Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jan Amstrup"'
Autor:
Sibel Kalyoncu, Emily K. Makowski, Lotte T Spang, Peter M. Tessier, Wenjia Lou, Samuel D Stimple, Karen Duus, Jan Amstrup, Arne Staby, Alec A. Desai, Jesper E Mogensen, Désirée J Asgreen, Yulei Zhang
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(2)
Biologics such as peptides and proteins possess a number of attractive attributes that make them particularly valuable as therapeutics, including their high activity, high specificity, and low toxicity. However, one of the key challenges associated w
Publikováno v:
Biochimica et biophysica acta. 1858(9)
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 450:429-436
Extracellular ATP is an important regulator of transepithelial transport in a number of tissues. In pancreatic ducts, we have shown that ATP modulates epithelial K+ channels via purinergic receptors, most likely the P2Y2 and P2Y4 receptors, but the i
Publikováno v:
American Journal of Physiology-Renal Physiology. 286:F385-F393
The renal peptide transporter PEPT2 plays an important role in absorption of di- and tripetides in the proximal tubule; however, knowledge of regulation of PEPT2 by growth factors and hormones is limited. In the present study, we examined the effects
Autor:
Niels J. Willumsen, Åse Jespersen, Poul Kristensen, E. Hviid Larsen, Nadja Møbjerg, Jan Amstrup
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:2245-2246
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618(2):120-132
Krogh introduced the concept of active ion uptake across surface epithelia of freshwater animals, and proved independent transports of Na(+) and Cl(-) in anuran skin and fish gill. He suggested that the fluxes of Na(+) and Cl(-) involve exchanges wit
Autor:
Ivana Novak, Jan Amstrup
Publikováno v:
Biochemical Journal. 374:51-61
P2X7 nucleotide receptors modulate a spectrum of cellular events in various cells including epithelia, such as exocrine pancreas. Although the pharmacology and channel properties of the P2X7 receptors have been studied intensively, signal transductio
Autor:
Sven Frokjaer, Carsten Uhd Nielsen, Robert Nielsen, Birger Brodin, Jan Amstrup, Bente Steffansen
Publikováno v:
Acta Physiologica Scandinavica. 178:139-148
Aim: Little is known about the physiological regulation of the human intestinal di/tri-peptide transporter, hPepT1. In the present study we evaluated the effects of epidermal growth factor (EGF) and insulin on hPepT1-mediated dipeptide uptake in the
Publikováno v:
Drug Development Research. 59:128-135
ATP and other nucleotides are released from various cells, but the pathway and physiological stimulus for ATP release are often unclear. The focus of our studies is the understanding of ATP release and signaling in rat exocrine pancreas. In acinar su
Publikováno v:
Journal of Membrane Biology. 186:43-53
The Ca2+ content of pancreatic juice is closely regulated by yet unknown mechanisms. One aim of the present study was to find whether rat pancreatic ducts have a Na+/Ca2+ exchanger, as found in some Ca2+ transporting epithelia. Another aim was to est