Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Jan B. Parys"'
Autor:
Elżbieta Kania, Jaclyn S. Long, David G. McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Kevin M. Ryan, Jan B. Parys
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance also for Crohn’s disease and cancer. LRRK2 is a large and complex protein possessing both G
Externí odkaz:
https://doaj.org/article/ac990b44ebe440e7985118a7bf10125c
Publikováno v:
Cells, Vol 12, Iss 21, p 2527 (2023)
Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP3R interaction, we developed and characterize
Externí odkaz:
https://doaj.org/article/27ab4587af484dc7a6da653475295f8a
Autor:
Valerio Farfariello, Dmitri V. Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loïc Lemonnier, Natalia Prevarskaya
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Mitochondrial Ca2+ homeostasis is reported to influence cellular senescence. Here the authors show that TRPC3 limits senescence by inhibiting IP3R-mediated Ca2+ release and ER mitochondria Ca2+ transfer and that the downregulation of TRPC3 in stromal
Externí odkaz:
https://doaj.org/article/18e1a197a54f4fbebb56df91fdd44151
Autor:
Jan B. Parys, Fabien Van Coppenolle
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import in the ER during translat
Externí odkaz:
https://doaj.org/article/4013b49faced4d85be8adfdd8a2b301e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9777 (2020)
The store-operated calcium entry, better known as SOCE, forms the main Ca2+ influx pathway in non-excitable cells, especially in leukocytes, where it is required for cell activation and the immune response. During the past decades, several inhibitors
Externí odkaz:
https://doaj.org/article/a858a2f39ebb499d9d9e481c7fcaf014
Autor:
Carlos Pascual-Caro, Yolanda Orantos-Aguilera, Irene Sanchez-Lopez, Jaime de Juan-Sanz, Jan B. Parys, Estela Area-Gomez, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6598 (2020)
STIM1 is an endoplasmic reticulum (ER) protein that modulates the activity of a number of Ca2+ transport systems. By direct physical interaction with ORAI1, a plasma membrane Ca2+ channel, STIM1 activates the ICRAC current, whereas the binding with t
Externí odkaz:
https://doaj.org/article/d041ae628ab2469bbc4b4dc6dc194a03
Autor:
Bruno Seitaj, Felicia Maull, Li Zhang, Verena Wüllner, Christina Wolf, Philipp Schippers, Rita La Rovere, Ute Distler, Stefan Tenzer, Jan B. Parys, Geert Bultynck, Axel Methner
Publikováno v:
Cells, Vol 9, Iss 10, p 2147 (2020)
The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and has been implicated in cell death susceptibility. The only member with a mitochondrial localization is TMBIM5 (also known as GHITM or MICS1), wh
Externí odkaz:
https://doaj.org/article/83025d6a4797438f829a65f8d382a769
Autor:
Jenny Sprooten, Pieter De Wijngaert, Isaure Vanmeerbeek, Shaun Martin, Peter Vangheluwe, Susan Schlenner, Dmitri V. Krysko, Jan B. Parys, Geert Bultynck, Peter Vandenabeele, Abhishek D. Garg
Publikováno v:
Cells, Vol 9, Iss 8, p 1823 (2020)
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain unresponsive to ICBs due to widespread immuno-resistance. To “break
Externí odkaz:
https://doaj.org/article/3c46b3c6e3b34df9987c4428e0f4bcfe
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Calcium ions (Ca2+) play a complex role in orchestrating diverse cellular processes, including cell death and survival. To trigger signaling cascades, intracellular Ca2+ is shuffled between the cytoplasm and the major Ca2+ stores, the endoplasmic ret
Externí odkaz:
https://doaj.org/article/b3cbeb67757e4bff8c51a1ce0279eb94
Publikováno v:
Cells, Vol 1, Iss 3, Pp 284-312 (2012)
Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and
Externí odkaz:
https://doaj.org/article/c5aefd9c353b48d3ae1436823f06d8ae