Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jan Bart M. Koorstra"'
Autor:
William Matsui, David M. Berman, Christine A. Iacobuzio-Donahue, N. V. Rajeshkumar, Michael Goggins, Daniel A. Laheru, Zeshaan A. Rasheed, Anirban Maitra, Christopher Murter, Jan Bart M. Koorstra, Jeanne Kowalski, Irwin Freed, Jie Yang, Manuel Hidalgo, Antonio Jimeno, Qiuju Wang, Seung-Mo Hong, Xiaobing He
Publikováno v:
JNCI: Journal of the National Cancer Institute. 102:340-351
Background Specific populations of highly tumorigenic cells are thought to exist in many human tumors, including pancreatic adenocarcinoma. However, the clinical significance of these tumor-initiating (ie, cancer stem) cells remains unclear. Aldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53756c7710fd2517bf402628b85ab17d
https://doi.org/10.1093/jnci/djp535
https://doi.org/10.1093/jnci/djp535
Autor:
Chanjuan Shi, Alan K. Meeker, Michael Goggins, Jan Bart M. Koorstra, Anirban Maitra, Ralph H. Hruban, Seung-Mo Hong, Ji Kon Ryu, G. J. A. Offerhaus
Publikováno v:
Modern Pathology, 22(11), 1439-1445. Nature Publishing Group
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Pancreatic intraepithelial neoplasia (PanIN) lesions are the most common non-invasive precursors of pancreatic adenocarcinoma. We postulated that accumulating DNA damage within the PanIN epithelium activates checkpoint mechanisms. Tissue microarrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9ac787e347b660d10654c179d14f0e
https://doi.org/10.1038/modpathol.2009.114
https://doi.org/10.1038/modpathol.2009.114
Autor:
Pamela Leal Rojas, G. Johan A. Offerhaus, Anirban Maitra, Collins Karikari, Georg Feldmann, Jan Bart M. Koorstra, Savita Bisht, Hector A Alvarez
Publikováno v:
Cancer biology & therapy, 8(7), 618-626. Landes Bioscience
Cancer biology & therapy, 8(7), 618-626. Taylor & Francis Group
Cancer biology & therapy, 8(7), 618-626. Taylor & Francis Group
BACKGROUND: Pancreatic cancer is a near uniformly lethal disease and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics. The Axl receptor tyrosine kinase is implicated in cellular transformation and tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec72853eb0b31fdbedd9155ff82ed19
https://doi.org/10.4161/cbt.8.7.7923
https://doi.org/10.4161/cbt.8.7.7923
Publikováno v:
Pancreatology. 8:110-125
Pancreatic cancer is an almost universally lethal disease. Research over the last two decades has shown that pancreatic cancer is fundamentally a genetic disease, caused by inherited germline and acquired somatic mutations in cancer-associated genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe840e90b526a29dcc4958ba9b191bd
https://doi.org/10.1159/000123838
https://doi.org/10.1159/000123838
Publikováno v:
Langenbeck's Archives of Surgery. 393:561-570
Pancreatic ductal adenocarcinoma (i.e., pancreatic cancer) is an almost universally lethal disease. The identification of precursor lesions of pancreatic cancer provides an opportunity for early detection and potential therapeutic intervention before
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6518c960b4d174b3b423a08e651277d
https://doi.org/10.1007/s00423-008-0282-x
https://doi.org/10.1007/s00423-008-0282-x
Autor:
Stephanie Duringer, Georg Feldmann, Volker Fendrich, Petra Volkmann, Peter Brossart, Collins Karikari, Marco Dal Molin, Anirban Maitra, Detlef K. Bartsch, Savita Bisht, Jan Bart M. Koorstra
Publikováno v:
Cancer biologytherapy. 11(11)
An inactivating germline mutation in BRCA2 is the most common known genetic basis for familial pancreatic cancer (FPC), accounting for 5-10% of inherited cases. A genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) arising o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cfb3f7a8f8423af07ee8a859a88cc5
https://pubmed.ncbi.nlm.nih.gov/21610317
https://pubmed.ncbi.nlm.nih.gov/21610317
Autor:
Xing Fan, William Matsui, Georg Feldmann, Yue Ming Li, Anirban Maitra, Charles G. Eberhart, Jan Bart M. Koorstra, G. Johan A. Offerhaus, Clark M. Henderson, Michael Mullendore
Publikováno v:
Clinical cancer research, 15(7), 2291-2301. American Association for Cancer Research Inc.
Purpose: Aberrant activation of the Notch signaling pathway is commonly observed in human pancreatic cancer, although the mechanism(s) for this activation has not been elucidated. Experimental Design: A panel of 20 human pancreatic cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb139c4d295fa974ae06d57146d7af5
https://pure.amc.nl/en/publications/liganddependent-notch-signaling-is-involved-in-tumor-initiation-and-tumor-maintenance-in-pancreatic-cancer(3ffa5278-c30d-4b40-a80f-d7d8b4eb18f5).html
https://pure.amc.nl/en/publications/liganddependent-notch-signaling-is-involved-in-tumor-initiation-and-tumor-maintenance-in-pancreatic-cancer(3ffa5278-c30d-4b40-a80f-d7d8b4eb18f5).html
Autor:
Anirban Maitra, Savita Bisht, Amarnath Maitra, Collins Karikari, Georg Feldmann, Carlton K. K. Lee, Hector A Alvarez, Michael Mullendore, Michelle A. Rudek, Jan Bart M. Koorstra
Publikováno v:
Molecular cancer therapeutics. 7(12)
Nanotechnology has enabled significant advances in the areas of cancer diagnosis and therapy. The field of drug delivery is a sterling example, with nanoparticles being increasingly used for generating therapeutic formulations of poorly water-soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49887485c2e888573cdf72ba70095aa
https://pubmed.ncbi.nlm.nih.gov/19074860
https://pubmed.ncbi.nlm.nih.gov/19074860
Autor:
Folkert H.M. Morsink, Fiebo J.W. ten Kate, Jan Bart M. Koorstra, Johan Offerhaus, Ralph H. Hruban, Paul Drillenburg, Anirban Maitra
Publikováno v:
American journal of surgical pathology, 32(12), 1905-1909. Lippincott Williams and Wilkins
The p16 gene on chromosome 9p is a tumor suppressor that inhibits the cell cycle by binding Cdk4 and Cdk6 and interfering with their ability to phosporylate RB1.6,7 More than 90% of the sporadic pancreatic adenocarcinomas show complete loss of functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a701aea022c0d5b8f0d80aacdf66e15f
https://pubmed.ncbi.nlm.nih.gov/18813118
https://pubmed.ncbi.nlm.nih.gov/18813118
Autor:
Djahida Bedja, Jan Bart M. Koorstra, Nils Habbe, Michael Mullendore, Volker Fendrich, Collins Karikari, Savita Bisht, Georg Feldmann, Karen McGovern, Rajni Sharma, Kathleen L. Gabrielson, Hector A Alvarez, Anirban Maitra, William Matsui
Publikováno v:
Molecular cancer therapeutics. 7(9)
Recent evidence suggests that blockade of aberrant Hedgehog signaling can be exploited as a therapeutic strategy for pancreatic cancer. Our previous studies using the prototype Hedgehog small-molecule antagonist cyclopamine had shown the striking inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4368725a586341f8f863bf23424c7cbb
https://pubmed.ncbi.nlm.nih.gov/18790753
https://pubmed.ncbi.nlm.nih.gov/18790753