The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies

Autor: Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Fiona Sailler, Hannah Klute, Frederic Halgand, Guillaume Van der Rest, Yves Boulard, Vincent Béringue, Angelique Igel, Human Rezaei

It is commonly accepted that the prion replicative propensity and strain structural determinant (SSD) are encoded in the fold of PrPScamyloid fibril assemblies. By exploring the quaternary structure dynamicity of several prion strains, we revealed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40ea486405c97326afff9ec424c27738
https://doi.org/10.1101/2023.03.21.533631

Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

Autor: Margarida Pacheco, Ivo M. Aroso, Joana M. Silva, Sviatlana V. Lamaka, Jan Bohlen, Maria Nienaber, Dietmar Letzig, Estêvão Lima, Alexandre A. Barros, Rui L. Reis

Publikováno v: Journal of Magnesium and Alloys, Vol 11, Iss 11, Pp 4301-4324 (2023)

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged

Externí odkaz: https://doaj.org/article/183b40dbeefc4937a016821ae3089260

Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway

Autor: Vincent Béringue, Laetitia Herzog, Fabienne Reine, Jan Bohl, Christelle Jas-Duval, Mohammed Moudjou, Mathieu Mezache, Tina Knäpple, Florent Laferrière, Marie Doumic, Human Rezaei, Angélique Igel-Egalon

Publikováno v: Communications Biology
Communications Biology, Nature Publishing Group, 2019, 2, ⟨10.1038/s42003-019-0608-y⟩
Communications Biology, Nature Publishing Group, 2019, 2 (1), pp.1-13. ⟨10.1038/s42003-019-0608-y⟩
Communications Biology, Nature Publishing Group, 2019, 2 (1), ⟨10.1038/s42003-019-0608-y⟩
Communications Biology, 2019, 2 (1), pp.1-13. ⟨10.1038/s42003-019-0608-y⟩
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology (2), 1-13. (2019)

The dynamics of aggregation and structural diversification of misfolded, host-encoded proteins in neurodegenerative diseases are poorly understood. In many of these disorders, including Alzheimer’s, Parkinson’s and prion diseases, the misfolded p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7e971a289e198b553cd7689b31c66d
https://hal.archives-ouvertes.fr/hal-03401986/document

Influence of recycled carbon fiber addition on the microstructure and creep response of extruded AZ91 magnesium alloy

Autor: Sinan Kandemir, Jan Bohlen, Hajo Dieringa

Publikováno v: Journal of Magnesium and Alloys, Vol 11, Iss 7, Pp 2518-2529 (2023)

In this study, the recycled short carbon fiber (CF)-reinforced magnesium matrix composites were fabricated using a combination of stir casting and hot extrusion. The objective was to investigate the impact of CF content (2.5 and 5.0 wt.%) and fiber l

Externí odkaz: https://doaj.org/article/9d28270d2b154d40b86e35977e56a3b9

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

Autor: Luis P. B. Guerzoni, Jan Bohl, Alexander J. C. Kuehne, Laura De Laporte, Alexander Jans, Jonas C. Rose, Jens Koehler

Publikováno v: Biomaterials Science

Microfluidic encapsulation platforms have great potential not only in pharmaceutical applications but also in the consumer products industry. Droplet-based microfluidics is increasingly used for the production of monodisperse polymer microcapsules fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86b7e7e7043cd7a0c8e68a71ad2473