Nikita Abramenko, Zdenek Kejik, Robert Kaplanek, Jaromir Gumulec, Daniel Rosel, Pavel Martasek, Jan Brábek, Milan Jakubek, Jiri Neuzil, Michal Masarik
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 154, Iss , Pp 113582- (2022)
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together with the emerging idea of mitochondria as a pr
Externí odkaz:
https://doaj.org/article/80b69231f27345709bd67e8a884e9d4a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5068 (2023)
MT1-MMP (MMP-14) is a multifunctional protease that regulates ECM degradation, activation of other proteases, and a variety of cellular processes, including migration and viability in physiological and pathological contexts. Both the localization and
Externí odkaz:
https://doaj.org/article/e14354760cc34f8695393fc2b651ed81
Autor:
Magdalena Rašková, Lukáš Lacina, Zdeněk Kejík, Anna Venhauerová, Markéta Skaličková, Michal Kolář, Milan Jakubek, Daniel Rosel, Karel Smetana, Jan Brábek
Publikováno v:
Cells, Vol 11, Iss 22, p 3698 (2022)
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunit
Externí odkaz:
https://doaj.org/article/d08376423f0544388824b7da040f3086
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 264-289 (2019)
Protein p130Cas constitutes an adaptor protein mainly involved in integrin signaling downstream of Src kinase. Owing to its modular structure, p130Cas acts as a general regulator of cancer cell growth and invasiveness induced by different oncogenes.
Externí odkaz:
https://doaj.org/article/a8150fc97bc04d568eba1811cd1a86f5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 964 (2022)
Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affe
Externí odkaz:
https://doaj.org/article/b84f20172f5847319cd1b25fdaf2eeaa
Autor:
Joanna Patrycja Wróblewska, Michał Stefan Lach, Katarzyna Kulcenty, Łukasz Galus, Wiktoria Maria Suchorska, Daniel Rösel, Jan Brábek, Andrzej Marszałek
Publikováno v:
Cancers, Vol 13, Iss 13, p 3334 (2021)
Background: Uveal melanoma (UM) is the most common intraocular tumour in adults with a poor prognosis and extremely high mortality rate due to the development of metastatic disease. However, despite relatively good knowledge about the histological an
Externí odkaz:
https://doaj.org/article/82c23d250695433a98826f1712811141
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7805 (2021)
Cancer cell invasion through tissue barriers is the intrinsic feature of metastasis, the most life-threatening aspect of cancer. Detailed observation and analysis of cancer cell behaviour in a 3D environment is essential for a full understanding of t
Externí odkaz:
https://doaj.org/article/bf0dbe3fcede495583f9f70b6b1ce979