Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jan B Egan"'
Autor:
Gavin R Oliver, Sofia Marcano-Bonilla, Jonathan Quist, Ezequiel J Tolosa, Eriko Iguchi, Amy A Swanson, Nicole L Hoppman, Tanya Schwab, Ashley Sigafoos, Naresh Prodduturi, Jesse S Voss, Shannon M Knight, Jin Zhang, Numrah Fadra, Raul Urrutia, Michael Zimmerman, Jan B Egan, Anthony G Bilyeu, Jin Jen, Ema Veras, Rema'a Al-Safi, Matthew Block, Sarah Kerr, Martin E Fernandez-Zapico, John K Schoolmeester, Eric W Klee
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250518 (2021)
Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions arising from placental tissue. Epithelioid trophoblastic tumor (ETT), derived from chorionic-type trophoblast, is the rarest form of GTD with only approximately 130 cases des
Externí odkaz:
https://doaj.org/article/2bf13702df0b43e381666c65815dbd11
Autor:
Mitesh J Borad, Mia D Champion, Jan B Egan, Winnie S Liang, Rafael Fonseca, Alan H Bryce, Ann E McCullough, Michael T Barrett, Katherine Hunt, Maitray D Patel, Scott W Young, Joseph M Collins, Alvin C Silva, Rachel M Condjella, Matthew Block, Robert R McWilliams, Konstantinos N Lazaridis, Eric W Klee, Keith C Bible, Pamela Harris, Gavin R Oliver, Jaysheel D Bhavsar, Asha A Nair, Sumit Middha, Yan Asmann, Jean-Pierre Kocher, Kimberly Schahl, Benjamin R Kipp, Emily G Barr Fritcher, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Phillips, Jackie McDonald, Jonathan Adkins, Stephen D Mastrian, Pamela Placek, Aprill T Watanabe, Janine Lobello, Haiyong Han, Daniel Von Hoff, David W Craig, A Keith Stewart, John D Carpten
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004135 (2014)
Advanced cholangiocarcinoma continues to harbor a difficult prognosis and therapeutic options have been limited. During the course of a clinical trial of whole genomic sequencing seeking druggable targets, we examined six patients with advanced chola
Externí odkaz:
https://doaj.org/article/72d9a122f58441d9a86d9254c686cd3b
Autor:
Jan B Egan, Michael T Barrett, Mia D Champion, Sumit Middha, Elizabeth Lenkiewicz, Lisa Evers, Princy Francis, Jessica Schmidt, Chang-Xin Shi, Scott Van Wier, Sandra Badar, Gregory Ahmann, K Martin Kortuem, Nicole J Boczek, Rafael Fonseca, David W Craig, John D Carpten, Mitesh J Borad, A Keith Stewart
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87113 (2014)
Liposarcoma is the most common soft tissue sarcoma, but little is known about the genomic basis of this disease. Given the low cell content of this tumor type, we utilized flow cytometry to isolate the diploid normal and aneuploid tumor populations f
Externí odkaz:
https://doaj.org/article/c53ceb6aae97487dadd8f77b22d5f349
Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.
Autor:
Winnie S Liang, David W Craig, John Carpten, Mitesh J Borad, Michael J Demeure, Glen J Weiss, Tyler Izatt, Shripad Sinari, Alexis Christoforides, Jessica Aldrich, Ahmet Kurdoglu, Michael Barrett, Lori Phillips, Hollie Benson, Waibhav Tembe, Esteban Braggio, Jeffrey A Kiefer, Christophe Legendre, Richard Posner, Galen H Hostetter, Angela Baker, Jan B Egan, Haiyong Han, Douglas Lake, Edward C Stites, Ramesh K Ramanathan, Rafael Fonseca, A Keith Stewart, Daniel Von Hoff
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e43192 (2012)
Pancreatic adenocarcinoma (PAC) is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently available therapies prov
Externí odkaz:
https://doaj.org/article/8bbd106cd51d413ca0f1e24b592ba757
Autor:
Elizabeth T. Jacobs, David Mount, María Elena Martínez, Elizabeth C. LeRoy, Peter W. Jurutka, Elizabeth Hibler, David Duggan, David V. Conti, Erin L. Ashbeck, Patricia A. Thompson, Jan B. Egan
