The prognostic impact of preoperative body composition in perihilar and intrahepatic cholangiocarcinoma

Autor: Isabella Lurje, Zoltan Czigany, Sarah Eischet, Jan Bednarsch, Tom Florian Ulmer, Peter Isfort, Pavel Strnad, Christian Trautwein, Frank Tacke, Ulf Peter Neumann, Georg Lurje

Publikováno v: Hepatology Communications, Vol 6, Iss 9, Pp 2400-2417 (2022)

Abstract Cholangiocarcinoma (CCA) is a rare but highly aggressive malignancy of the biliary system. Although it is amenable to surgical resection in early disease, outcomes are frequently dismal. Here, we investigated the prevalence of body compositi

Externí odkaz: https://doaj.org/article/85eb50205e174d9d96ccc921c571cc6c

ALPPS versus two-stage hepatectomy for colorectal liver metastases—–a comparative retrospective cohort study

Autor: Jan Bednarsch, Zoltan Czigany, Samara Sharmeen, Gregory van der Kroft, Pavel Strnad, Tom Florian Ulmer, Peter Isfort, Philipp Bruners, Georg Lurje, Ulf Peter Neumann

Publikováno v: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-13 (2020)

Abstract Background Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and two stage hepatectomy with inter-stage portal vein embolization (TSH/PVE) are surgical maneuvers applied in patients with advanced malignancie

Externí odkaz: https://doaj.org/article/9084a80ed87145adb633235e66b2ae15

The Role of Macrophage Polarization-Associated Gene Expression in the Oncological Prognosis of Hepatocellular Carcinoma

Autor: Dong Liu, Yankun Li, Guanwu Wang, Edgar Dahl, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch

Publikováno v: Gastroenterology Insights, Vol 15, Iss 3, Pp 764-785 (2024)

Background: The induced repolarization of tumor growth-promoting M2 macrophages into tumor growth-inhibiting M1 macrophages is a matter of intensive research and is expected to lead towards a novel targetable approach in HCC therapy. Methods: Differe

Externí odkaz: https://doaj.org/article/76d77d6e0376414e835e5f58726358ea

Preoperative predictors for non-resectability in perihilar cholangiocarcinoma

Autor: Carlos Constantin Otto, Anna Mantas, Lara Rosaline Heij, Daniel Heise, Maxime Dewulf, Sven Arke Lang, Tom Florian Ulmer, Edgar Dahl, Philipp Bruners, Ulf Peter Neumann, Jan Bednarsch

Publikováno v: World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Introduction Explorative laparotomy without subsequent curative-intent liver resection remains a major clinical problem in the treatment of perihilar cholangiocarcinoma (pCCA). Thus, we aimed to identify preoperative risk factors for non-res

Externí odkaz: https://doaj.org/article/30fd9a1d8b7e428abab87df63c79e7ff

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Autor: Julien Calderaro, Narmin Ghaffari Laleh, Qinghe Zeng, Pascale Maille, Loetitia Favre, Anaïs Pujals, Christophe Klein, Céline Bazille, Lara R. Heij, Arnaud Uguen, Tom Luedde, Luca Di Tommaso, Aurélie Beaufrère, Augustin Chatain, Delphine Gastineau, Cong Trung Nguyen, Hiep Nguyen-Canh, Khuyen Nguyen Thi, Viviane Gnemmi, Rondell P. Graham, Frédéric Charlotte, Dominique Wendum, Mukul Vij, Daniela S. Allende, Federico Aucejo, Alba Diaz, Benjamin Rivière, Astrid Herrero, Katja Evert, Diego Francesco Calvisi, Jérémy Augustin, Wei Qiang Leow, Howard Ho Wai Leung, Emmanuel Boleslawski, Mohamed Rela, Arnaud François, Anthony Wing-Hung Cha, Alejandro Forner, Maria Reig, Manon Allaire, Olivier Scatton, Denis Chatelain, Camille Boulagnon-Rombi, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Rüther, Sören A. Weidemann, Rami Rhaiem, Jean-Michel Pawlotsky, Xuchen Zhang, Alain Luciani, Sébastien Mulé, Alexis Laurent, Giuliana Amaddeo, Hélène Regnault, Eleonora De Martin, Christine Sempoux, Pooja Navale, Maria Westerhoff, Regina Cheuk-Lam Lo, Jan Bednarsch, Annette Gouw, Catherine Guettier, Marie Lequoy, Kenichi Harada, Pimsiri Sripongpun, Poowadon Wetwittayaklang, Nicolas Loménie, Jarukit Tantipisit, Apichat Kaewdech, Jeanne Shen, Valérie Paradis, Stefano Caruso, Jakob Nikolas Kather

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal

Externí odkaz: https://doaj.org/article/ba65186be9624b389ea48c3c89596cfd