Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Jan B F Hulscher"'
Autor:
Christian V Hulzebos, Anne G J F van Zoonen, Jan B F Hulscher, Trijntje E Schat, Elisabeth M W Kooi, Martijn Koehorst, Renze Boverhof, Paul F M Krabbe, Albert K Groen, Henkjan J Verkade
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168633 (2017)
Intestinal bile salts (BSs) may be implicated in NEC development. We hypothesized that fecal BS levels are higher in preterm infants at risk for NEC.We compared the composition and concentration of fecal BSs in ten preterm infants who developed NEC (
Externí odkaz:
https://doaj.org/article/aba2e62fd24e4b9da88fb9f71bd375c8
Autor:
Trijntje E Schat, Maarten Schurink, Michelle E van der Laan, Jan B F Hulscher, Christian V Hulzebos, Arend F Bos, Elisabeth M W Kooi
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154710 (2016)
OBJECTIVES:To investigate whether cerebral, liver, and infraumbilical regional tissue oxygen saturation (rSO2) and fractional tissue oxygen extraction (FTOE) could be used to diagnose necrotizing enterocolitis (NEC) and complicated NEC (Bell's stage
Externí odkaz:
https://doaj.org/article/be4e258680d24b36b4df61d92695d885
Autor:
Maarten Schurink, Elisabeth M W Kooi, Christian V Hulzebos, Rozemarijn G Kox, Henk Groen, Erik Heineman, Arend F Bos, Jan B F Hulscher
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121336 (2015)
Early NEC symptoms are non-specific and diagnostic tests lack discriminative power. Intestinal fatty acid-binding protein (I-FABP), mainly located in small bowel enterocytes, is released into the blood following NEC-associated enterocyte disruption.
Externí odkaz:
https://doaj.org/article/5fc10463d5b344eeba25a4604b147c17
Autor:
Raquel Dos Santos Martins, Jan B. F. Hulscher, Albert Timmer, Elisabeth M. W. Kooi, Klaas Poelstra
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionNecrotizing enterocolitis (NEC) is a life-threatening inflammatory disease. Its onset might be triggered by Toll-Like Receptor 4 (TLR4) activation via bacterial lipopolysaccharide (LPS). We hypothesize that a deficiency of intestinal alka
Externí odkaz:
https://doaj.org/article/b071803383f8418d8e7846566a81e56c
Autor:
Rosa Verhoeven, Jan B. F. Hulscher
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/3744dcf72cd64f58af3a8d040243f954
Autor:
Daphne H. Klerk, Otis C. van Varsseveld, Martin Offringa, Neena Modi, Martin Lacher, Augusto Zani, Mikko P. Pakarinen, Antti Koivusalo, Ingo Jester, Marie Spruce, Joep P. M. Derikx, Roel Bakx, Amine Ksia, Marijn J. Vermeulen, Elisabeth M. W. Kooi, Jan B. F. Hulscher
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Aim Necrotizing enterocolitis (NEC) is the most lethal disease of the gastrointestinal tract of preterm infants. New and existing management strategies need clinical evaluation. Large heterogeneity exists in the selection, measurement, and r
Externí odkaz:
https://doaj.org/article/dbd5b570f52d4e31962c3849dcd6c9f6
Human precision-cut cystic duct and gallbladder slices: a novel method for studying cholangiopathies
Autor:
Jeske Fridrichs, Bart Hamel, Wendy Kelder, Ewoud van den Hoed, Marius C. van den Heuvel, Jan B. F. Hulscher, Peter Olinga
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Background and aimsPrecision-cut tissue slices (PCTS) are widely used as an ex vivo culture tissue culture technique to study pathogeneses of diseases and drug activities in organs in vitro. A novel application of the PCTS model may be in the field o
Externí odkaz:
https://doaj.org/article/34ad282979d94046bbf1cd2d1f717ab6
Autor:
Otis C. van Varsseveld, Annebel ten Broeke, Caspar G. Chorus, Nicolaas Heyning, Elisabeth M. W. Kooi, Jan B. F. Hulscher
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundCritical decision making in surgical necrotizing enterocolitis (NEC) is highly complex and hard to capture in decision rules due to case-specificity and high mortality risk. In this choice experiment, we aimed to identify the implicit weigh
Externí odkaz:
https://doaj.org/article/47dc8cc460a743cd85e763b39014d217
Autor:
Daphne H. Klerk, Lisanne K. van Avezaath, Erik A. H. Loeffen, Jan B. F. Hulscher, Elisabeth M. W. Kooi
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2023)
BackgroundFetal and neonatal exposure to antibiotics may contribute to the development of necrotizing enterocolitis (NEC) in preterm infants. This systematic review and meta-analysis investigate whether exposure to third trimester maternal antibiotic
Externí odkaz:
https://doaj.org/article/1670f7bcde46450480c047674b1f4ef9
Autor:
Mark Nomden, Naved K. Alizai, Pietro Betalli, Janneke L. M. Bruggink, Mara Cananzi, Vibeke Brix Christensen, Lorenzo D’Antiga, Mark Davenport, Björn Fischler, Luise Hindemith, Maria Hukkinen, Lars S. Johansen, Ruben H. de Kleine, Omid Madadi-Sanjani, Evelyn G. P. Ong, Mikko P. Pakarinen, Claus Petersen, Mathias Ruiz, Matthias Schunn, Ekkehard Sturm, Henkjan J. Verkade, Barbara E. Wildhaber, Jan B. F. Hulscher, on behalf of members of the Biliary Atresia and Related Disorders (BARD) Community & the ERN RA-RE-LIVER
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 3, p 775 (2023)
Background: Biliary atresia (BA) is a rare cholangiopathy where one of the proposed aetiological mechanisms is an infectious viral trigger. Coronavirus disease-19 (COVID) lockdown restrictions were implemented to reduce the transmission of infections
Externí odkaz:
https://doaj.org/article/11c4aff256794ae69531d75466072c54