Zobrazeno 1 - 10 of 164 pro vyhledávání: '"Jan B, Koenderink"'
1
Akademický článek
The potential role of drug transporters and amikacin modifying enzymes in M. avium
Autor: Jodie A. Schildkraut, Jordy P.M. Coolen, Carolien Ruesen, Jeroen J.M.W. van den Heuvel, Laura Edo Aceña, Heiman F.L. Wertheim, Robert S. Jansen, Jan B. Koenderink, Lindsey H.M. te Brake, Jakko van Ingen
Publikováno v: Journal of Global Antimicrobial Resistance, Vol 34, Iss , Pp 161-165 (2023)
ABSTRACT: Objectives: Mycobacterium avium (M. avium) complex bacteria cause opportunistic infections in humans. Treatment yields cure rates of 60% and consists of a macrolide, a rifamycin, and ethambutol, and in severe cases, amikacin. Mechanisms of
Externí odkaz: https://doaj.org/article/428d96b8d247445583aa3ae8c8c94a1b
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2
Akademický článek
Transporter-Mediated Cellular Distribution of Tyrosine Kinase Inhibitors as a Potential Resistance Mechanism in Chronic Myeloid Leukemia
Autor: Noor E. Verhagen, Jan B. Koenderink, Nicole M. A. Blijlevens, Jeroen J. W. M. Janssen, Frans G. M. Russel
Publikováno v: Pharmaceutics, Vol 15, Iss 11, p 2535 (2023)
Chronic myeloid leukemia (CML) is a hematologic neoplasm characterized by the expression of the BCR::ABL1 oncoprotein, a constitutively active tyrosine kinase, resulting in uncontrolled growth and proliferation of cells in the myeloid lineage. Target
Externí odkaz: https://doaj.org/article/ecae994a797a441589e8232b857ff9c3
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4
Akademický článek
Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis
Autor: Carlijn H. C. Litjens, Laurens F. M. Verscheijden, Elin M. Svensson, Petra H. H. van den Broek, Hedwig van Hove, Jan B. Koenderink, Frans G. M. Russel, Rob E. Aarnoutse, Lindsey H. M. te Brake
Publikováno v: Antibiotics, Vol 12, Iss 4, p 702 (2023)
Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown. This study aimed to predict linezo
Externí odkaz: https://doaj.org/article/1cda5fe5ffa44c3da3aedc061453a16f
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5
Akademický článek
Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.
Autor: Laurens F M Verscheijden, Carlijn H C Litjens, Jan B Koenderink, Ron H J Mathijssen, Marcel M Verbeek, Saskia N de Wildt, Frans G M Russel
Publikováno v: PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)
Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability,
Externí odkaz: https://doaj.org/article/453e7f115c204fa085ec5f77bb94a806
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6
Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)
Autor: Jochem Louisse, Luca Dellafiora, Jeroen J. M. W. van den Heuvel, Deborah Rijkers, Liz Leenders, Jean-Lou C. M. Dorne, Ans Punt, Frans G. M. Russel, Jan B. Koenderink
Publikováno v: Archives of Toxicology, 97, 3, pp. 685-696
Archives of Toxicology 97 (2023) 3
Archives of Toxicology, 97(3), 685-696
Archives of Toxicology, 97, 685-696
Contains fulltext : 291310.pdf (Publisher’s version ) (Open Access) Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a27e391e6bed55ba30277471e5341f
https://hdl.handle.net/2066/291310
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7
Akademický článek
Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
Autor: Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink
Publikováno v: Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DD
Externí odkaz: https://doaj.org/article/b27f86145f49479db057cc1f0f96e3c4
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8
Akademický článek
Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.
Autor: Laurens F M Verscheijden, Jan B Koenderink, Saskia N de Wildt, Frans G M Russel
Publikováno v: PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)
Different pediatric physiologically-based pharmacokinetic (PBPK) models have been described incorporating developmental changes that influence plasma drug concentrations. Drug disposition into cerebrospinal fluid (CSF) is also subject to age-related
Externí odkaz: https://doaj.org/article/2821067b0bc043ab9c57c0e99109d14f
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10
Akademický článek
Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule
Autor: Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt
Publikováno v: Pharmaceutics, Vol 12, Iss 10, p 935 (2020)
Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat
Externí odkaz: https://doaj.org/article/044f751e0f7e4c77bcf1c387e2aa60ef
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