Supplementary Tables 1-2 from Genetic Polymorphisms in Vitamin D Receptor VDR/RXRA Influence the Likelihood of Colon Adenoma Recurrence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1d8d4687e9803bd1cc39617e20b16
https://doi.org/10.1158/0008-5472.22387433
https://doi.org/10.1158/0008-5472.22387433
Autor:
Karan K. Budhraja, Bradon R. McDonald, Michelle D. Stephens, Tania Contente-Cuomo, Havell Markus, Maria Farooq, Patricia F. Favaro, Sydney Connor, Sara A. Byron, Jan B. Egan, Brenda Ernst, Timothy K. McDaniel, Aleksandar Sekulic, Nhan L. Tran, Michael D. Prados, Mitesh J. Borad, Michael E. Berens, Barbara A. Pockaj, Patricia M. LoRusso, Alan Bryce, Jeffrey M. Trent, Muhammed Murtaza
Publikováno v:
Science Translational Medicine. 15
Genome-wide fragmentation patterns in cell-free DNA (cfDNA) in plasma are strongly influenced by cellular origin due to variation in chromatin accessibility across cell types. Such differences between healthy and cancer cells provide the opportunity
Autor:
Parminder Singh, Irbaz Bin Riaz, Cassandra N. Moore, Heidi E. Kosiorek, Renee K. Sharpsten, Andrea McNatty, Glenn A. Stewart, Steven R. Hwang, Alan H. Bryce, Thai H. Ho, Jan B. Egan, Miguel Gonzalez Velez, Brian A. Costello
Publikováno v:
Prostate Cancer and Prostatic Diseases. 25:479-483
Background Altered tumor suppressor genes (TSG-alt) in prostate cancer are associated with worse outcomes. The prognostic value of TSG-alt in metastatic, hormone-sensitive prostate cancer (M1-HSPC) is unknown. We evaluated the effects of TSG-alt on o
Autor:
Whitley Hatton, Beth Dellinger, Emmanuel S. Antonarakis, Jan B. Egan, Heather H. Cheng, Jodi Lyn Layton, Neal D. Shore, Oliver Sartor, Brian E. Lewis, Jason Zhu, Marcus Marie Moses, Mari Nakazawa, Elisa Ledet, Alexandra O. Sokolova, Patrick Cotogno, Earle F. Burgess, Nellie Nafissi, Pedro C. Barata, Alan H. Bryce, Ellen Jaeger, Rana R. McKay, Patrick J. Miller, Sara Elrefai
Publikováno v:
The Prostate
Background The goal of this study is to evaluate germline genetic variants in African American men with metastatic prostate cancer as compared to those in Caucasian men with metastatic prostate cancer in an effort to understand the role of genetic fa
Autor:
Aradhana Kasimsetty, Elzbieta Lenkiewicz, James M Bogenberger, Jan B. Egan, Bolni Marius Nagalo, Smriti Malasi, Mitesh J. Borad, Pedro L.S. Uson, Heidi E. Kosiorek, Jennifer L. Leiting, Marcela Salomao, Amro M. Abdelrahman, Mark J. Truty, Mansi Arora, Michael T. Barrett, Esteban Braggio, Yumei Zhou, Xianfeng Chen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 85:1063-1078
NUC1031 is a first-in-class ProTide, that is a gemcitabine pro-drug designed to overcome putative mechanisms of resistance, including decreased expression of hENT/hCNT transporters, absence of activating enzymes such as deoxycytidine kinase (dCK) and
Autor:
Amro M. Abdelrahman, Michael T. Barrett, Roberto Alva-Ruiz, Daniel H. Ahn, Nathalie Meurice, Yumei Zhou, Lewis R. Roberts, Scott I. Gamb, Heidi E. Kosiorek, Jennifer A. Yonkus, Eeva-Liisa Eskelinen, Chelsae Dumbauld, Mohamad Bassam Sonbol, Xianfeng Chen, Tanios Bekaii-Saab, James M Bogenberger, Esteban Braggio, Jennifer L. Leiting, Mark J. Truty, Marcela Salomao, Mitesh J. Borad, Bolni Marius Nagalo, Aaron S. Mansfield, Jan B. Egan, Alexander T. Baker, Pedro Luiz Serrano Uson Junior, Mansi Arora, Kenneth H. Buetow
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES. 75(1)
Biliary tract cancers (BTCs) are uncommon, but highly lethal, gastrointestinal malignancies. Gemcitabine/cisplatin is a standard-of-care systemic therapy, but has a modest impact on survival and harbors toxicities, including myelosuppression, nephrop